Metoclopramide

Question 1

What is metoclopramide an example of?

Answer 1

Antiemetic

Dopamine D2-receptor antagonist

Question 2

metoclopramide - indication

Answer 2

prophylaxis and treatment of nausea and vomiting - in the context of reduced gut motility

Question 3

metoclopramide - adverse effect

Answer 3

Diarrhoea - common

Extrapyramidal syndromes (movement abnormalities) - acute dystonic reaction (such as oculogyric crisis - upward deviation of eyes) - to reduce this effect, metoclopramide should be prescribed for no more than 5 days

Question 4

metoclopramide - contraindication - completely avoid

Answer 4

neonates

intestinal perforation

Avoid in parkinson’s

Question 5

metoclopramide - who do we give metoclopramide with caution to

Answer 5

children

young adults

intestinal obstruction

parkinsons disease

Question 6

metoclopramide - interactions

Answer 6

1) Antipsychotics (increases risk of extrapyrimidal side effects)

2) Dopaminergic agents for parkinsons disease
reduces thier effect.

Question 7

What is meant by extrapyramidal effects?

Answer 7

Symptoms of extrapyramidal effects include an inability to sit still, involuntary muscle contraction, tremors, stiff muscles, and involuntary facial movements.