MHU 2022 Flashcards

1
Q

A 70 year old man has developed community acquired pneumonia. What symptom/sign is not a factor in the SMART-COP tool, indicating an increased likelihood for respiratory or inotrope support?
a. Multilobar involvement on chest x-ray
b. Albumin>5.4 g/dL (54 g/L)
c. Confusion
d. Systolic Blood pressure <90 mmHg
e. pH <7.35

A

b. Albumin>5.4 g/dL (54 g/L)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

A 40 year old female had routine blood testing completed and is incidentally found to have a corrected calcium level of 3.4mmol/L. What is the next step in their management?
a. Advise patient to visit their GP in a week for repeat testing
b. Begin IV infusion of zoledronic acid
c. Begin treatment with hydrochlorothiazide
d. Rehydration with 0.9% sodium chloride 4-6 litres over 24 hours

A

d. Rehydration with 0.9% sodium chloride 4-6 litres over 24 hours

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Mr Michael Brown is a 82 year old who has been admitted to the hospital worsening dyspnoea, fever, wheeze and a productive cough which produces yellow sputum. This is on the background of a 20-pack year history and known COPD. You suspect she has an acute infective exacerbation of COPD.
Her past medical history includes Type 2 Diabetes Mellitus which has been well managed for the last 20 years by metformin.
Her Blood Glucose Readings are usually in the range between 4.6-6.0 mmol/L, however her blood glucose level was 14.6mmol/L.
Which of the following drugs would be the most likely cause for elevated Blood Glucose Level?
a) Prednisolone
b) Salbutamol
c) Amoxicillin
d) Paracetamol

A

a) Prednisolone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Your patient is a 68 year old man who complains of right upper quadrant pain. On examination he has asterixis, is jaundiced, and has a large, distended abdomen with a palpable liver edge. He has a history of alcoholism. He has a Child-Pugh score of 15 (Class C).
As a complication of his disease, he has developed hepatic encephalopathy.
The most appropriate course of treatment to treat his hepatic encephalopathy is:
a) Liver Transplantation
b) Transjugular Intrahepatic Portosystemic Shunt
c) Therapeutic Paracentesis
d) Frusemide
e) Lactulose and Rifaximin

A

Lactulose and Rifaximin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

A 30 -old male presents to his GP for a general health check-up one month post Covid-19 infection. On discussion of his history, he tells the GP that he had a previous respiratory illness when he travelled with his partner to see their family in Vietnam one year ago. On this trip he recalls he became mildly ill, coughing with a fever on and off for 3 weeks but was never seen by a doctor.
The GP orders a TB screening test (interferon gamma release assay) as a precaution. This later comes back positive, so sputum samples are taken but when cultured indicate there is no active TB infection.

Considering these results, he is considered to have a latent TB infection and is start on isoniazid, once daily for 6 months.

Which of the following is an important consideration of treatment when prescribing isoniazid?

a) Baseline vision and colour vision testing
b) Renal function
c) Co-prescription of Vitamin B6
d) Co-prescription of an SSRI

A

c) Co-prescription of Vitamin B6

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

68-year-old female patient from a residential care facility presents with a 4 day history of watery diarrhoea. She is under-weight with a BMI of 15.7 and has dry mucous membranes on examination. She has a past medical history of Crohn’s disease and recurrent urinary tract infections that were treated with a cephalosporin due to a penicillin allergy. After she is admitted and examined a CBE and stool sample is sent for testing. Her CBE results show a moderately elevated CRP and WCC and her stool sample is positive for C. difficile
The next day she records a temperature of 38.2 C, she is mildly confused, and her stool sample returns a positive result for C. difficile. She is immediately commenced on oral Vancomycin and monitored for any changes.

