Method Of Localization of NM Rphxs 2024

Question 1

Compartmental

Answer 1

-Compartmentalized or compartment localization.
-Molecules of interest distributed in an enclosed volume.
-Volume is enclosed in a compartment.

Question 2

Tc-99m sestamibi and Tc-99m tetrofosmin cross cell membranes by lipophilic diffusion

Answer 2

Passive diffusion

Question 3

Passive diffusion

Answer 3

described as a random movement of molecules looking to achieve a uniform concentration

Question 4

Tc-99m Exametazime (HMPAO) and Tc-99m bicisate (ECD)

Answer 4

Passive diffusion

Question 5

Cerebrospinal fluid- Cisternogram (In-111 DTPA)

Answer 5

Compartmental Localization

Question 6

TC-99m DTPA brain imaging

Answer 6

Passive diffusion

Question 7

Blood pool- MUGA and GI bleed (Tc99m RBCs)

Answer 7

Compartmental

Question 8

Secretion of certain substances by the kidney tubular cells into the urine (Tc99m mertiatide for tubule secretion renal imaging)

Answer 8

Secretion

Question 8

Filtration

Answer 8

Transit of molecules through pores (think filters)

Question 9

Glomerular Filtration by kidney for glomerular function renal imaging using Tc-99m DTPA

Answer 9

Filtration

Question 10

I-123 and I131 elevate thyroid function, trapped and organified by

Answer 10

Acrive Transport

Question 11

Rb-82 used in PET myocardial perfusion scans

Answer 11

Active Transport

Question 12

Na+/K+ pump, cardiac imaging using Thallous Chloride Tl-201

Answer 12

Active Transport

Question 12

Lung airways- vent studies (Xe-133)

Answer 12

Compartmental

Question 13

Tc-99m pertechnetate (TcO4-) for thyroid imaging

Answer 13

Active Transport

Question 14

Facilitated Diffusion

Answer 14

Carrier-mediated transport across membranes. Prime example is glucose

Question 15

gastrointestinal tract- Gastric emptying (Tc99m SC)

Answer 15

compartmental

Question 16

secretion of certain substances by the liver in the bile (Tc99m mebrofenin for hepatobiliary imaging)

Answer 16

Secretion

Question 17

peritoneal cavity- Leveen shunt study (Tc99m SC or MAA)

Answer 17

compartmental

Question 18

F-18 FDG enters cells via glucose transporters and is used for PET WB imaging and epilepsy

Answer 18

Facilitated Diffusion

Facilitated
Diffusion
Glucose

Question 19

Active transport

Answer 19

Carrier-mediated transport across membranes. Uses normal operative metabolic pathways in the body. Moves radiopharmaceuticals across cell membranes and into cells.

Question 20

Tc-99m succimer (DMSA)

Answer 20

Active Transport

Question 21

Cell sequestration

Answer 21

process where old or damaged RBCs are removed from the circulation

Question 21

Secretion

Answer 21

Special case of active transport out of glands and other tissues

Question 22

I-123 MIBG for neuroendocrine tumors

Answer 22

Active Transport

Question 23

secretion of hydrochloric acid by the stomach (TcO4-) used for Meckels diverticulum imaging

Answer 23

Secretion

Question 24

Spleen tissue imaging using Tc99m heat damaged RBCs

Answer 24

Cell sequestration

Question 25

capillary Blockade

Answer 25

Refers to micro-embolization (physical trapping) of particles in capillaries and pre-capillary arterioles

Question 26

Tc99m MAA lung perfusion imaging

Answer 26

Capillary blockade