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RECALLS > MICRO PARA QUIZ 3 - Gen. Properties of Viruses/Pathogenesis and Control of Viral Diseases/PARVOVIRUS AND ADENOVIRUS > Flashcards

MICRO PARA QUIZ 3 - Gen. Properties of Viruses/Pathogenesis and Control of Viral Diseases/PARVOVIRUS AND ADENOVIRUS Flashcards

1
Q

All of the following are caused by Adenoviruses, except?

Glomerulonephritis
Gastroenteritis
Conjunctivitis
Pneumonia

A

Glomerulonephritis

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2
Q

Effect of B19 parvovirus on fetus:

Hydrops fetalis
Pure red cell aplasia
Fifth Disease
Erythema Infectiosum

A

Hydrops fetalis

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3
Q

What type of specimen would be most appropriate for detection of adenovirus types 40 and 41 infection?

Blood
Urine
Stool
Swab

A

Stool

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4
Q

Bocavirus is detected in which of the following:

Respiratory secretion
Urine
Bone marrow
Fetal liver

A

Respiratory secretion

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5
Q

A 5 yo male child had onset of cough, nasal congestion, fever, and sore throat for 2 days, you suspect that the etiologic agent is an Adenovirus, which specific group of Adenoviruses does the etiologic agent belong?

Group E
Group C
Group B
Group A

A

Group C

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6
Q

Major sites of Parvovirus replication include:

fetal bone marrow
ALL blood cells
fetal liver
CNS

A

fetal liver

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7
Q

Which among these blood type is at risk for acquiring Parvovirus B19 infection:

Duffy
Lewis
P
ABO

A

P

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8
Q

Principal targets for human B19 parvovirus?

Immature cells in the erythroid series
Mature RBC
Platelets
Immature Leukocytes

A

Immature cells in the erythroid series

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9
Q

Mode of Transmission of Parvovirus:

Vertical
Parenteral
Respiratory
All are correct

A

Respiratory

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10
Q

a 30 yo G2P1 (1001) 19 weeks Age of Gestation, mother came into your clinic, showing signs and symptoms of Parvovirus B19 Infection, what is the probable outcome of her pregnancy:

Fetal demise
All are correct
Healthy baby
Baby will produce antibody against B19

A

Fetal demise

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11
Q

Treatment of Adenoviruses infection:

None
Remdesivir
Azithromycin
Cefuroxime

A

None

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12
Q

Property/ies of Adenoviruses:

Replication in the cytosol
RNA, linear, 26–45 kbp, protein bound to termini, infectious
With envelope
Adenoviruses replicate well only in cells of epithelial origin.

A

Adenoviruses replicate well only in cells of epithelial origin.

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13
Q

TRUE of Erythema Infectiosum (Fifth Disease):

The incubation period is usually 4-5 weeks but may extend to 6 weeks.

Specific IgM antibodies appear about 15 days postinfection.

This erythematous illness is most common in children of early school age and occasionally affects adults. Fever and mild constitutional symptoms may accompany the rash, which has a typical “slapped cheek” appearance

All are correct

A

This erythematous illness is most common in children of early school age and occasionally affects adults. Fever and mild constitutional symptoms may accompany the rash, which has a typical “slapped cheek” appearance

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14
Q

These serotypes of Adenoviruses are etiologically associated with infantile gastroenteritis

Serotypes 15 and 41
Serotypes 40 and 41
Serotypes 10 and 11
Serotypes 30 and 32

A

Serotypes 40 and 41

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15
Q

Types of Adenoviruses that are found most often in bone marrow and renal transplant recipients.

Types 15 and 16
Types 11 and 12
Types 40 and 41
Types 34 and 35

A

Types 34 and 35 cc

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16
Q

These are all enveloped DNA viruses except

Adenosexual roa dna virus
Herpes
Pox
Hepadna

A

Adenosexual roa dna virus

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17
Q

Which of the following is a single stranded DNA virus

Pox
Parvo
Hepadna
Herpes

A

Parvo

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18
Q

A member of Ebola with no mortality rate in humans and found in the Philippines

Ivy Coast
Reston
Zaire
Sudan

A

Reston

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19
Q

Identical to Marburg virus but differ in the antigenecity

Ebola
Option 3
Lassa
Crimean Congo
Hanta

A

Ebola

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20
Q

A DNA virus

Toga
Arena
Bunya
Hepadna

A

Hepadna

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21
Q

Zika virus is a

Hepadna
Flavi
Picorna
Hepe

A

Flavi

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22
Q

The most lethal human pathogen among Arena virus

Marburg
Lassa
All of the above
Rift valley

A

Lassa

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23
Q

Which can inactivate Lassa Fever virus

Detergents
Gamma radiation
UV radiation
All of the above

A

All of the above

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24
Q

An RNA virus of arthropod borne with 3 segments

Arena
Bunya
Flavi
Filo

A

Bunya

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25
Q

Rabies virus is killed rapidly by exposure to :

