Micro General Concepts

Question 1

Which bacteria is most commonly found in the colon?

Answer 1

Bacteroides

Question 2

Bacteria which is used in cleaning oil spill? The process is called?

Answer 2

Pseudomonas; Bioremediation

Question 3

What is the basis for the 3 large domains classification of the Archaea, Bacteria and Eukarya?

Answer 3

16s rRNA Sequence

Question 4

These are OBLIGATE INTRACELLULAR but acellular parasites of plants. They have naked RNA and DOES NOT cause HUMAN disease

Answer 4

VIROIDS (Ingestion of these particles will not cause clinical manifestations)

Question 5

These are DNA pieces that move readily from one site to another either within or between DNS of bacteria, plasmids and bacteriophages. Also called “jumping genes”.

Answer 5

TRANSPOSONS (Very important in bacteria’s ability to acquire DRUG RESISTANCE)

Question 6

This is believed to be the most common way of PRION disease transmission?

Answer 6

SPORADIC FORM (Sporadic Fatal Insomnia)

Question 7

Kuru and variant CJD are both acquired forms of prion diseases. How do their manifestations differ clinically?

Answer 7

KURU presents with CEREBELLAR signs (shivering, loss of coordination, unsteady gait) while variant CJD presents with Alzheimer-like symptoms

Question 8

How does PRION infection appear in histologic studies?

Answer 8

VACUOLATED neuron with NO EVIDENCE of INFLAMMATION

Question 9

How is PRION transmitted?

Answer 9

transplantation (CORNEA); ingestion of infected tissue (cannibalism in certain tribes, KURU) ; via INHERITED syndrome

Question 10

An abnormal prion protein is consists largely of which protein structure?

Answer 10

Beta Sheet (PrPc is normal PrPsc is the abnromal form)