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Cardiologia > Metabolitos y receptores > Flashcards

Metabolitos y receptores Flashcards

1
Q

Factores locales vasocontrictores (arteriolas)

A

Disminucion de temperatura local

Autoregulacion

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2
Q

Factores locales vasodilatores (arteriolas)

A

CO2 aumentado, O2 disminuido, K+ aumentado
Adenosina, lactato
pH bajo
Aumento de temperatura local

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3
Q

Productos endoteliales Vasoconstrictores (arteriolas)

A

Endotelina-1
Liberacion local de plaquetas
serotonina
Tromboxanos A2

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4
Q

Productos endoteliales Vasodilatadores (arteriolas)

A

NO
Kininas
Prostaciclinas

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5
Q

Agentes Neurohumorales circundantes/circulatorios
Vasoconstrictores
(arteriolas)

A 
Epinephrina(exepto en higado y musculo esqueletico)
Norepinephrina
Arginina
Vasopresina
angotensina ll
Endogenous digitalis-like substance
Neuropeptide Y
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6
Q

Agentes Neurohumorales circundantes/circulatorios
Vasodilatadores
(arteriolas)

A 
Epinephrina en musculo esqueletico y higado
Calcitonina G-related protein
Sustancia P
Histamina
Peptido natriuretico atrial
polipeptido vasoactivo intestinal
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7
Q

Voltage-gated Ca+ channels, Cav (contraccion)

A

Despolarisacion-> Voltage-gated Ca2+ channels open -> Ca2+ entry-> ↑ [Ca2+]i

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8
Q

Voltage-gated Na+ channels, Nav (contraccion)

A

Despolarisacion-> Voltage-gated Na+ channels open -> mas despolarisacion -> Voltage-gated Ca2+ channels open -> Ca2+ entry -> ↑ [Ca2+]i

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9
Q

Stretch-activated (SA) nonselective cation channels

constraccion

A

Stretch -> SA channels open -> Despolarisacion -> Voltage-gated Ca2+ channels open -> Ca2+ entry ->
↑ [Ca2+]i

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10
Q

Intercmbiador Na+ Ca2+ , NCX (constraccion)

A

Despolarisacion -> Voltage-gated Na+ channels open

  • > Na+ entry -> ↑ [Na+]i -> Slows Na-Ca2+ exchange
  • > ↑ [Ca2+]i
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11
Q

Endotelina receptor, ET(A) ( contraccion)

A

ET -> Receptor de Endotelina ET(A) -> ↑ Gq/11 -> ↑ PLC

  • > ↑ [IP3]i ->IP3 receptor va a reticulo sarcoplasmico
  • > ↑Ca2+ liberacion -> ↑ [Ca2+]i
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12
Q

Receptor de tromboxanos, TP (contraccion)

A

TXA(2) -> TP receptor :

° ->Ca2+ channels open -> Ca2+ entra -> ↑ [Ca2+]i

°-> ↑ O-(2) -> ↓NO

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13
Q

Adreneric receptor, α 1 (contraccion)

A

Agonista (Norepinephrina) -> Adrenoreceptor α 1 -> ↑Gq

-> ↑PLC -> ↑ [IP3]i -> IP3 receptor va a reticulo sarcoplasmico -> ↑Ca2+ liberacion -> ↑ [Ca2+]i

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14
Q

Muscarinico rec. , M2 (contraccion)

A

Agonista (Ach) ->M2 rec -> ↑Gi -> ↓AC -> ↓[AMPc]i

  • > ↓PKA -> ↓ fosforilacion de MLCK -> ↑MLCK
  • > ↑fosforilacion de MLC
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15
Q

Rec. Purinergico, P2X (contraccion)

A

↑[ATP]0 -> P2X rec(ligando-relacionado a canales de Ca+2-rec. operado por calcio=ROC) -> Ca+2 entra
-> ↑ [Ca2+]i

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16
Q

rec. purinergico (adenosina/tipo P1) A1 (contraccion)

A

↑ [Adenosina]0 -> A1 rec en VSMC en arteriolas renales aferentes -> ↑Gq -> ↑PLC -> ↑ [IP3]i -> IP3 receptor va a reticulo sarcoplasmico -> ↑Ca2+ liberacion -> ↑ [Ca2+]i

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17
Q

NPY rec, Y1R (contraccion)

A

Neuropeptido Y -> Y1R -> ↑Gi -> ↓AC -> ↓[AMPc]i
-> ↓PKA -> ↓fosforilacion de la MLCK -> ↑MLCK ->
fosforilacion de la MLC

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18
Q

Rec. Angiotensina , AT1 (contraccion)

A

ANG ll -> AT1 rec. -> ↑Gq -> ↑PLC -> ↑ [IP3]i ->
IP3 receptor va a reticulo sarcoplasmico ->
↑Ca2+ liberacion -> ↑ [Ca2+]i

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19
Q

Rec. AVP -> rec. V1aR o V1R (contraccion)

A

AVP -> rec. V1a -> Gq -> ↑PLC -> ↑ [IP3]i ->
IP3 receptor va a reticulo sarcoplasmico ->
↑Ca2+ liberacion -> ↑ [Ca2+]i

20
Q

Rec. Serotonina (5-hydroxytryptamina), 5-HT2A o 5-HT2B

contraccion

A

5-HT -> receptor 5-HT2A o 5-HT2B -> ↑Gq -> ↑PLC -> ↑ [IP3]i ->
IP3 receptor va a reticulo sarcoplasmico ->
↑Ca2+ liberacion -> ↑ [Ca2+]i

