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Hem/Onc 2 > Microbiology > Flashcards

Microbiology Flashcards

1
Q

What is the CD receptor on B cells where EBV infections?

A

CD21

C3d R

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2
Q

Where are the 2 locations of epithelial cells that are infected by EBV?

A

Oro and nasopahrynx

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3
Q

Which cells does EBV reside in for latent EBV?

A

Memory B cells

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4
Q

After the EBV virus binds to the C3d receptor, what happens to the B cells?

A

It grows

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5
Q

Which proteins do B cells express after being stimualted to grow? (4)

A

EBNAs
Latent Proteins
LMPs 1 and 2
EBER molecules

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6
Q

Which B cell proteins are DNA binding protiens that are essential for establishing an maintaining the infection?

A

EBNA

LPs

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7
Q

Which protein from the B cells is a membrane protein with oncogene-like activities?

A

LMPs

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8
Q

This is the B Cell protein that is transcribed and translated during early genes of the virus and the lytic cycle.

A

ZEBRA transcriptional activator protein

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9
Q

What is the viral attachement protein that promote fusion of the envelope with the cell membrane, which occurs after the synthesis of DNA polymerase and replication of DNA?

A

GP350/220

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10
Q

When do you see the anti EBNA marker?

A

After resolution of infection

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11
Q

When do you see the early Ag?

A

After an infected cell has entered lytic cycle

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12
Q

What are the 2 components of the late VCA protein, which is found in virus-producing cells?

A

Anti-VCA IgM = transient

Anti-VCA IgG = persistent

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13
Q

When do you see the membrane Ag?

A

same as VCA - late protein, in virus producing cells

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14
Q

When do you see the Heterophile Ab?

A

Early, where EBV induces B cell proliferation

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15
Q

An overactive immune response (from T cell) to EBV infection can produce what problem?

A

Infectious mononucleosis (IM)

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16
Q

So what are the 2 problems if there is lack of effecting immune control of EBV infections?

A

Lymphoproliferative disease

Hairy cell leukoplakia

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17
Q

What is the transmission method for EBV?

A

Slaiva (kiss kiss)

:-*

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18
Q

These are the atypical lymphocytes made when Tc cells controls B-cell proliferation, induced by EBV.

A

Downey cells

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19
Q

Is EBV heteophile + or -?

A

+

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20
Q

The B cell activation and proliferation causes a false production of IgM to what Ag, which screens for heterophiles?

A

Paul-Bunnell Ag

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21
Q

True or False: a good way of distinguising EBV from CMV infections is to see if there are Downey cells, as they’e only present in EBV infecitons.

A

FALSE

Theyre in both, but mostly in EBV infections.

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22
Q

This is there condition where there is heterophile +, Sx similar to strep pharyngitis (gray/green throat exudate), extreme fatigue, lympadenopathy, exydate pharyngitis, splenomegaly and splenic rupture.

A

Infectious mononucleosis

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23
Q

Treatment of IM with what drug can cause an erythematous rask because of an allergic rxn?

A

Ampicillin

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24
Q

What are the 2 main complicaitons to IM?

A

Splenic rupture

Neurological complciations

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25
Q

What age group is at most risk for IM?

26
Q

Which pts are at highest risk for life-threatening neoplastic disease in IM?

A

Immunocompromised pts

27
Q

This is the stage of IM where you see heterophile Ab present, mono symptoms, no EBNA, VCA IgM/IgG present, and possible EA.

28
Q

Which of the following markers are present during the Chronic form of IM?

Heterophile Ab, VCA IgM or EBNA, VCA IgG, EA

A

VCA IgG and EA

29
Q

Which of the following markers are present during the latent form of IM?

Heterophile Ab, VCA IgM, VCA IgA, EBNA, VCA IgG, EA

A

VCA-IgA
EA
EBNA**

30
Q

Which of the following markers are present during the PAST INFECTION form of IM?