In this patient what is the most serious acute complication to monitor for?

a) Toxic megacolon
b) Dehydration
c) Cardiac arrhythmia
d) Sepsis

A

a) Toxic megacolon

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

64-year-old patient with known alcohol related cirrhosis presented with ascites, peripheral oedema and a temperature of 38.1OC. A diagnostic tap revealed a neutrophil count of 400/mm3 (normal <250mm3). Which of the following would be of most immediate benefit?
a) therapeutic paracentesis
b) intravenous antibiotics
c) oral spironolactone
d) trans-jugular intrahepatic porto-systemic shunt
e) fluid restriction and a no added salt diet

A

b) intravenous antibiotics

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Which of the following is true of spontaneous bacterial peritonitis?
a) is characteristically caused by aerobic bacteria
b) is diagnosed by culture of ascitic fluid
c) A mortality rate of 50% is expected at one year
d) is due to intestinal perforation
e) Gentamicin is the treatment of choice

A

a) is characteristically caused by aerobic bacteria

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

A 62 two year old woman came to the ED with sudden onset of severe chest pain, radiating to her left arm. A 12 lead ECG was performed in the ambulance, ST elevation, in lead II, III and AVF.
Her vital as follows: BP: 90/50, Sp O 91% RA, RR: 23, Pulse: 98, temp: 36.7

Which of the following medication would be least likely to be used for the initial management of her symptoms:

A. Morphine
B. 2L Oxygen
C. Nitroglycerin (GTN)
D. Aspirin

A

C. Nitroglycerin (GTN)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

A 71-year-old lady with a history of chronic obstructive pulmonary disease (COPD) presents with progressively worsening shortness of breath and a productive cough. She describes an increase in sputum production with the sputum colour changing from clear to yellow. His arterial blood gas (ABG) results are as follows;

Normal range
pH: 7.22
(7.35 - 7.45)
pO2: 7.4
(10 - 14)kPa
pCO2: 8.6
(4.5 - 6.0)kPa
HCO3: 30
(22 - 26)mmol/l

Her arterial blood gas shows:
a) Type 1 respiratory failure, acute on chronic respiratory acidosis
b) Type 2 respiratory failure, acute on chronic respiratory acidosis
c) Metabolic acidosis with partial respiratory compensation
d) Metabolic alkalosis with partial respiratory compensation

A

b) Type 2 respiratory failure, acute on chronic respiratory acidosisb) Type 2 respiratory failure, acute on chronic respiratory acidosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Which of the following medication classes is LEAST LIKELY to reduce mortality in patients with heart failure with reduced ejection fraction?

a) ACE inhibitors
b) Beta blockers
c) Aldosterone antagonist
d) Diuretics

A

d) Diuretics

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

After presenting to ED with a minimal trauma vertebral fracture, Mrs Jones is found to have persistently raised calcium, mild kidney impairment and low haemoglobin. Which of the following investigations would be most useful to CONFIRM a diagnosis of multiple myeloma?

a) Serum protein electrophoresis
b) Urine Bence-Jones protein
c) CT skeletal survey
d) Bone marrow biopsy

A

d) Bone marrow biopsy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

A 65-year-old female with a known history of long-standing rheumatoid arthritis presents to her GP with a 3-month history of feeling weak, fatigued, and short of breath on exertion. On examination there is pallor of the conjunctivae and palmar creases, and tachycardia. Due to her past history of an autoimmune inflammatory disease such as rheumatoid arthritis, you suspect a diagnosis of anaemia of chronic disease.
What findings on iron studies would confirm your diagnosis?

a) decreased serum iron, increased total iron-binding capacity, decreased transferrin saturation, decreased serum ferritin
b) normal serum iron, normal total iron-binding capacity, normal transferrin saturation, normal serum ferritin
c) decreased serum iron, decreased total iron-binding capacity, normal to decreased transferrin saturation, increased serum ferritin

A

c) decreased serum iron, decreased total iron-binding capacity, normal to decreased transferrin saturation, increased serum ferritin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

A 75-year-old male presents to hospital with acute shortness of breath, palpitations, and fatigue. Once stable, you perform an examination on the patient. On examination he has pitting oedema to both calves bilaterally, a systolic flow murmur and an irregular pulse. A transthoracic echocardiogram is completed which shows a left ventricular ejection fraction of 31%. He is diagnosed with left sided systolic heart failure with reduced ejection fraction (HFeEF).
Which cardiac drug is NOT recommended for heart failure (HFrEF) management?
A. Frusemide
B. Metoprolol
C. Ramipril
D. Verapamil
E. Spironolactone

