Micro

Question 1

yellow fever

Answer 1

causes hepatitis following establishment of viremia

arbovirus transmitted by mosquitoes

Question 2

structure hep A

Answer 2

picornaviridae
+ssRNA
resistant, acid stable
non-enveloped

Question 3

structure hep B

Answer 3

hepadnaviridae

partially ds DNA

Question 4

structure hep C

Answer 4

flaviviridae

+ssRNA

Question 5

structure hep D

Answer 5

deltaviridae

ss circular RNA

Question 6

structure hep E

Answer 6

hepeviridae

+ RNA

Question 7

other viruses capable of causing hepatitis

Answer 7

EBV
CMV
HSV
Rubella (newborns)

Question 8

clinical features hep A

Answer 8

children-mild

adults-more severe

Question 9

spread and replication hep A

Answer 9

fecal oral

multiplies in GI tract causing viremia then to liver, kidney, spleen

Question 10

lab diagnosis hep A

Answer 10

EM

anti HAV IgM

Question 11

treatment hep A

Answer 11

pooled gamma globulin 1-2 weeks after exposure

Question 12

hep A vaccine

Answer 12

inactivated Hep A
recommended for international travelers
two immunizations, first at a year, second 6 months later

Question 13

only infectious particle hep B

Answer 13

Dane particle

Question 14

Dane structure hep B

Answer 14

partial ds DNA
polymerase
surrounded by envelop

Question 15

infectivity antigen

Answer 15

HBeAg

presence indicates infectious virus is present in patient

Question 16

enzymatic function polymerase

Answer 16

DNAP
RT
RNase H-degrades RNA strand of RNA-DNA hybrid

Question 17

replication Hep B

Answer 17

occurs in nucleus and cytoplasm

Question 18

purpose viral RNA

Answer 18

messenger to be translated into proteins

template for viral genome DNA synthesis

Question 19

lab diagnosis hep B

Answer 19

EIA and other antigen-Ab tests
liver biopsy for HbsAg in cytoplasm
blood bank test for HBsAg, anti-HBsAg and HBV DNA

Question 20

Heptavax

Answer 20

preferred if person is allergic to yeast

not glycosylated when produced in yeast

Question 21

treatment baby to mother with HBV

Answer 21

HBIG and vaccine ASAP

alpha interferon pegylated effective in severe cases

Question 22

treatment chronic hep B

Answer 22

injectable interferon alpha
pegylated IF
oral nucleoside analog-lamivudine
nucleotide analog-adefovir, enticavir, telbivudine, tenofovir

Question 23

treatment targets hep C

Answer 23

protease inhibitor
NS5A inhibitor
NS5B inhibitor

Question 24

Hep D

Answer 24

requires HBV as helper

alpha IF temporary benefit

Question 25

Hep E

Answer 25

ssRNA from contaminated drinking water and food

serious in pregnant women