Sunlight
All are correct cc
Ultraviolet light
Heat (1 hour at 50C)

A

All are correct cc

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26
Q

The organ with the highest titers of virus is:

Parotid gland
Submandibular salivary gland
CNS

A

Submaxillary salivary gland

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27
Q

Pathognomonic for Rabies:

Amyloid deposition
Fear of water
Salivation
Negri body

A

Negri body

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28
Q

Orthomyxoviruses viral transcription occurs in the:

Cytoplasm
Ribosomes
Cell
Nucleus

A

Nucleus

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29
Q

benign epidermal tumor that occurs only in humans . The virus has not been transmitted to animals and has not been grown in tissue culture.

Vaccinia virus
Smallpox virus
Molluscum contagiosum
Variola major

A

Molluscum contagiosum

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30
Q

The most important cause of lower respiratory tract illness in infants and young children:

Parainfluenza virus
Adenovirus
Influenza virus
Respiratory syncytial virus

A

Respiratory syncytial virus

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31
Q

The etiologic agent of Bronchiolitis is:

Respiratory syncytial virus
Adenovirus
Influenza virus
Parainfluenza virus

A

Respiratory syncytial virus

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32
Q

Which of the following is not a nucleic acid based testing for viruses?

Nucleic acid amplification
Strand displacement amplification
Enzyme immunoassay
Polymerase chain reaction

A

Enzyme immunoassay

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33
Q

Prions are sensitive to which of the following:

Dry heat
Phenol
Urea
Formaldehyde

A

Phenol

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34
Q

Which of the following are the contents of Viral transport medium (VTM) contains a buffered salt solution, protein and saccharide nutrients, pH indicator, and antibiotics to inhibit bacterial and fungal conta

Protein and saccharide nutrients
pH indicator and antibiotics
All of the above
Buffered salt solution

A

All of the above

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35
Q

The primary host of Molluscum contagiosum:

Sheep
Monkeys
Cow
Human

A

Human

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36
Q

This is linked to Infectious mononucleosis, nasopharyngeal carcinoma and Burkitt’s lymphoma

HSV-1
HSV-2
Varicella-Zoster
Epstein -Barr virus

A

Epstein -Barr virus

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37
Q

Epstein Barr Virus attaches to the C3d Receptor (CD21) on the surface

NK
B
Null
T

A

B

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38
Q

Exanthem erythema infectiosum is caused by

Parvovirus B19
Cytomegalovirus
Rubella
Herpes simplex

A

Parvovirus B19

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39
Q

PB19 targets what cells

Lymphoblasts
Megakaryoblasts
Erythroblasts
All of the above

A

Erythroblasts

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40
Q

RNA virus with Sandfly morphology

Bunya
Flavi
Arena
Filo

A

Bunya

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41
Q

Marburg and Ebola are examples of

Bunya
Flavi
Filo
Arena

A

Filo

42
Q

Dengue virus is under the classification of what virus

Flavi
Filo
Bunya
Arena

A

Flavi

43
Q

These are all RNA viruses except

Arena
Adeno
Bunya
Delta

A

Adeno

44
Q

RNA viruses that replicate in the nucleus

Delta
Influenza and Retro
Arena
Bunya

A

Influenza and Retro

45
Q

Breakbone fever is caused by

Hanta
Dengue
Chikungunya
Ebola

A

Dengue

46
Q

Which among of the specimens is an acceptable specimen for various types of viruses as confirmation of immunohistochemistry (IHC )or a standalone diagnostic test?

Formalin-fixed, paraffin-embedded (FFPE) tissue
Ethanol fixed, paraffin embbedded tissue
Fresh specimen
All of the above

A

Formalin-fixed, paraffin-embedded (FFPE) tissue

47
Q

Molluscum contagiosum is caused by

poxvirus
poliovirus
herpesvirus
none of the choices

A

poxvirus

48
Q

In smallpox, lesions in the mouth tended to ulcerate and discharge virus at what day of illness?

6-9 days
10-14 days
1-5 days
1 month

A

6-9 days

49
Q

The incubation period of variola (smallpox)

1 month
10-14 days
1-5 days
6-9 days

A

10-14 days

50
Q

The natural reservoir of cowpox:

Deer
Rodents
Cows
Humans

A

Rodents

51
Q

It is an occupational disease of sheep and goat handlers facilitated by skin trauma.

Smallpox virus
Adenovirus
Vaccinia virus
Orf virus

A

Orf virus

52
Q

Replication site of Picornaviruses:

Nucleus
Ribosome
Cytoplasm
Host cell

A

Cytoplasm

53
Q

These are the largest and most complex of viruses infecting humans.

