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Frontiers in Biomedicine > Metabolic Syndrome > Flashcards

Metabolic Syndrome Flashcards

1
Q

The hypothesis?

A

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2
Q

Discuss the epidemiology of MS

A

income inequality
activity levels
changes in food

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3
Q

CVD - unestablished risk factors? (4)

A

left ventricular size
fibrinogen
lipids (other than cholesterol)
homocysteine

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4
Q

CVD - established risk factors? (10)

A 
age (2)
gender (2)
family history (1)
genes (1)
cholesterol (1)
alcohol (1)
hypertension (1)
smoking (3)
physical inactivity
stress
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5
Q

Describe the structure of insulin

A

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6
Q

Describe the glucose uptake mechanism of insulin

A

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7
Q

Describe the mechanism of insulin release

A

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8
Q

Actions of insulin

A 
Stimulates:
glucose uptake (GLUT4)
glycogenesis
glyolysis
production of TAGs

Inhibits:
gluconeogenesis
glucogenolysis
proteolysis

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9
Q

Dicuss glucagon and its release mechanism

A

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10
Q

T1DM (4)

A

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11
Q

T2DM definition and phases

A

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12
Q

Lipotoxicity Model (7)

A

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13
Q

Insulin receptor

A

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14
Q

Lipoproteins & related Apos

A

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15
Q

Exogenous pathway

A

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16
Q

Endogenous pathway

A

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17
Q

Reverse cholesterol pathway

A

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18
Q

factors affecting blood cholesterol

A 
diet
exercise
weight
smoking
genes
age
sex (before 55yrs, lower in women)
19
Q

factors affecting blood TAGs

A 
insulin resistance
excess alcohol
hypothyroidism
medications
genes (rare)
20
Q

HDL catabolism

A

-

21
Q

how does hypertension affect CV

A

turbulence and plaques

22
Q

atherosclerosis pathway

A

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23
Q

Population Health 5 Ways

give examples

A 
Health promotion
Regulation of food for quality and safety
Tax to raise prices and modify behaviour
Regulation of advertising
Economic Policy
24
Q

Population Health - solution for Australia?

A

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25
Q

Describe the economic evaluation flow chart

A

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26
Q

Describe cost-effectiveness graph

A

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27
Q

Describe QALY graph

A

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28
Q

Applications of simulation models?

A

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29
Q

Adapting simulation models?

A

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30
Q

Surgical vs medical treatment of obesity?

A

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31
Q

Types of physical activity?

A

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32
Q

Genetics & obesity?

A

2 studies

33
Q

Epigenetics & obesity

A

poland wII

rat study

34
Q

Medical management of obesity?

A

-

35
Q

Failure of diets

A

about ghrelin

36
Q

Obesity pharmacotherapy options?

A

3

37
Q

Phentermine and topiramate side effects

A

-

38
Q

Types of bariatric surgery

A

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39
Q

Managing MS table

A

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Frontiers in Biomedicine (11 decks)

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