MHC Flashcards
BCR
recognizes and binds to free antigen that is part of a larger pathogen or toxin
BCR complexes
- ITAMS
- CD19, CD81, CD21
ITAM
Igalpha
Igbeta
- transduce signals
CD19
transmit and relay signals to cell interior
CD81
transmit and relay signals to cell interior
CD21
transmit and relay signals to cell interior
TCR
recognizes and binds to both antigen-derived peptide and MHC to which peptide is bound
- Peptide sources can be from endogenously or exogenously processed antigens
TCR subunits
alpha and beta each have a constant region and variable region
Major histocompatibility complex
- binding groove of a cell-surface protein
- how TCR recognizes pieces of antigen
MHC
peptide made within the cell—> MHC molecule—>surface
MHC Class 1 and class 2
- membrane-bound glycoprotiens that are related in both structure and function
- Antigen-presenting molecules
- Form stable complexes with peptide ligands
- Display antigen on cellular surface for TCR engagement
- NEED PEPTIDE
Nucleated cells
MHC class 1
APCs or phagocytic cells
MHC class 2
MHC class 1
- Ig family (immunoglobulin domain=sticky domain_
- two peptides (larger transmembrane alpha chain and smaller beta2-microbglobulin protein)
- 8-10 amino acids
MHC class 2
- Ig superfamily
- heterodimeric transmembrane protein (alpha chain and beta chain)
- 13-18 amino acids