Metabolic syndrome

Question 1

Definition of metabolic syndrome

Answer 1

Abdominal obesity (>40 in, 35 for women)
Hyper triglyceridemia (>150)
low HDL- 
HTN>130/85
impaired fasting flucose- or diabetes

Question 2

Mechanism of the metabolic syndrome

Answer 2

Lots of fat releases Free fatty acids
Lots of VLDL an dlowered HDL- Muscle fat doesnt allow glucose and insulin in

Inflammatory cytokines
Insulin increases sodium resorption –> HTN

2 possible mechonisms of insulin resistance- too much inflammation- receptor activity and post receptor changes

Fatty acid build up

Question 3

Pharmacologic Rx of obesity

Answer 3

Orlistate- inhitibts gastic lipases

Phentermine- sympathomimetic- reduces appetit via hypothalamus

HTN: ACES and ARBS
HMGcoa inhibitors statin / ezetiminde, PCSK9, Hyper TG (i

Metformin