A

D. Verapamil

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

A 75-year-old male presents to hospital with acute shortness of breath, palpitations, and fatigue. Once stable, you perform an examination on the patient. On examination he has pitting oedema to both calves bilaterally, a systolic flow murmur and an irregular pulse. A transthoracic echocardiogram is completed which shows a left ventricular ejection fraction of 31%. He is diagnosed with left sided systolic heart failure with reduced ejection fraction (HFeEF).
Which cardiac drug is NOT recommended for heart failure (HFrEF) management?
A. Frusemide
B. Metoprolol
C. Ramipril
D. Diltiazem
E. Spironolactone

A

D. Diltiazem

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

A patient with newly developed End Stage Renal Failure has chosen to commence haemodialysis and it is decided they will have a fistula in their forearm. In the next few days following the procedure, what is the most appropriate vascular access for haemodialysis to occur?

a. The Radial-cephalic AV Fistula
b. Internal jugular CVC
c. PICC line
d. Tenckhoff catheter

A

b. Internal jugular CVC

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

A 65 year old man is admitted to hospital after a fall. On day 3 of his hospital admission, he is febrile, with a productive cough and raised neutrophil count. Chest X-ray confirms the diagnosis of hospital acquired pneumonia. He is currently haemodynamically stable. Which of the following antibiotics would be most appropriate for initial treatment?

A. Amoxicillin
B. Piperacillin-Tazobactam
C. Doxycycline
D. Amoxicillin-Clavulanate
E. Vancomycin

A

D. Amoxicillin-Clavulanate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

An 8 year old Indigenous boy presents to the clinic with fever and shortness of breath. His mother says that he has recently recovered from a sore throat. Which of the following examination findings would be most consistent with this presentation?

A. A mid-systolic crescendo-decrescendo murmur heard best in the aortic region, radiating to the carotids
B. Pericardial friction rub on auscultation
C. End-inspiratory crepitations at lung bases
D. A maculopapular rash on the face
E. A pansystolic murmur heard best at the apex and radiating to the left axilla

A

E. A pansystolic murmur heard best at the apex and radiating to the left axilla

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Which antiarrhythmic drug DOESN’T cause negative inotropic effects?
A. Amiodarone
B. Digoxin
C. Verapamil
D. Flecainide
E. Diltiazem

A

B. Digoxin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Which cranial nerves are most likely to be affected in lateral medullary syndrome?
A. 3, 7, 8, 10
B. 5, 7, 8, 10
C. 5, 8, 9, 10
D. 3, 8, 9, 10

A

C. 5, 8, 9, 10

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Mrs Pearce, a 67-year-old women presented to the ED with an acute episode of chest palpitations and dizziness. An ECG was taken, which showed a HR of 145, irregularly irregular rhythm with no P waves. She is currently hemodynamically stable.
PMHx: HFrEF, Hypertension, hypercholesterolaemia, T2DM.
In selecting an acute rate control medication to manage Mr Pearce’s rapid ventricular rate, which of the following pharmacological agents should be chosen?
A) Verapamil 180mg
B) Atenolol 25mg
C) Amiodarone 200mg
D) Digoxin

A

C) Amiodarone 200mg

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

The typical murmur heard in hypertrophic obstructive cardiomyopathy (HOCM) is best described as
a. Crescendo-decrescendo systolic murmur best heard at the at the left sternal border and louder with Valsalva manoeuvre
b. Diastolic murmur best heard in the aortic area with the patient leaning forwards
c. Pansystolic murmur best heard at the left lower sternal border and increased with handgrip
d. Late systolic murmur beginning with a midsystolic click made louder by Valsalva manoeuvre
e. Crescendo-decrescendo systolic murmur best heard in the pulmonic area and made louder by handgrip

A

a. Crescendo-decrescendo systolic murmur best heard at the at the left sternal border and louder with Valsalva manoeuvre

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

A 75-year-old woman presents to the ED via ambulance following a 6-hour history of worsening headache and ataxia. On examination, you notice that the patient has right-sided ptosis, miosis, and anhidrosis, as well as left-sided loss of sensation to temperature. Further, she has a reduced gag reflex, and is struggling to swallow water when instructed. You suspect that she is likely suffering from a stroke, what artery is most likely to be affected?
a) Left PICA
b) Right PICA
c) Left AICA
d) Right AICA
e) Right MCA