Heterophile Ab, VCA IgM, VCA IgA, EBNA, VCA IgG, EA

A

VCA-IgA
EBNA

(no EA)

31
Q

This is the condition where there is white crap on the side of the tongue from EBV infections in AIDS pts.

A

Hairy Oral Leukoplakia

32
Q

Where is candida thrush located, which makes it distinguishable from hairy oral leukoplakia?

A

Thursh is at the back of the throat

33
Q

What does EBV do to B cells in lymphoproliferative disease?

A

Stimulates and immoralizes them

34
Q

This is the monoclonal B-cell lymphoma of the jaw and face from chromsosomal transplaction of the cMYC oncogene to have a very active promoter.

A

Burkitts lymphoma

35
Q

In burkitts lymphoma, who is at risk?

A

African kids

36
Q

What co-infection must be present in Burkitts lymphoma?

37
Q

True or False: Burkitts lymphoma is curable with steroids.

38
Q

What do people lack to cause B cell lymphoma, instead of IM?

A

T-cell immunity

39
Q

This is the lymphoproliferative disease that is endemic in adults in Asia, contains EBV DNA, and is of epithelial origin.

A

Nasopharyngeal carcinoma

40
Q

Instead of getting IM, what is the lymphoproliferative disease that transplant recipients can acquire?

A

Post transplant lymphoproliferative disease

41
Q

This is the condition where therea re congenital deficiencies of T-cell fxn (SLAM), where the T cell can control B-cell growth during normal immune response to Ag or because of EBV.

A

X-linked lymphoproliferative disease

42
Q

What is the main site of latency for CMV?

A

Mononuclear lymphocytes

43
Q

How do u get CMV?

A

Blood, tissue, and most body secretions

44
Q

What does CMV do to block the CD8 and CD4 recognition of cells?

A

Downregulating MHC-I

45
Q

What cell type does CMV block from killing the cell by fooling that it does have an MHC-I?

46
Q

True or False: CMV is the most common viral cause of congenital defects.

47
Q

What is the 2 ways neonates can get CMV?

A

Transplacental

Viral ascent from cervix

48
Q

How does a baby/child get CMV?

think secretions.

A

Boob milk, saliva, tears, and urine

49
Q

What are the 3 ways adults can get CMV infections?

A

STD, blood transfusions, organ graft

50
Q

What are the manifestations of congenital infection of the neonate?

A 
Low birth weight
Thrombocytopenia
Intercerebral calification
Microcephaly
Jaundice
Hepatosplenomegaly
Hearing loss
MR
51
Q

What food does a baby look liek when there is cytomegalic includions all over the body from CMV infections?

A

A blueberry muffin

52
Q

This is the condition where there is heterophile negative mono, possible Downey cells, and signs of hepatitis.

A

Mononucleosis

from CMV

53
Q

What is the #1 problem of CMV infections in IC pts?

54
Q

True or False: CMV is the most responsible for kidney transplant failures in organ transplants.

55
Q

So which mononucleosis is heterophile +, EBV or CMV?

56
Q

This is the sign on CMV where there is an enlarged cell with basophilic intranuclear includion bodies.

A

Owl’s eye inclusion

57
Q

What are the 2 tests u can do to screen for the CMV viral Ag for Dx?

A

IF or ELISA

58
Q

What is the Tx for severe CMV infection in IC pts?

A

Ganciclovir

59
Q

What other drugs can u give for CMV infections?

A

Valganciclovir
Cidofovir
Foscarnet

60
Q

This is an opportunistic infection in AIDS pts, where a virus infects a limited # of endothelial cells, monocytes, eithelial and sensory nerve cells, and causes neoplasms.

A

Kaposi sarcoma

HHV-8

61
Q

What is the rare type of B-cell lymphoma from HHV-8 infections?

A

Primary effusion lymphoma

Hem/Onc 2 (5 decks)

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