Poxvirus
Picornaviruses
Coronaviruses
Rhinoviruses

A

Poxvirus

54
Q

The primary host of Molluscum contagiosum:

Sheep
Monkeys
Cow
Human

A

Human

55
Q

The etiologic agent of smallpox?
Yabapox
Variola
Vaccinia
Orf

A

Variola

56
Q

The portal of entry of variola virus :

Upper Respiratory Tract
GI Tract
Skin
CNS

A

Upper Respiratory Tract

57
Q

After viral entry of the Variola virus, primary multiplication occurs in the:

CNS
Lymphoids
Skin
Reticuloendothelial system

A

Lymphoids

58
Q

The only RNA virus which is a double stranded

Reovirus
Retrovirus
Picornavirus
Arenavirus

A

Reovirus

59
Q

Hepatitis A is a

Picornavirus
Hepadna
Flavivirus
Hepevirus

A

Picornavirus

60
Q

These are the only DNA viruses that replicate in the cytoplasm

Influenza viruses
Adenoviruses
Polyomaviruses
Poxviruses

A

Poxviruses

61
Q

All RNA viruses are single stranded except

Arenavirus
Delta virus
Bunyavirus
Reovirus

A

Reovirus

62
Q

This RNA virus has 12 segment double strand.

Adenovirus
Reovirus
Bunyavirus
Orthomyxovirus

A

Reovirus

63
Q

Which of the following laboratory methods describes below in the diagnosis of viral infection?

Polymerase chain reaction
Serological detection of virus specific antibodies
Next Generation sequencing
Viral culture

A

Polymerase chain reaction

64
Q

Viral respiratory specimens are refrigerated for no longer than

48 hours
72 hours
1 week
3 days

A

72 hours

65
Q

Cary-Blair media transports what type of specimen?

All of the above
Stool
Urine
Respiratory

A

Stool

66
Q

bactericidal for many gram-positive and gram-negative bacteria, including many strains of Proteus, Serratia, and Pseudomonas. Ineffective against streptococci and Bacteroides species. Has been used in serious infections caused by gram-negative bacteria resistant to other drugs.

Tobramycin
Gentamicin
Streptomycin
Amikacin

A

Gentamicin

67
Q

The following are commonly used urinary antiseptics:

Chloramphenicol
Ampicillin
Nalidixic acid
Metronidazole

A

Nalidixic acid

68
Q

The assembly of the virus particle from the manufactured components is a complex process. Some of the particles are released from the cell by budding, but the majority of poxvirus particles

transfer to another cell for further replication
mutate to a more virulent virus
remain within the host cell
die

A

remain within the host cell

69
Q

Primary host of ORF Virus:

Cow
humans
rodents
Sheep

A

Sheep

70
Q

Replication site of Poxvirus:

Mitochondria
Golgi apparatus
Cytoplasm
Nucleus

A

Cytoplasm

71
Q

The portal of entry of variola virus:

break in the skin
ingestion
mucous membranes of the upper respiratory tract
All are correct

A

mucous membranes of the upper respiratory tract

72
Q

when the variola virus enters the body, all of the following will take place EXCEPT:

NO EXCEPTION

transient viremia and infection of reticuloendothelial cells throughout the body

primary multiplication in the lymphoid tissue draining the site of entry

a secondary phase of multiplication in those cells, leading to a secondary, more intense viremia; and the clinical disease.

A

NO EXCEPTION

73
Q

The etiologic agent of contagious pustular dermatitis or sore mouth infection.

Tanapox
Molluscum contagiosum
Variola
Orf virus infection

A

Orf virus infection

74
Q

How to diagnose Molluscum contagiosum?

Electron Microscopy
Clinical
PCR
Culture

A

Clinical

75
Q

Diagnosis

Smallpox
Tanapox
Molluscum contagiosum
Herpes infection

A

Molluscum contagiosum

76
Q

Natural host of Tanapox virus?

Sheep
Monkey
Cow
Human

A

Monkey

77
Q

The picornavirus replication cycle occurs in the:

Endoplasmic Reticulum
Nucleus
Cytoplasm of cells
Golgi apparatus

A

Cytoplasm of cells

78
Q

Diagnosis

Cowpox
Smallpox
Molluscum contagiosum
Chickenpox

A

Smallpox

79
Q

Diagnosis

Smallpox
Cowpox
Molluscum contagiosum
Chickenpox

A

Molluscum contagiosum

80
Q

Portal of entry of Poliovirus:

Skin
Mouth
Respiratory
GIT

A

Mouth

81
Q

transient inhabitants of the human alimentary tract and may be isolated from the throat or lower intestine

Rhabdoviruses
Rhinoviruses
Adenoviruses
Enteroviruses

A

Enteroviruses

82
Q

Virus associated with the respiratory tract and isolated chiefly from the nose and throat.