A

a) Left PICA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

A 5YO male presents to the ED with a 1-day history of headache, nausea and fever. Physical examination shows a temperature of 39.9ºC and involuntary flexion of the knees when the neck is flexed. CSF analysis shows increased neutrophils and decreased glucose, and CSF gram stain shows gram-negative diplococci. This patient is at risk of which of the following complications?
a. Acute pancreatitis
b. Adrenal insufficiency
c. Deep neck abscess
d. Temporal lobe inflammation
e. Vesicular skin rash

A

b. Adrenal insufficiency

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

A 60YO male presents to the ED with a 1-hour history of headache, blurry vision and right leg numbness. On examination, his vital signs are within normal ranges. Neurological examination shows normal power and reflexes, but decreased sensation over the right lower leg. Examination of cranial nerves shows loss of the temporal visual field in the right eye with macular sparing. Infarct of which of the following arteries is most likely to have caused this patient’s symptoms?
a. Left superior cerebellar artery
b. Left anterior inferior cerebellar artery
c. Left anterior cerebral artery
d. Left middle cerebral artery
e. Left posterior cerebral artery

A

e. Left posterior cerebral artery

26
Q

What is the most appropriate first line of management in a patient with peaked T waves on ECG and a potassium of 6.7? (RR 3.8 - 4.9)

A) Fluid resuscitation
B) IV bolus of short acting insulin + glucose
C) sodium polystyrene sulfonate
D) IV calcium gluconate

A

D) IV calcium gluconate

27
Q

Which of the following agents has no proven mortality benefits for the treatment of congestive heart failure?

A) Bisoprolol
B) Frusemide
C) Perindopril
D) Spironolactone

A

B) Frusemide

28
Q

A 69-year-old male presents to the ED with an infective exacerbation of COPD. He has a pack year history of 38, he has taken 6 puffs of salbutamol which has not relieved his symptoms. He has no red flags requiring ICU admission and is not on a LAMA. What medication should be provided in the next step in immediate management?
a) Glyceryl trinitrate
b) Prednisolone
c) Ipratropium
d) Amoxicillin
e) Doxycycline

A

c) Ipratropium

29
Q

A 32 year old female patient on the ward admitted for pneumonia has recently developed moderate diarrhoea after a course of antibiotics. Stool cultures return positive for Clostridioides difficile. This is the patient’s first episode of a C. difficile infection and there are no features of a severe infection. What is the first line treatment for the patient?
a) Faecal microbiota transplant
b) Metronidazole
c) Vancomycin
d) Wait and watch
e) Clarithromycin

A

b) Metronidazole

30
Q

A 60-year-old male presents to the Emergency department with an acute onset of persistent, severe epigastric pain radiating to the back. He has felt sweaty and vomited three times since the pain started. He explains drinking an entire bottle of wine in the last 24hrs and has had nothing to eat due to loss of appetite. In the ED a workup is done including physical assessment, bloods and imaging.

Which of the following combinations of features of his presentation would be diagnostic of acute pancreatitis?

a. CT scan demonstrating focal enlargement of pancreas and deranged LFTs

b. serum amylase level 3 times greater than upper limit and predisposing factor of recent alcohol intake

c. abdominal pain consistent with acute pancreatitis and serum lipase level 3 times greater than the upper limit

d. ultrasound imaging demonstrating enlarged hypoechoic pancreas and peripancreatic fluid

e. serum amylase level 3 times greater than upper limit and predisposing factor of recent alcohol intake

A

c. abdominal pain consistent with acute pancreatitis and serum lipase level 3 times greater than the upper limit

31
Q

A young mother brings her 4-year-old son to her GP after noticing increased frothiness in his urine in the past 2 days. Upon further questioning, she states that his abdomen and legs have become noticeably swollen. Which of the following is the most likely cause of nephrotic syndrome in this child?
a. Membranous nephropathy
b. Focal segmental glomerulosclerosis
c. Minimal change disease
d. Diabetic nephropathy

A

c. Minimal change disease

32
Q

Mr JH, a 55-year-old man, presents a three-month history of alternating bowel habits and weight loss of 8kgs. Which of the following is the most appropriate investigation?
a. FOBT
b. Colonoscopy
c. CT abdomen
d. CEA

