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High Risk Drugs > Methotrexate > Flashcards

Methotrexate Flashcards

1
Q

What is low dose methotrexate used to treat?

A

Rheumatoid Athritis
Chron’s
Severe Psoriasis

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2
Q

When should methotrexate ideally be taken?

A

Once weekly

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3
Q

When should folic acid be taken in regards to methotrexate?

A

NOT on day methotrexate is taken

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4
Q

What side effects are we concerned about with methotrexate?

A

Blood Disorders - sore throat, bruising, mouth ulcers

Liver Toxicity - nausea, vomitting, dark urine, jaundice, itching

Pulmonary Toxicity - SOB, Cough

GI Toxicity - Stomatitis (sore, inflamed mouth) , Diarrhoea

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5
Q

How do we treat methotrexate toxicity?

A

Folinic Acid (calcium folinate)

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6
Q

Monitoring Requirements for Methotrexate

A

Every 1-2 Weeks then Every 2-3 Months:
FBC
Renal function
LFT

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7
Q

When is contraception needed in regards to methotrexate?

A

Use effective contraception during and 6 months after.

Women and Men !!

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8
Q

Drug Interactions with Methotrexate

A

Nephrotoxics

Antifolates (trimethoprim, phenytoin)

Hepatotoxics (rifampicin, antifungals)

Omeprazole/Esomeprazole (increases toxicity)

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High Risk Drugs (2 decks)

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