Metabolism Flashcards
Characteristics of the peptide bond
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Covalent bonds
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Hydrogen bonds
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Ionic interactions
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Van der Waals forces
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Hydrophobic interactions
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N linked glycosylation
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Glutamine
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Formation of of gamma-carboxyglutamate
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6 reaction types defining metabolism
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Glycolysis reaction 1
Enzyme: hexokinase
Reactant: glucose
Product: glucose-6-phosphate and a proton
Reaction:
Glycolysis reaction 2
Enzyme: phosphoglucose isomerase
Reactant: glucose-6-phosphate
Product: fructose-6-phosphate
Reaction:
Glycolysis reaction 3
Enzyme: phosphofructokinase
Reactant: fructose-6-phosphate
Product: fructose-1,6-biphosphate
Reaction:
Glycolysis reaction 4
Enzyme: aldolase
Reactant: fructose-1,6-biphosphate
Product: glyceraldehyde-3-phosphate and dihydroxyacetone phosphate
Reaction:
Glycolysis reaction 5
Enzyme: triose phosphate isomerase (TPI)
Reactant: dihydroxyacetone phosphate
Product: glyceraldehyde-3-phosphate
Reaction:
Glycolysis reaction 6
Enzyme: glyceraldehyde 3-phosphate dehydrogenase
Reactant: 2 x glyceraldehyde-3-phosphate
Product: 2 x 1,3-biphosphoglycerate
Reaction:
Glycolysis reaction 7
Enzyme: phosphoglycerate kinase
Reactant: 2 x 1,3-biphosphoglycerate
Product: 2 x 3-phosphoglycerate
Reaction:
Glycolysis reaction 8
Enzyme: phosphoglycerate mutase
Reactant: 2 x 3-phosphoglycerate
Product: 2 x 2-phosphoglycerate
Reaction:
Glycolysis reaction 9
Enzyme: enolase
Reactant: 2 x 2-phosphoglycerate
Product: 2 x phosphoenolpyruvate and 2 x water molecule
Reaction:
Glycolysis reaction 10
Enzyme: pyruvate kinase
Reactant: 2 x phosphoenolpyruvate
Product: 2 x pyruvate
Reaction:
3 possible pathways which the pyruvate molecules can take
- alcoholic fermentation
- generation of lactate
- generation of acetyl CoA
Alcoholic fermentation
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Generation of lactate
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Generation of acetyl CoA
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Pyruvate dehydrogenase complex
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Pyruvate decarboxylase
Function:
Prosthetic group:
Lipoamide reductase-transacetylase
Function:
Prosthetic group:
Dihydrolipoyl dehydrogenase
Function:
Prosthetic group:
LDH
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Creatine phosphate
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Glycerol phosphate shuttle
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Malate-aspartate shuttle
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define coenzyme
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Glucose metabolism in cancer
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