Microvascular Complications of Diabetes Mellitus Flashcards
State the 3 main sites of microvascular complications.
Retinal arteries (retinopathy) Glomerular arterioles (nephropathy) Vasa vasorum (neuropathy)
What 4 factors correlate with risk of microvascular and macrovascular complications?
Glycaemic control (HbA1c)
Hypertension
Genetics
Glycaemic memory
Describe the mechanism of glucose damage to blood vessels.
Hyperglycaemia leads to oxidative stress + hypoxia
This triggers an inflammatory cascade, which leads to local activation of pro-inflammatory cytokines, inflammation + damage
What instrument is used to look into the eye?
Fundoscope
What are the 4 types of diabetic retinopathy?
Background
Pre-proliferative
Proliferative
Maculopathy
What three features do you see in background diabetic retinopathy?
Hard exudates
Microaneurysms
Blot haemorrhages
What are hard exudates caused by?
Leakage of lipid contents makes the back of the eye look a cheesy colour
Describe pre-proliferative diabetic retinopathy.
Soft exudates (cotton wool spots) There will be some haemorrhages
What do soft exudates indicate?
Retinal ischaemia
Describe proliferative diabetic retinopathy.
Involves the formation of new vessels (in response to retinal ischaemia)
New vessels are generally more fragile + can bleed at any time
Describe maculopathy.
Hard exudates near the macula
Same disease as background diabetic retinopathy, but hard exudates are near macula
This can threaten direct vision
What are the steps taken in managing background diabetic retinopathy?
Improve blood glucose control
What is the treatment for pre-proliferative and proliferative diabetic retinopathy?
Pan-retinal photocoagulation
Describe the treatment of maculopathy.
Need a grid of photocoagulation in the affected area (aim to limit damage to the macula (so NOT pan-retinal photo coagulation)
State 3 histological features of diabetic nephropathy.
Mesangial expansion
Basement membrane thickening
Glomerulosclerosis (hardening of the capillaries)
In diabetic nephropathy you get over production of matrix. What can this be caused by?
Effects of prolonged exposure to high glucose or glycosylated proteins
A rise in pressure within the glomerular capillaries
Angiotensin II
State 3 clinical features of diabetic nephropathy.
Progressive proteinuria
Increased BP
Deranged renal function
What is the normal range for proteinuria?
< 30 mg/24hr
Why do patients with diabetic nephropathy get oedematous?
Increased proteinuria means they are losing albumin through their urine
Decreases serum albumin hence decreases the osmotic potential of the plasma so less fluid is drawn back into the circulation
Describe 4 strategies for intervention of patients with diabetic nephropathy.
Improve blood glucose control
BP control
Inhibition of the activity of the RAAS system
Stopping smoking
What effect does angiotensin II have on endothelial cells?
It makes endothelial cells more rigid
Where is renin produced?
Juxtaglomerular apparatus
What can stimulate renin release?
Low renal perfusion (i.e. low BP)
Where is ACE found?
Lungs
State 3 drug target sites in the renin-angiotensin system.
Drugs blocking renin activity
ACE inhibitors
Angiotensin II receptor blockers (ARBs)
What causes diabetic neuropathy?
Occlusion of the vasa vasorum
State 6 different types of diabetic neuropathy.
Peripheral polyneuropathy Mononeuropathy Mononeuritis multiplex Radiculopathy Autonomic neuropathy Diabetic amyotrophy
What can peripheral neuropathy lead to, who is it most common in and how can it be tested?
Loss of sensation can lead to damage going unnoticed
Leads to loss of ankle jerks + loss of vibrational sense
Inappropriate use of joints can lead to Charcot joints
Most common in tall people/ those with poor glucose control
Test: monofilament examination
What is mononeuropathy?
Usually sudden motor loss e.g. wrist drop or foot drop
Can also cause cranial nerve palsy
Why is the pupil spared in pupil sparing third nerve palsy?
Parasympathetic fibres responsible for the diameter of the pupil, run on the outside of the main nerve so they don’t lose their blood supply in diabetes
How would an aneurysm causing third nerve palsy present differently to third nerve palsy caused by diabetes?
There would be fixed pupil dilation
Because parasympathetic fibres would also be affected
What is mononeuritis multiplex?
A random combination of peripheral nerve lesions
What is radiculopathy?
Pain over SPINAL nerves
Usually affecting a dermatome on the abdomen or chest wall
What are the effects of autonomic neuropathy on the GI tract?
Difficulty swallowing
Delayed gastric emptying
Constipation/ nocturnal diarrhoea
Bladder dysfunction
What are the effects of autonomic neuropathy on the CVS?
Postural hypotension
Sudden cardiac death
How can you check for autonomic neuropathy?
Measure changes in heart rate due to Valsalva manoeuvre
Normally there is a change in heart rate
Look at an ECG + compare the R-R intervals
What is autonomic neuropathy?
Loss of sympathetic + parasympathetic nerves to GI tract, bladder + cardiovascular system
