Methylergonovine

Question 1

What is the brand/trade name for methylergonovine?

Answer 1

• Methergine

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Question 2

What is the pharmacologic category/class of methylergonovine?

Answer 2

• Uterotonic
• Ergot alkaloid

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Question 3

What is the mechanism of action of methylergonovine?

Answer 3

• binds to serotonin receptors in uterine muscle, increasing intracellular caclium and stimulating contractions

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Question 4

What is the dose of methylergonovine for treatment of uterine atony & hemorrhage?

Answer 4

• 0.2 mg IM (second line after oxytocin)

IV administration is rarely, if ever used

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Question 5

What is the onset of action for methylergonovine?

Answer 5

• IM = 3-5 minutes

_{Anesthesia Guidebook - Episode 19: Anesthesia Top Drawer Run Down - Part 3
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Question 6

What is the duration of action for methylergonovine?

Answer 6

• IM = 2-3 hours

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Question 7

What are two important precautions/contraindications for methylergonovine?

Answer 7

• Preeclampsia or history of hypertension

it also activates alpha-1 receptors and may precipitate severe hypertension

_{Anesthesia Guidebook - Episode 19: Anesthesia Top Drawer Run Down - Part 3
UpToDate - Methylergonovine: Drug Information}