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Elite Brainiacs > Metabolism Of Lipids > Flashcards

Metabolism Of Lipids Flashcards

1
Q

Which hormones signal the gallbladder to release bilesalt and pancreas to secrete digestive enzymes

A

Cholestokinin

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2
Q

Limited digestion of TAG occurs in

A

The mouth by lingual lipase
Stomach by gastric lipase

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3
Q

Chemical digestion of TAG involves

A

The hydrolysis of TAG to form fatty acids and 2monoacylglycerol

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4
Q

Limited digestion of TAG occurs in the mouth and stomach because

A

Of low solubility not the substrate and the chain length of fatty acids

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5
Q

Bulk digestion of TAG occurs where

A

In the lumen of the intestines

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6
Q

Digestion of TAG occurs due to the action of

A

Pancreatic lipase

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7
Q

Pancreatic lipase is secreted along side

A

Colipase and bicarbonate

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8
Q

Bicarbonate aids in

A

Neutralizing the acid that enters the intestines

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9
Q

Colipase aid

A

In binding to the dietary fats and increase the lipase activity of pancreatic lipase

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10
Q

Secretine secrete

A

Biocarbonate sequence

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11
Q

Eaterases remove fatty from compound such as

A

Cholesterol ester and phospholipase A2

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12
Q

Digestion of phospholipid to free fatty acid and lyso phospholipidnis aided by

A

Cholesterol ester and phospholipase A2

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13
Q

Acyglucosyl is impermeable to

A

Water

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14
Q

What helps in the transduction of light heating the retina to visual light

A

Rhodopsin

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15
Q

What cells does not synthesize eicosanoid

A

Erythrocyte cell

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16
Q

What contribute to the release of arachidonic acid

A

Cystosolic phospholipase A2
Secretory phospholipase A2

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17
Q

Eicosanoid exert their function through

A

G protein linked receptors

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18
Q

Primary essential fatty acids are

A

Linoleic acid
Alpha linoleic acid

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19
Q

Secondary essential fatty acids are

A

Arachidonic acid
Ecosapentanoic acid
Docosahexanoic acid

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20
Q

Linoleic acid covelently bind to fatty acids attached to cerebroside to form

A

Acyglucosyl ceramide

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21
Q

Cyclo oxygenase pathway synthesize

A

Prostaglandin
Prostacyclin
Thromboxane

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22
Q

Lipo oxygenase pathway synthesize

A

Leukotrienes
Hydro oxy ecosatetra ionic acid
Lipoxines

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23
Q

Cystosolic phospholipase A2 depends

A

Calcium dependent

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24
Q

Secretory phospholipase A2 depends

A

They are calcium independent

25
Q

Oxygenation of arachidonic acid passes which routes

A

Cyclo oxygenase
Lipo oxygenase
P450 epoxygenase
Isoprostanes

26
Q

P450 epo oxygenase synthesize

A

Epo oxyecosatrionic acid
Dihydrooxyecosatrionic acid

27
Q

Which factors determine types of ecosanoid to be synthesize

A

The species
The type of cell
The cell phenotype
Manner in which the cell is stimulated

28
Q

Prostanoid synthesis occur in three steps

A

Mobilisation of free arachidonic acid from membrane phospholipid
Conversion of Arachidonic acid to prostaglandin endoperoxide pgh2
Cell specific conversion of pgh2 to one of the major prostanoid

29
Q

What catalyse the formation of pgh2 from Arachidonic acid and two molecules of oxygen

A

Cyclo oxygenase

30
Q

When cyclo oxygenase acts on Arachidonic acid it yields

A

Pgg2 and 2 molecules of oxygen

31
Q

What facilitate the two electron reduction bof 15 hydro peroxyl group of PGG2 to PGH2

A

Peroxidase

32
Q

Which PGH uses fatty acid such as arachidonic acid as substrate

A

PGH1

33
Q

Which PGH isoenzymes uses both fatty acid and arachidonic acid as substrate

A

PGH2

34
Q

What isoenzymes serve as intermediate precursor for synthesis of number of prostaglandin and other prostanoid

A

PHG2

35
Q

The product of PGG2 and Endo peroxide is converted to

A

Prostaglandin E2
Prostaglandin F2
Prostaglandin D2
Prostaglandin I2
Thromboxane

36
Q

Which enzymes is capable of self catalysed destruction

A

Cyclo oxygenase

37
Q

The action of prostanoid are mediated by

A

G protein linked prostanoid

38
Q

Meaning of N SAID

A

Non steriodal anti inflammatory drugs

39
Q

Aspirin inhibit

A

Cyclo oxygenase 1 and cyclo oxygenase 2

40
Q

Indomethacine inhibit

A

Cyclo oxygenase 1 and cyclo oxygenase 2

41
Q

Ibuprofen inhibit

A

Cyclo oxygenase 1 and cyclo oxygenase 2

42
Q

Cortisol completely inhibit the transcription of

A

Cyclo oxygenase 2

43
Q

Arachidonic acid also act as substrate also for

A

Lipoxygenase pathaway

44
Q

The catalysis of cooperation of oxygen molecules into carbon atom of several double Bond of Arachidonic acid forming ba hydroperoxyl group is aided by

A

Lipoxygenase

45
Q

Lipoxygenase act on carbon at position

A

5 ,12,15

46
Q

Polymorphonuclear nucleoside contain

A

5 lipoxygenase

47
Q

Platelets are rich in

A

12 lipoxygenase

48
Q

Esinophilic leucocytes primarily contain

A

15 lipoxygenase

49
Q

They are family of conjugated trienes formed from ecosanoid in leucocytes marked cells platelets and macrophages

A

Leukotrienes

50
Q

Insertion of diatomic oxygen at carbon 5 of Arachidonic acid to yield 5 hydro peroxylecosatetrationic acid is aided by

A

5 lipoxygenase

51
Q

Leukotrienes biosynthesis depends solely

A

On the availability of Arachidonic acid which are released from membrane phospholipid

52
Q

The release of Arachidonic acid from membrane phospholipid are aided

A

By action of cystosolic phospholipase A2

53
Q

Which leukotrienes constrict smooth muscle cells

A

Leukotrienes C4

54
Q

Family of tetraenes formed by the combine action of more than one lipoxygenase on Arachidonic acid are

A

Lipoxyn

55
Q

The activity of epoxygenase in the microsomal system yield

A

Epoxide

56
Q

Which prostaglandin are vasoconstrictor of renal and other vascular tissue

A

Prostaglandin F2 alpha

57
Q

Which hormones inhibit lipolysis

A

Insulin

58
Q

Which hormones stimulate lipolysis

A

Epinephrine

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