A

b. Colonoscopy

33
Q

You are the intern working in the emergency department. A 15-year-old female comes complaining of a headache with neck stiffness and fever. You are suspicious of meningitis and upon exam, you notice her GCS is continuing to decline since her arrival. What is the most appropriate next step for this patient?
A. Administer empiric antibiotics therapy and dexamethasone
B. Perform lumbar puncture
C. Perform neuroimaging
D. Administer dexamethasone then perform lumbar puncture

A

A. Administer empiric antibiotics therapy and dexamethasone

34
Q

You are a medical student on placement in the ED. The intern has just seen a 29-year-old female with high fever, chest pain and severe malaise who she suspects may have infective endocarditis. The patient has no underlying medical conditions but is an active IVDU. The intern states the patient has a new heart murmur and has asked you to examine and identify the murmur. Which valve are you expecting to have a murmur in this particular patient based on her history?
A. Aortic
B. Pulmonary
C. Tricuspid
D. Mitral

A

C. Tricuspid

35
Q

A 76 year old woman presents to the GP for review of her diabetes. She has type 2 diabetes mellitus and started metformin 12 months ago. Her HbA1c result today has come back as 7.6%. You decide to start her on an additional medication empagliflozin for additional diabetic control.
What is the MOA of this new medication?
a) Sulfonylurea
b) GLP-1 agonist
c) Thiazolidinediones
d) SGLT-2 inhibitor
e) Biguanide

A

d) SGLT-2 inhibitor

36
Q

A 65 year old man presents to ED with a one day history of haematuria. On examination he has a blood pressure of 150/97 and periorbital oedema, but otherwise unremarkable. Upon questioning, he recalls a red itchy rash on his leg that he noticed 6 weeks ago but has since resolved. Urinalysis revealed proteinuria 2+ and haematuria 2+. If a renal biopsy is to be done, what would you expect to find on immunofluorescent microscopy?
a. Mesangial IgA deposits
b. Subepithelial IgG and C3 deposits in a starry sky pattern
c. Linear IgG and C3 deposits along the glomerular basement membrane
d. Diffuse IgG, IgM, IgA and C3 deposits (full-house pattern)
e. No abnormalities

A

b. Subepithelial IgG and C3 deposits in a starry sky pattern

37
Q

A 55 year old man presents with sudden onset dyspnoea and a dry cough. He reports no chest pain, fever, or lower limb swelling. There were reduced breath sounds and dull percussion over the right lung base. A chest x-ray was done showing costophrenic angle blunting, and opacification over the right lung base. A thoracocentesis was performed drawing out blood-tinged pleural fluid, analysis showed a pleural fluid protein to serum protein ratio of 0.4 and a pleural fluid LDH to serum LDH ratio of 0.8. What is the most likely cause of his presentation?
A. Empyema
B. Left sided heart failure
C. Lung cancer
D. Nephrotic syndrome
E. Pulmonary embolus

A

E. Pulmonary embolus

38
Q

86-year-old male comes in after a fall along with a 12-month history of cognitive decline from home. He did not sustain any serious injuries from the fall and he did not hit his head. On examination he is hemodynamically stable and afebrile. There is some mild cogwheeling rigidity bilaterally and no resting or intention tremor present. There is also no dysdiadochokinesis. He has a broad-based shuffling gait, and vertical gaze palsy. Which of the following is the most likely diagnosis?

a) Multiple system atrophy
b) Parkinson’s disease
c) Progressive supranuclear palsy
d) Vascular dementia
e) Brain-stem stroke

A

c) Progressive supranuclear palsy

39
Q

DVT management for patient with high bleeding risk?
a) apixaban
b) warfarin
c) aspirin
d) enoxaparin

A

d) enoxaparin

40
Q

A 76-year-old man presents to his G.P complaining of feeling more lethargic than usual over the past few weeks. His past medical history includes hypertension, congestive heart failure, and lung cancer, which was diagnosed 3 years ago. After thoroughly examining the patient, the G.P orders baseline laboratory studies which have all came back largely unremarkable, but the electrolyte results show that the patient has hyponatremia.