21
Q

Voltage-gated K+ canales , Kv (DILATACION)

A

Despolarisacion -> Canales dependientes de K+ se abren -> se hiperpolarisa -> Ca+ canales se cierran -> ↓[Ca2+]i

22
Q

Canales de K+ dependientes de Ca+

A

Hiperpolarisacion -> Voltage-gated Ca2+ canales se cierran -> ↓[Ca2+]i

23
Q

Canales de K+ sensibles a ATP , K(ATP)

A

↓[ATP]i -> K(ATP) canales se abren -> Hyperpolarisacion -> Canales de Ca2+ se cierran -> ↓[Ca2+]i

24
Q

RS Bomba de Ca2+, Serca2

A

Activacion de la Serca2 -> ↓[Ca2+]i

25
Q

NO rec., sGC (guanilil cyklasa soluble)

A

NO -> ↑sGC -> ↑[cGMP]i -> ↑PKG -> ↑fosforilacion de MLCK -> ↓MLCK actividad -> ↓fosforilacion de MLC -> ↑Serca2 en RS -> ↓[Ca2+]i

26
Q 
Prostaciclina rec. (PGI2), IP
Prostagladina E2 (PGE2) receptor, EP2 y EP4
A

PGI2 ->IP Rec.
or
PGE2 -> EP2 y EP4 -> ↑Gα -> ↑AC -> ↑[AMPc]i -> ↑PKA -> ↑fosforilacion of MLCK -> ↓MLCK -> ↓fosforilacion de MLC

27
Q

Receptor Adrenergico, β2

A

Agonista(epinephrina) -> Adrenoreceptor β2 -> ↑Gα -> ↑AC -> ↑[AMPc]i -> ↑PKA -> ↑ se fosforila MLCK -> ↓MLCK -> ↓fosforilacion de MLC

28
Q

Histamina rec., H2

A

Histamina -> H2 rec -> ↑Gα -> ↑AC -> ↑[AMPc]i -> ↑PKA -> ↑ se fosforila MLCK -> ↓MLCK -> ↓fosforilacion de MLC

29
Q

Rec. Purinergico, P2Y

A

↑[ATP]o -> P2Y Rec. metabotropico -> ↑Gq -> ↑PLC -> ↑[Ca2+]i -> ↑NOS (enzima) -> se libera NO

30
Q

Rec. Purinergico (adenosina)/tipo P1), A1, A2(A) o (B)

A

↑[Adenosina]o -> A1, A2A o A2B rec on VSMC -> ↑Gα -> ↑AC -> ↑[AMPc]i -> ↑PKA -> Canales K(ATP) se cierran -> Hiperpolarizacion -> canales de Ca+2 dependientes de voltage se cierran ->↓[Ca2+]i -> ↑fosforilacion of MLCK -> ↓MLCK -> ↓fosforilacion de MLC

↑[Adenosina]o -> A1 en celula endotelial -> ↑NOS -> se libera NO

31
Q

VIP rec., VIPR1 y VIPR2

A

VIP -> receptores VIPR1 y VIPR2 -> ↑Gα -> ↑AC -> ↑[AMPc]i -> ↑PKA -> ↑fosforilacion of MLCK -> ↓MLCK -> ↓fosforilacion de MLC
Los dos calaes K+ y Ca2+ dependientes de voltage se abren -> hiperpolarizacion -> Canales de Ca2+ se cierran -> ↓[Ca2+]i

32
Q

Angiotensina rec, AT2

A

ANG ll -> Rec. AT2 -> ↑Gq -> ↑PLC -> ↑[Ca2+]i -> ↑NOS (enzima) -> se libera NO -> ↑Bradikinina -> ↑NOS lll -> se libera NO

33
Q

Receptor de peptido Natriuretico A, NPR1

A

ANP -> rec. NPR1 -> ↑GC -> ↑[GMPc]i -> ↑PKG -> fosforilacion of MLCK -> ↓MLCK -> ↓fosforilacion de MLC
↑SERCA2 en RS -> ↓[Ca2+]i

34
Q

Bradikinina rec. ,B2

A

Bradikinina -> rec. B2R en celula endotelial -> ↑Gq -> ↑PLC -> ↑[Ca2+]i -> ↑eNOS -> se libera NO
↑PLA(2) -> ↑PGI(2) y PGE(2) se libera

35
Q

Agentes VASODILATADORES producidos por celulas endoteliales

A

NO
Factor Hiperpolarizante derivado del endotelio (EDHF)
Prostaciclina (PGI(2))

36
Q

Agentes VASOCONSTRICTORES producidos por celulas endoteliales

A

Endotelina
factor contrictor 1 derivado del endotelio EDCF1
Factor contrictor 2 derivado del endotelio EDCF2

37
Q

↓ PO2

A

↓[ATP]i, ↑ Se liber adenosina, ↑PGI(2) se libera, ↑NO se libera

38
Q

↑PCO2

A

↓pHo

39
Q

↓pH

A

↓pHo

40
Q

↑[K+]o

A

Trasiende hiperpolarisacion -> cierra canales de Ca2+ cdependientes de voltaje.

41
Q

↑[Acido lactico]o

A

Probablemente ↓pH

42
Q

↓[ATP]i

A

se abren canales K(ATP)

43
Q

↑[ATP]o

A

Activan receptores purinergicos P(2)

44
Q

↑[ADP]o

A

Activan receptores purinergicos P(2)

45
Q

↑[Adenosina]o

A

Activan receptores purinergicos P(1)

Cardiologia (1 decks)

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