Methylxanthine

Question 1

2 routes of effect

Answer 1

Inhibits phosphodiesterase 4 (PDE) causing an increase in cAMP

Blocks adenosine receptor antagonizing the effects of bronchoconstriction

Question 2

Use

Answer 2

primary use for prevention of asthmatic attacks

Question 3

Side effects (20 mcg/ml)

Answer 3

nausea
vomiting
nervousness
abdominal discomfort

Question 4

Side effects (25 mcg/ml)

Answer 4

cardiac arrhythmias, hypotension, CNS

Question 5

Side effects (40-100 mcg/ml)

Answer 5

seizures

Question 6

Drug interactions

Answer 6

Mg and Al delay absorption

Cimetidine, allopurinol, erythromycin, cipro, propranolol–> increase levels of
theophylline