Microbial Sensing of Host Environment Flashcards
Features and mechanisms of two-component systems PhoPQ, PmrAB in Salmonella species Other regulatory systems contribute to the plasticity of PhoPQ and PmrAB
1
Q
Function of TCSs
A
They facilitate the adaptive response of bacteria to diverse environmental stimuli
2
Q
Process of TCSs
A
Simple:
- Signal detected by histadine kinase (homodimer)
- HK autophosphorylates by histadine catalytic domain
- Aspartic Acid and Response Regulator are phosphorylated by HK which are now activated
- The response regulator is a DNA binding protein that influences expression of genes
