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Laboratory Animal > Mice > Flashcards

Mice Flashcards

1
Q

What is the Genus name of the mouse?

A

Mus

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2
Q

What is the Species name of the mouse?

A

Mus musculus

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3
Q

What Order is the mouse from?

A

Rodentia

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4
Q

What Sub-Order is the mouse from?

A

Myomorpha

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5
Q

What Family is the mouse from?

A

Muridae

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6
Q

What Sub-Family is the mouse from?

A

Murinae

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7
Q

Mice account for what % of procedures involving genetically modified animals?

A

98%

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8
Q

What are the reasons mice are used in labs?

A 
inexpensive
small size
short life span (2-3 years)
can study many generations in short time period
rapid reproduction (19-21 days)
large litter size
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9
Q

What is the life span of mice?

A

2-3 years

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10
Q

What is the gestation period of mice?

A

19-21 days

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11
Q

What are the uses of mice in research?

A 
genetics
breeding
cancer
drug testing
cosmetics
virology
histocompatability (tissue transfer)
congenital defects
aging
radiobiology
diabetes
behavior
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12
Q

What is the average weight of an adult mouse?

A

20-40g

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13
Q

What is the birth weight/condition of mice?

A

1-5g
blind
naked

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14
Q

What is the weaning age of mice?

A

21-28 days

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15
Q

What is the normal temperature for mice?

A

97.5-100.4 F

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16
Q

What is the normal heart rate of mice?

A

325-780 bpm

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17
Q

What is the normal respiration rate of mice?

A

60-220/min

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18
Q

What is the pH of mouse urine?

A

7.3-8.5

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19
Q

What is the USG of mouse urine?

A

1.08

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20
Q

When is puberty for mice?

A

6-8 weeks

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21
Q

How long is the estrous cycle for mice?

A

4-5 days

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22
Q

T or F: Mice are polyestrus because of spontaneous ovulation

A

True

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23
Q

What is the gestation time of mice?

A

19-21 days

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24
Q

What is the litter size of the mouse?

A

1-20

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25
Q

What is the average litter size of mice?

A

6-12

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26
Q

When do mice pups first open their eyes?

A

12-13 days

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27
Q

How long does the vaginal plug persist in mice?

A

18-24 hours

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28
Q

How long is the breeding duration in mice?

A

7-9 months

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29
Q

When is breeding onset for female mice?

A

50-60 days

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30
Q

When is breeding onset for male mice?

A

50 days

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31
Q

The laboratory strains of mice used today are descendants of what?

A

european house mouse (Mus domesticus) with some genes from asian species

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32
Q

What did the mice breeders of the 19th century Europe develop and how did that impact later research?

A

developed the albino and color mutants and began the investigations of varietal characteristics and inheritance that provided stocks for later research

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33
Q

What is the Albino mouse also known as?

A

swiss mouse

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34
Q

What do mice use to feel around and why?

A

external vibrissae

they have poor eyesight

35
Q

What is the name of the gland behind the eye of the mouse and what does it produce?

A

Harderian gland

produces red tears (porphorin, not blood)

36
Q

What is the 1st digit of the mouse forepaw?

A

pollex

37
Q

How is sex determined in mice?

A

ano-genital distance

38
Q

What is the dental formula of mice?

A

2 (I 1/1, M 3/3) = 16

39
Q

What type of incisors do mice have?

A

hypsodont

40
Q

What type of molars do mice have?

A

brachyodont

41
Q

How many mammary glands do mice have?

A

5
3 thoracic
2 abdominal

42
Q

What type of fermentators are mice?

A

hind gut fermentators

43
Q

T or F: Rodents have sweat glands and are able to pant

A

false

44
Q

What is the acceptable environment temperature range for mice?

A

64-79 F

45
Q

What should the environmental humidity range be maintained at?

A

30-70%

average: 50%

46
Q

How many hours of light/day do mice need?

A

12-14

47
Q

How many hours of light/day do mice need for breeding?

A

14 hours of light

48
Q

How far should the bottom shelf of a rack be off the floor?

A

6 in. off the floor

49
Q

What is the most common type of mouse cage?

A

plastic box
12 X 6 X 6 inches
metal lid

50
Q

How much floor space is required for each mouse in a cage?

A

8 sq in per adult mouse

51
Q

What is the ideal construction of a mouse cage?

A

seamless for easy
designed for easy cleaning
confine mice without restricting movement
stackable without binding
light weight yet sturdy
resistant to corrosive effects of mouse urine

52
Q

What should the diameter of the water tube be for mice?