Rhabdoviruses
Adenoviruses
Enteroviruses
Rhinoviruses

A

Rhinoviruses

83
Q

Incubation period of Poliovirus:

1 month
7-14 days
1-5 days
21 days

A

7-14 days

84
Q

Most common form of Polio wherein the patient has only a minor illness, characterized by fever, malaise, drowsiness, headache, nausea, vomiting, constipation, and sore throat in various combinations. The patient recovers in few days.

Mild disease
Moderate disease
Paralytic poliomyelitis
Nonparalytic poliomyelitis

A

Mild disease

85
Q

The predominating complaint is flaccid paralysis. The amount of damage varies greatly. Maximal recovery usually occurs within 6 months, with residual paralysis lasting much longer.

Moderate disease
Paralytic poliomyelitis
Mild disease
Nonparalytic poliomyelitis

A

Paralytic poliomyelitis

86
Q

The incubation period of coxsackievirus infection

1-5 days
2-9 days
more than 14 days
7-14 days

A

2-9 days

87
Q

This virus has been isolated from patients with Meningitis, encephalitis, and paralysis resembling poliomyelitis.

Enterovirus 70
Enterovirus 69
Enterovirus 71
Enterovirus 72

A

Enterovirus 71

88
Q

In China, Hand-foot-and-mouth disease is caused by:

Enterovirus 71
Enterovirus 72
Enterovirus 70
Enterovirus 69

A

Enterovirus 71

89
Q

TRUE of RHINOVIRUSES, EXCEPT:

Replication is limited to the surface epithelium of the nasal mucosa.
They are associated with the majority of acute asthma exacerbations
ALL ARE CORRECT
Virus enters via the upper respiratory tract

A

ALL ARE CORRECT

90
Q

emerged as a cause of severe hand-foot-and-mouth disease, sometimes followed by nail shedding

group B coxsackieviruses
Coxsackievirus A6
coxsackievirus A16
group C viruses

A

Coxsackievirus A6

91
Q

Rhinoviruses grow better at what temperature?

18C
22C
28C
33C

A

33C

92
Q

Most common manifestation/form of Poliovirus infection?

The predominating complaint is flaccid paralysis resulting from lower motor neuron damage.

A recrudescence of paralysis and muscle wasting has been observed in individuals decades after their experience with paralytic poliomyelitis.

stiffness and pain in the back and neck. The disease lasts 2–10 days, and recovery is rapid and complete.

The patient has only a minor illness, characterized by fever, malaise, drowsiness, headache, nausea, vomiting, constipation, and sore throat in various combinations. Recovery occurs in a few days.

A

The patient has only a minor illness, characterized by fever, malaise, drowsiness, headache, nausea, vomiting, constipation, and sore throat in various combinations. Recovery occurs in a few days.

93
Q

They are the most commonly recovered agents from people with mild upper respiratory illnesses. They are usually isolated from nasopharyngeal secretions but may also be found in throat and oral secretions.

Rotaviruses
Rhinoviruses
Poxvirus
Vaccinia virus

A

Rhinoviruses

94
Q

TRUE of poliovirus:

Most strains will infect monkeys when inoculated directly into the brain or spinal cord

Poliovirus does not require a primate-specific membrane receptor for infection, and the absence of this receptor on the surface of nonprimate cells makes them virus resistant.

ALL are TRUE

There are three antigenic types of polioviruses based on epitopes found in the P1, P2, and P3 proteins.

A

Most strains will infect monkeys when inoculated directly into the brain or spinal cord

95
Q

A 20 yo female present with abrupt onset of fever and stabbing chest pain which is preceded by malaise, headache, and anorexia. Based on the history, the chest pain was noted for more than a week now. There is also associated abdominal pain. What do you think is the etiologic agent?

group D coxsackieviruses
group C coxsackieviruses
group A coxsackieviruses
group B coxsackieviruses

A

group B coxsackieviruses

96
Q

chief cause of acute hemorrhagic conjunctivitis:

group B coxsackieviruses
Coxsackievirus A6
Enterovirus 70
coxsackievirus A16

A

Enterovirus 70

97
Q

sequelae of acute hemorrhagic conjunctivitis:

sepsis
None
Blindness
cataract formation

A

None
??

98
Q

Primary multiplication site of Poliovirus?

Intestine
Brain
Mouth
blood

A

Intestine

99
Q

which of the following elements prevents inactivation of Poliovirus?

Iron
sodium deoxycholate
Magnesium
ether

A

Magnesium

100
Q

PB19 targets what cells

Lymphoblasts
Megakaryoblasts
Erythroblasts
All of the above

A

Erythroblasts

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