Q1. Which of the following changes in fluid balance would be suggestive of SIADH?

a) Decreased serum osmolality, increased total body sodium
b) Normal serum osmolality, normal total body sodium
c) Decreased serum osmolality, normal total body sodium
d) Decreased serum osmolality, decreased total body sodium

A

c) Decreased serum osmolality, normal total body sodium

41
Q

A 22 year old woman presents to ED with a 10 x10 cm of warm, erythematous skin surrounding a small cut on the outer aspect of her thigh she received while hiking 3 days ago. She has no known allergies. Which of the following antibiotics would be the most appropriate initial choice in treating this patient.
A) Gentamycin
B) Vancomycin
C) Metronidazole
D) Flucloxacillin
E) Ciprofloxacin

A

D) Flucloxacillin

42
Q

A 79 year old woman is admitted after a 3 day heat wave due to dehydration. Her serum creatinine level is found to be 143. Her medication list includes Ramipril, Paracetamol, Zoledronic acid, Sertraline and a Vitamin D supplement. Which of the following would be the most important to suspend on admission?
A) Ramipril
B) Paracetamol
C) Zoledronic acid
D) Sertraline
E) Vitamin D supplement

A

A) Ramipril

43
Q

A 51 year old male presented to his GP complaining of headache, weakness and nausea. He has a past medical history of type 2 diabetes, depression, hypercholesterolemia and asthma. His blood results are ordered:

Sodium: 124 mmol/L (135-145 mmol/L)
Potassium: 4.0 mmol/L (3.5-5.0 mmol/L)
Bicarbonate: 25 mmol/L (22-28 mmol/L)
Urea: 5.2 mmol/L (2.0-7.0 mmol/L)
Creatinine: 80 µmol/L (55-120 µmol/L)

Which of the following medications that he is taking would most likely explain this result?

a. Ibuprofen
b. Fluoxetine
c. Salbutamol
d. Metformin
e. Atorvastatin

A

b. Fluoxetine

44
Q

A 76 year old lady has been in hospital for the past month following a fall which was complicated by severe pneumonia. She reports a 5 day history of worsening diarrhoea.

Her vitals are:
Blood pressure: 90/50 mmHg
Heart rate: 115/min
Respiratory rate: 24/min
Temperature: 38.2ºC
O2 saturations: 96% on room air

Her stool sample comes back positive for Clostridium difficile (C. Difficile). Upon a CT abdomen and pelvis scan, there was grossly dilated ascending colon with no obstruction revealed.

Which is the best antibiotic treatment for this patients presentation?

a. Oral vancomycin
b. Oral vancomycin and IV metronidazole
c. IV vancomycin and IV metronidazole
d. IV vancomycin and oral metronidazole
e. Oral fidaxomicin and IV metronidazole

A

b. Oral vancomycin and IV metronidazole

45
Q

You are a junior doctor assisting your colleague with taking bloods from a patient. Upon transferring the blood from the syringe to the vial, you accidentally cause a needle-stick injury to yourself. Whilst following your hospitals protocol, to assess the level of concern to yourself regarding blood-borne viruses you send off extra bloods from the patient including Hepatitis B serology, the results of which are as follows:

HBsAg – Negative
Anti-HBs – Positive
Anti-HBc – Positive

Given the above results, what does this say about the patient’s Hepatitis B status?

a) The patient currently has a chronic Hepatitis B infection
b) The patient currently has an acute Hepatitis B infection
c) The patient has never had Hepatitis B, and vaccination should be considered
d) The patient has previously had Hepatitis B, but it has resolved
e) The patient is vaccinated against Hepatitis B

A

d) The patient has previously had Hepatitis B, but it has resolved

46
Q

A 42-year-old man presents to the ED of his local hospital with a headache, fever, neck stiffness and nausea for the past 36 hours.

On examination, he is disorientated and has a fever of 38.7C, with all other vital signs within normal limits.Suspecting bacterial meningitis, the admitting clinician immediately commenced the man on ­­­­benzylpenicillin 2.4g IV 4 hourly and ceftriaxone 2g IV 12 hourly, before running a series of tests. A lumbar puncture has been performed, and as you are about to review the man the nursing staff tell you that he was complaining of a strange sensation of déjà vu before a series of clonic movements of his left arm, and was seemingly not responding to those around him. The episode lasted for only a couple of minutes and has resolved when you see him.