A

1/4 - 3/8 inch

53
Q

What angle must the water tube be placed at?

A

bent at an angle of 105 degrees

54
Q

Where is the tip of the water bottle placed in a mouse cage?

A

2 in. above the floor of the cage

55
Q

What are the 3 purposes bedding material have?

A

provide material from which mice can make nests
absorb fecal and urine wastes
provide insulation

56
Q

What are the most common bedding materials for mice?

A 
wood shavings
ground up corn cobs
chopped straw hay
shredded paper
paper strands
57
Q

How deep should bedding be in mice cages?

A

3/4 in. deep

58
Q

How often should cages be cleaned?

A

atleast once a week

59
Q

What form should mouse food be in?

A

pellets

60
Q

What are factors that influence genetic background on breeding performance?

A

behavior
hybrid vigor
birth defects

61
Q

What are mutation/transgenic associated breeding problems of mice ?

A 
infertility (either gender)
mammary function
embryonic lethality
abnormal behavior
shortened breeding life span
62
Q

What are the non-genetic factors that influence breeding performance of mice?

A

environment (temp, light intensity and light cycle, noise and vibrations, air pressure, odors)
handling consistency
nutrition
health status

63
Q

Data collection and record keeping

A

collect breeding statistics
monitor genotype and gender frequencies for each breeding unit
pedigree records

64
Q

What are the non productive breeder criteria of mice?

A

no litter produced (40 days from date of first mating)
no new litters (40 days from last date born)
no weaned pups (2-3 litters with no wean)

65
Q

What are tips for colony management of mice?

A

mate mice early ( between 7-12 weeks of age)
establish/collect breeding stats
replace breeders on rotation (weekly, monthly)
keep good records, evaluate data regularly
remove non-productive breeders ASAP

66
Q

What is the ideal way to set up a breeding cage?

A

1 male to 2-6 females

67
Q

T or F: Pregnant female mice usually get along

A

true

68
Q

When should mice pups be separated from their mother?

A

1 month old

69
Q

When can tail clipping be done on mice?

A

after 18 days of age

70
Q

What is the proper way to pick up a mouse?

A

grab at base of tail
allow forefeet to grasp edge of cage or table
approach from behind and place forefinger and index finger on either side of neck
hold rest of animal against palm with remaining fingers

71
Q

What is the proper scruffing technique of a mouse?

A

hold at tail base
use forefinger and thumb to gently pin down the head
using the same fingers, grab a sufficent amount of loose skin over the neck
hold the tail with the little finger of the same hand for additional support

72
Q

How much blood can you collect from the tail of a mouse?

A

0.1ml

73
Q

What tools are needed for blood collection from the tail of a mouse?

A 
75% alcohol cotton ball for disinfection
small plastic bottle with 1/2 cm holes in both ends as mouse restrainer
scissors
pipette
vial for blood collection
74
Q

How much blood can be collected from the orbital sinus of mice?

A

up to 0.5ml

75
Q

What tools are needed for blood collection from orbital sinus of mice?

A

75% alcohol ball for disinfection
hypnorm for general anesthetic
27 G needle with 1ml syringe for injection
glass capillary tube and vial for blood collection

76
Q

How much blood can be collected from cardiac puncture in mice?

A

up to 1ml

77
Q

What tools are needed for cardiac punch in mice?

A

75% alcohol cotton ball for disinfection
hypnorm used for anesthetic
27 G needle with 1ml syringe for injection
24 G needle with 3ml syring for blood withdrawl

78
Q

What tools are needed for a saphenous blood draw in mice?

A 
75% alcohol cotton ball
50 ml syringe tube with holes at each end
scalpel and shaver to remove hair
24 G 1in. needle for release of blood
tips and pipette for blood collection
79
Q

How much blood can be collected from the saphenous vein in mice?

A

100 microliters

80
Q

What tools are need for an IP injection in mice?

A

75% alcohol cotton ball

25 G 1/2 in. needle with 1ml syringe for injection

81
Q

What is the maximum amount of fluids that can be given to a mouse at one dose IP?

A

1-2 ml

82
Q

What tools are needed of SQ injection in mice?

A

75% alcohol cotton ball

25 G 1in. needle with 1ml syringe

83
Q

What should the oral feeding in mice be limited to?

A

amount limited to 1% of body weight

84
Q

What tools are needed for oral feeding of mice?

A

18 G stainless steel, ball tipped needle

glove

Laboratory Animal (1 decks)

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