Metabolism Enzymes Flashcards
1
Q
Inducers
A
rifampcin, ethanol (why upramps acetominphen), tobacco smoke, St. John’s Wort, phenytoin, pherobarbital
2
Q
Inhibitors
A
Grapefruit juice, ketocanazole, fluoxetine, HIV protease, erythromycin, azole fungals
3
Q
Methanol poisoning
A
methanol hydrolyzed by alcohol dehydrogenase to FORMIC acid (metabolite), treat with ethanol (competitive inhibitor) for alcohol dehydrogenase
4
Q
Ethylene glycol
A
ethylene glycol broken down by alcohol dehydrogenase to oxalic acid, treat with fomezipole (inhibiits alc dehydrogenase)