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Metabolism Of Lipids Flashcards

1
Q

Which hormones signal the gallbladder to release bilesalt and pancreas to secrete digestive enzymes

A

Cholestokinin

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2
Q

Limited digestion of TAG occurs in

A

The mouth by lingual lipase
Stomach by gastric lipase

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3
Q

Chemical digestion of TAG involves

A

The hydrolysis of TAG to form fatty acids and 2monoacylglycerol

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4
Q

Limited digestion of TAG occurs in the mouth and stomach because

A

Of low solubility not the substrate and the chain length of fatty acids

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5
Q

Bulk digestion of TAG occurs where

A

In the lumen of the intestines

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6
Q

Digestion of TAG occurs due to the action of

A

Pancreatic lipase

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7
Q

Pancreatic lipase is secreted along side

A

Colipase and bicarbonate

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8
Q

Bicarbonate aids in

A

Neutralizing the acid that enters the intestines

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9
Q

Colipase aid

A

In binding to the dietary fats and increase the lipase activity of pancreatic lipase

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10
Q

Secretine secrete

A

Biocarbonate sequence

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11
Q

Eaterases remove fatty from compound such as

A

Cholesterol ester and phospholipase A2

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12
Q

Digestion of phospholipid to free fatty acid and lyso phospholipidnis aided by

A

Cholesterol ester and phospholipase A2

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13
Q

Acyglucosyl is impermeable to

A

Water

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14
Q

What helps in the transduction of light heating the retina to visual light

A

Rhodopsin

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15
Q

What cells does not synthesize eicosanoid

A

Erythrocyte cell

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16
Q

What contribute to the release of arachidonic acid

A

Cystosolic phospholipase A2
Secretory phospholipase A2

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17
Q

Eicosanoid exert their function through

A

G protein linked receptors

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18
Q

Primary essential fatty acids are

A

Linoleic acid
Alpha linoleic acid

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19
Q

Secondary essential fatty acids are

A

Arachidonic acid
Ecosapentanoic acid
Docosahexanoic acid

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20
Q

Linoleic acid covelently bind to fatty acids attached to cerebroside to form

A

Acyglucosyl ceramide

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21
Q

Cyclo oxygenase pathway synthesize

A

Prostaglandin
Prostacyclin
Thromboxane

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22
Q

Lipo oxygenase pathway synthesize

A

Leukotrienes
Hydro oxy ecosatetra ionic acid
Lipoxines

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23
Q

Cystosolic phospholipase A2 depends

A

Calcium dependent

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24
Q

Secretory phospholipase A2 depends

A

They are calcium independent

25
Oxygenation of arachidonic acid passes which routes
Cyclo oxygenase Lipo oxygenase P450 epoxygenase Isoprostanes
26
P450 epo oxygenase synthesize
Epo oxyecosatrionic acid Dihydrooxyecosatrionic acid
27
Which factors determine types of ecosanoid to be synthesize
The species The type of cell The cell phenotype Manner in which the cell is stimulated
28
Prostanoid synthesis occur in three steps
Mobilisation of free arachidonic acid from membrane phospholipid Conversion of Arachidonic acid to prostaglandin endoperoxide pgh2 Cell specific conversion of pgh2 to one of the major prostanoid
29
What catalyse the formation of pgh2 from Arachidonic acid and two molecules of oxygen
Cyclo oxygenase
30
When cyclo oxygenase acts on Arachidonic acid it yields
Pgg2 and 2 molecules of oxygen
31
What facilitate the two electron reduction bof 15 hydro peroxyl group of PGG2 to PGH2
Peroxidase
32
Which PGH uses fatty acid such as arachidonic acid as substrate
PGH1
33
Which PGH isoenzymes uses both fatty acid and arachidonic acid as substrate
PGH2
34
What isoenzymes serve as intermediate precursor for synthesis of number of prostaglandin and other prostanoid
PHG2
35
The product of PGG2 and Endo peroxide is converted to
Prostaglandin E2 Prostaglandin F2 Prostaglandin D2 Prostaglandin I2 Thromboxane
36
Which enzymes is capable of self catalysed destruction
Cyclo oxygenase
37
The action of prostanoid are mediated by
G protein linked prostanoid
38
Meaning of N SAID
Non steriodal anti inflammatory drugs
39
Aspirin inhibit
Cyclo oxygenase 1 and cyclo oxygenase 2
40
Indomethacine inhibit
Cyclo oxygenase 1 and cyclo oxygenase 2
41
Ibuprofen inhibit
Cyclo oxygenase 1 and cyclo oxygenase 2
42
Cortisol completely inhibit the transcription of
Cyclo oxygenase 2
43
Arachidonic acid also act as substrate also for
Lipoxygenase pathaway
44
The catalysis of cooperation of oxygen molecules into carbon atom of several double Bond of Arachidonic acid forming ba hydroperoxyl group is aided by
Lipoxygenase
45
Lipoxygenase act on carbon at position
5 ,12,15
46
Polymorphonuclear nucleoside contain
5 lipoxygenase
47
Platelets are rich in
12 lipoxygenase
48
Esinophilic leucocytes primarily contain
15 lipoxygenase
49
They are family of conjugated trienes formed from ecosanoid in leucocytes marked cells platelets and macrophages
Leukotrienes
50
Insertion of diatomic oxygen at carbon 5 of Arachidonic acid to yield 5 hydro peroxylecosatetrationic acid is aided by
5 lipoxygenase
51
Leukotrienes biosynthesis depends solely
On the availability of Arachidonic acid which are released from membrane phospholipid
52
The release of Arachidonic acid from membrane phospholipid are aided
By action of cystosolic phospholipase A2
53
Which leukotrienes constrict smooth muscle cells
Leukotrienes C4
54
Family of tetraenes formed by the combine action of more than one lipoxygenase on Arachidonic acid are
Lipoxyn
55
The activity of epoxygenase in the microsomal system yield
Epoxide
56
Which prostaglandin are vasoconstrictor of renal and other vascular tissue
Prostaglandin F2 alpha
57
Which hormones inhibit lipolysis
Insulin
58
Which hormones stimulate lipolysis
Epinephrine

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