Based on this information, what is the most appropriate step in his management?

a) Cease benzylpenicillin
b) Commence acyclovir IV in addition to current antibiotic therapy
c) Continue current antibiotics and commence on anti-epileptic drug therapy
d) Prescribe a third antibiotic alongside the current regimen
e) Supportive management only alongside current antibiotic therapy; seizures are an expected symptom of bacterial meningitis

A

b) Commence acyclovir IV in addition to current antibiotic therapy

47
Q

Which of these organisms is the most common cause of subacute infective endocarditis?
A. Staphylococcus aureus
B. Cardiobacterium hominis
C. Streptococci Viridians
D. Kingella species

A

C. Streptococci Viridians

48
Q

A 40-year-old woman has been feeling fatigued over the past 3 months. In her early twenties she was diagnosed with Crohn’s disease, and two years ago she had an ileocolic resection. She has not had any recent diarrhoea, has not seen any blood in her stools, no abdominal pain, or any other signs of active Crohn’s. Since being diagnosed with Crohn’s she has consumed a well-balanced diet. What is the most likely explanation of her fatigue?
A. Folate deficiency
B. Iron deficiency
C. Vitamin B12 deficiency
D. Protein deficiency

A

C. Vitamin B12 deficiency

49
Q

A 24-year-old male presents to the emergency department with a severe headache. It came on very suddenly, and he describes it as ‘the worst headache he has ever had’. He feels nauseous and has vomited twice since it began 30 minutes ago, but cannot think of any other symptoms he has been experiencing. Which of the following would be the best initial investigation for assessing this patient’s headache?

a) CT angiography
b) Lumbar puncture
c) Head CT
d) Head MRI

A

c) Head CT

50
Q

A 63-year-old man has been hospitalised with a community acquired pneumonia. On day 3, he is recovering well following appropriate management, however his urine output is low. Investigations are conducted, and it is found that the patient has low serum osmolality, high urine osmolality, and high urinary sodium. Which of the following is the most likely to be the underlying cause of these results?

A. Heart Failure
B. High water intake
C. Nephrotic syndrome
D. Liver cirrhosis
E. Lung cancer

A

E. Lung cancer

51
Q

Ms. Liyan is a 22 year old woman who has just been diagnosed with asthma. Over the last 6 months, she has had mild persistent symptoms, with asthma symptoms occurring 4 times a month. She does not wake at night with symptoms. What is the most suitable treatment to place her on?

A. As-needed SABA
B. As-needed ICS-LABA (e.g. Symbicort)
C. As needed SABA with regular low-dose ICS-LABA (e.g. Symbicort)
D. Regular Medium-dose ICS-LABA
E. As needed SABA with regular medium-dose ICS-LABA (e.g. Symbicort)

A

C. As needed SABA with regular low-dose ICS-LABA (e.g. Symbicort)

52
Q

A 62-year-old man presents to his general practice with increasing shortness of breath. His symptoms are now such that doing daily activities such as cooking and hanging his laundry are limited. He is no longer able to take care of the animals on his farm as he finds it too physically demanding. He finds that he’s not short of breath when he’s sitting on his couch and resting.

Which one of the following is the most approximate measure of his symptoms according to the New York Heart Association classification?
A. Class I
B. Class II
C. Class III
D. Class IV
E. Class V

A

C. Class III

53
Q

A 65 year old lady presented with jaundice and commented that she was passing clay coloured stools. When taking her history, you find that she has also lost 7kg in the last 6 months. She also describes recurrent RUQ abdominal pain that “comes and goes”. On examination, a painless mass was palpable in the RUQ. The most likely differential you have in mind at this stage would be:
A. Heptaocellular carcinoma
B. Biliary colic
C - Hepatitis C
D - Cholangiocarcinoma
E - Head of pancreas tumour

A

D - Cholangiocarcinoma

54
Q

A 75-year-old man presents to the emergency department due to 3 days of watery diarrhoea in which he went to the toilet 10-15 times a day. He has also been experiencing associative abdominal pain over the last 3 days and presents with signs of dehydration such as dry mucous membranes, increased skin turgor and light headedness. On examination he is tachycardic and febrile.

