Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Chemotherapies - Cancer Drug List for FRCR CO1 > Microtubule inhibitors/ plant alkaloids > Flashcards

Microtubule inhibitors/ plant alkaloids Flashcards

1
Q

What ae the Microtubule ihibitors/plant alkaloids?

A
  • Docetaxel
  • Eribuln
  • Etoposide
  • Irinotecan
  • Paclitaxel
  • Vincristine
  • Vinorelbine
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What is the mechanism of action of docetaxel?

A

Disrupts microtubular network needed for cell division

Promotes tubulin assembly into stable microtubules and inhibits their disassembly - this means they are stabilised and inhibits mitosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What is the distribution of Docetaxel?

A

PPB >95%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

How is Docetaxel metabolised?

A

PY450-3A enxymes

Inactive metbolites only

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

How is Docetaxel eliminated?

A

Bile and faeces

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What is the half life of docetaxel?

A

11 hours

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What are the indications for docetaxel?

A
  • Breast
  • NSCLC
  • Ovary
  • Prostate
  • H&N
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What adverse effects are associated with docetaxel?

A
  • Hair loss
  • Nail loss
  • Rash
  • Diarrhoea
  • Mucositis
  • Nausea and vomiting
  • Fatigue
  • Fluid retention
  • Nueropathy
  • Hypersensitivity - give steroids
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What drusg does docetaxel interact with?

A
  • CYP3A4 inhibitors and acitvatiors
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What is the mechanism of action of Eribulin?

A

Supresses polymerisation of microtubules and sequesters tubulin intononproductive aggregates

G2/M block

From halichrondin B

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

How is eribulin distributed?

A

65% PPB

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

How is Eribulin metabolised?

A

isn’t

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

How is eribulin eliminated?

A

Faeces

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What is the half-life of eribulin?

A

40 hours

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What are the indications for Eribulin?

A
  • Breast
  • Liposarcoma
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What are the adverse effects of eribulin?

A
  • Hair loss
  • Constipation/diarrhoea
  • N&V
  • LFTs
  • Neuropathy
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

What drugs does eribulin interact with?

A
  • Prolong QT
  • Upset electrolytes
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

What is the mechanism of acion of Etoposide?

A
  • ssDNA breaks
  • Ihibits topoisomerase II

S and G2 phase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

What is the asorption of Etoposide?

A

50% oral bioavailability

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

How is Etoposide distributed?

A

95% PPB
Extensive distribution in saliva, liver, spleen, kidneys, heart, brain

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

How is Etoposide metabolised?

A

p450 - CYP3A4

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

How is etoposed eliminated?

A

50% urine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

What is the half life of etoposide?

A

11 hours IV
6.8 hours PO

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

What are the indications for Etoposide?

A
  • Small and NSCLC
  • Lymphoma
  • Testicular
25
Q

What are the adverse effects of Etoposide?

A
  • cause secondary AML
  • Hair loss
  • Diarrhoea, abdo pain, anorexia
  • Thrombocytopenia
  • PRES
26
Q

What drugs does etoposide interact with?

A
  • Vincritstine
  • Cyclosporine
  • CYP3A4 inhbitors eg. ketoconazole
  • Warfarin
  • Grapefruit
27
Q

What is the mechanism of action of Irinotecan?

A
  • Topoisomerase I inhibitor
  • Active metabolite SN-38
  • Prevents re-ligation of single strand DNA breaks
  • S phase
28
Q

What is the distribution of Irinotecan?

A

70% plasma protein bound
95% PPB SN-38

29
Q

How is Irinotecan metabolised?

A

Carboxylesterase in liver/gut
Active metabolite SN-38

30
Q

How is Irinotecan eliminated?

A

Bule

31
Q

What is the half life of irinotecan?

A

6-12 hours
8-17 SN-38

32
Q

What are the indications for irinotecan?

A

Metastatic bowel cancer
Other GI cancers

33
Q

What are the adverse effects of Irinotecan?

A
  • Bradycardia
  • Flushing
  • Alopecia
  • Abdo pain, diarrhoea, wind
  • N&V
  • Fatigue
  • Myelosuppression
34
Q

What are some drug interactions with irinotecan?

A
  • Steroids
  • CYP3A4
35
Q

What is the mechanism of action of paclitaxel?

A
  • Promotes assembly of microtubules and prevents their depolymerisation
  • Blocks cell cycle late G2/M
36
Q

What is the distribution of paclitaxel?

A

89% plasma protein bound

37
Q

How is paclitaxel metabolised?

A

Liver - cyp 2c8 AND cyp 3a4

38
Q

How is paclitaxel eliminated?

A

Bile

39
Q

What is the half life of paclitaxel?

A

10 hours

40
Q

What is paclitaxel used for?

A
  • NSCLC
  • Breast
  • Ovarian
41
Q

What are the adverse effects of paclitaxel?

A
  • Reactions
  • Arrhythmia
  • Alopecia
  • Diarrhoea
  • mucositis
  • Peripheral neuropathy
  • MSK pain
42
Q

What are the interactions with paclitaxel?

A
  • CYP3A4
  • Radiation
  • Cis/Dox/Epi/Cyc
43
Q

What is the mechanism of action of vincristine?

A
  • Binds to spindle proteins
  • S phase
  • Arrest in metaphase
  • Inhbit RNA synthesis
44
Q

What is the distribution of vincristine?

A

75% Plasma protein bound

45
Q

How is vincristine metabolised?

A

Liver CYP3A5

46
Q

How is vincristine eliminated?

A

30% bile
20% urine

47
Q

What is the half life of vin cristine?

A

Alpha - 5 min
Beta - 2.5 hours
Gamma - 85 hours

48
Q

What are the indications for vincristine?

A
  • NSCLC
  • Breast
  • Cervical
49
Q

What are adverse effects of vincristine?

A
  • Alopecia
  • Weird neuropathy stuff - constipation, eyes, peripheral, retention
50
Q

What are the drug interactions of vincristine?

A
  • Digoxin
  • CYP3A4
51
Q

What is the mechanism of action of Vinorelbine?

A

Binds to tubulin and inhbits microtubule assembly, prevents mitosis and causes cell death

52
Q
A
53
Q

What is the distribution of vinorelbine?

A

90% PPB
Widely distributed

54
Q

How is vinorelbine metabolised?

A

Liver cyp3a4

55
Q

How is vinorelbine eliminated?

A

45% bile
20% urine

56
Q

What is the half life of vinorelbine?

A

25-45 hours

57
Q

What are the indications for vinorelbine?

A
  • NSCLC
  • Breast
58
Q

What are the adverse effects of vinorelbine?

A
  • Pain
  • Neuropathy

otherwise standard

59
Q

What are the drug interactions with vinorelbine?

A
  • CYP3A4
  • Paclitaxel/cis/mito

Chemotherapies - Cancer Drug List for FRCR CO1 (5 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions