Microcytic Hypochromic anemias L3 Flashcards
Symptoms of anemia
Pallor (low blood volume)
Tachycardia (high cardia output)
Fatigue (low O2 transport)
What are the ‘ingredients’ needed to produce healthy RBC?
Iron
Vitamin B12
Folic acid
Normal ranges of red cell indices?
MCV: 80-100 fL
MCH: 25-34 pg
MCHC: 315-355 g/L
What causes IDA?
Lack of iron = abnormal heme synthesis
Blood loss with low dietary iron intake
Peripheral blood findings of IDA?
Microcytic, hypochromic
Codocytes
Low reticulocytes (no stainable iron)
Basophilic stippling
Diagnostic tests results of IDA
Low serum iron
Low ferritin
High TIBC
Inheritance of B+/B genes results in which of the following clinical conditions in the
individual?
a. thalassemia major
b. thalassemia intermedia
c. thalassemia minor
d. no clinical abnormality
c. thalassemia minor
A patient with hypochromic, microcytic anemia has increased serum iron, increased RDW and increased ferritin. What is the most probable diagnosis?
a. lead poisoning
b. sideroblastic anemia
c. anemia of chronic disease
d. thalassemia minor
b. sideroblastic anemia
What causes thalassemias?
Decreased or absent synthesis of globin chains
Peripheral blood findings of Cooley’s anemia?
Microcytic, hypochromic
nRBC
Lower reticulocytes (increased destruction of RBC)
Poikilocytosis (codocytes, ovalocytes, Jowell-Jolly, etc)
Sideroblasts
Basophilic stippling
Diagnostic result for thalassemia major:
High/N serum iron
High/N ferritin
N TIBC
Increased HgF
Peripheral blood findings of hemoglobin H disease
Microcytic, hypochromic
codocytes
Increase reticulocytes
Hemoglobin H
How to differentiate IDA with ACD?
Ferritin is N or increased in ACD
TIBC is decreased in ACD
ACD is not diet related
What causes sideroblastic anemias?
Excess iron which are deposited in normoblasts
Diagnostic results of sideroblastic anemia (in terms of iron, ferritin, TIBC, etc.)
High serum iron
High ferritin
Ringed sideroblasts
N or decreased TIBC
