Methotrexate

Question 1

3 uses of methotrexate

Answer 1

DMARD for RA
Part of chemotherapy
Treat severe psoriasis

Question 2

Mechanism of action

Answer 2

supresses the immune system and reduces inflammation

Question 3

How often is methotrexate taken?

Answer 3

Once weekly

Question 4

What should it be taken in conjunction with?

Answer 4

Folic acid

Question 5

How long can methotrexate take to start working?

Answer 5

4-6m

Question 6

How often will blood tests be needed for methotrexate?

Answer 6

Before, then every 2 weeks until therapy stabalised. Then every 2-3m.

Question 7

What is given before starting methotrexate?

Answer 7

pnuemococcal vaccine

Question 8

Main SE of methotrexate (5)

Answer 8

Mouth ulcers
GI upset 
Increased risk of infection 
Alopecia 
Headache

Question 9

what can long term use of methotrexate cause?

Answer 9

hepatic cirrhosis or pulmonary fibrosis

Question 10

Important contraindication for methotrexate

Answer 10

MUST BE AVOIDED IN PREGNANCY

Question 11

Advice around pregnancy and methotrexate

Answer 11

must use effective contraception for 3m after stopping (male and female)

Question 12

Advice around infection and methotrexate

Answer 12

Any sign - stop the medication and go to A&E

Question 13

Methotrexate and alcohol

Answer 13

Drink as little as possible

Question 14

What shouldn’t be taken with methotrexate? (2)

Answer 14

NSAIDS and penicillin