methadone

Question 1

synthetic or natural

Answer 1

synthetic

Question 2

potency as compared to morphine

Answer 2

variable as conversion bw the 2 products is not linear

Question 3

diff in action from morphine

Answer 3

less euphoria and longer doa

Question 4

what receptors does methadone acts on

Answer 4

mu
antagonist of NMDA, norepi, serotonin reuptake inhibitor

Question 5

what kind of pain does methadone treat

Answer 5

nociceptive and neuropathic

Question 6

uses in opioids abuse

Answer 6

Methadone is also used in the controlled withdrawal
of dependent abusers from opioids and heroin. Oral methadone is
administered as a substitute for the opioid of abuse, and the patient is
then slowly weaned from methadone. The withdrawal syndrome with
methadone
is milder but more protracted (days to weeks) than that
with other opioids.

Question 7

pk of methadone

Answer 7

very lipophilic accumulate in fat
long doa
long half life

Question 8

adr

Answer 8

Methadone can prolong the QT interval and cause torsades
de pointes, possibly by interacting with cardiac potassium
channels.