Blood and stool cultures return negative. However Clostridium difficile is detected in stool and toxin is also present.

What medication is most likely to have increased his risk for his current presentation

A) Prednisolone

B) Lansoprazole

C) Perindopril

D) Metoprolol

E) Bendroflumethiazide

A

B) Lansoprazole

55
Q

A 42-year-old woman presents to the emergency department after she woke up 4 hours prior and noticed that half her face was drooping. The facial droop is isolated to the left side of the face and the patient is unable facial expressions such as smiling or closing their eye or wrinkling their forehead on the left side.

On examination, there is a loss of motor function to the forehead and lower portions of the left face as well as the inability to close the left eye, with excessive tearing from the left eye. She has full power and sensation in her upper and lower limbs bilaterally.

The patient has no current medical conditions and no relevant past medical history and is previously a very fit and active person.

Given this information, what is the most appropriate initial management?

A) Administer alteplase

B) Non-contrast CT head

C) Offer reassurance and safety netting advice

D) Prescribe prednisolone

E) Prescribe sodium valproate

A

D) Prescribe prednisolone

56
Q

A patient has been admitted to your cardiology team after suffering from recurrent chest pain on exertion that settles with rest. Vitals show that she has a blood pressure consistently over 140/90 mmHg and is currently on no medications. You make a diagnosis of stable angina and decide to discharge the patient with a script for Amlodipine. What common adverse effect of Amlodipine should you counsel her about?
A. Constipation
B. Cough
C. Hypersensitivity skin reaction
D. Peripheral oedema
E. Worsening of chest pain

A

D. Peripheral oedema

57
Q

A 67 year old male with a history of alcoholic cirrhosis presents to the emergency department with decreased conscious state and asterixis. He is diagnosed with hepatic encephalopathy, what is the most appropriate first line treatment for this patient?
A) Rifaximin
B) IV resuscitation and monitoring
C) Lornithine-L-aspartate
D) Lactulose
E) IV thiamine 300mg

A

D) Lactulose

58
Q

Which of the following is the most appropriate medication to use in a patient with cerebral oedema due to metastatic disease?
A) Furosemide
B) Dexamethasone
C) Prednisolone
D) Insulin
E) Spironolactone

A

B) Dexamethasone

59
Q

A 52-year-old woman has presented to the ED with acute severe ulcerative colitis and has been passing 10-15 bloody stools per day over the last 3 days. Her ECG showed PR prolongation, prominent U waves and flattened T waves. Which electrolyte abnormality is this most likely due to?

A) Hypercalcaemia
B) Hypocalcaemia
C) Hyperkalaemia
D) Hypokalaemia
E) Hyponatremia

A

D) Hypokalaemia

60
Q

An 89 year old man has been brought into the GP clinic by his daughter, who is concerned that he has been more forgetful over the last 2 months, misplacing items, leaving on kitchen appliances, and experiencing visual hallucinations. The patient’s daughter also states the patient has had a tremor for the last year, and has had some rigidity in his upper limbs for a similar length of time. You suspect the patient is suffering from Dementia with Lewy Bodies.

Which of the following MRI findings would support this diagnosis?

A) Hummingbird sign
B) Atrophy of the substantia innominata and hypothalamus
C) Hot cross bun sign
D) Asymmetric cortical atrophy
E) Bilateral atrophy of the basal ganglia

A

B) Atrophy of the substantia innominata and hypothalamus

61
Q

A 65-year-old man presents to the hospital with watery diarrhea, severe crampy abdominal pain and dehydration. His blood test results come back with leukocytosis of 17,0000 cells/mm, elevated creatinine, and positive stool test for C.diff. While waiting for these tests, the nurses noticed that he is hypotensive.
Based on the severity, what is the most appropriate first line management of C.diff infection in hospital?
a) Oral Vancomycin and IV Metronidazole
b) Oral Vancomycin
c) IV Metronidazole
d) Oral Metronidazole
e) Oral Vancomycin, IV Metronidazole, and intracolonic vancomycin

A

a) Oral Vancomycin and IV Metronidazole