Metabolic Diseases Flashcards
What do we NOT advise on nutrition after diabetes is diagnosed?
a. as little as possible of all carbohydrates
b. as many different vegetables as possible
c. avoiding white bread
d. as little fat as possible
e. avoiding simple sugars
a. as little as possible of all carbohydrates
Metabolic syndrome is characterized by:
a. uremia
b. hyperinsulinemia
c. hypoinsulinemia
d. hyperglucagonemia
e. hypoglucagonemia
b. hyperinsulinemia
Chronic hyperglycemia can be caused by:
a. hyperthyroidism
b. Cushing’s disease
c. acromegaly
d. pheochromocytoma
e. all of the above
e. all of the above
The final secretions of the beta cell of the pancreas are:
a. insulin
b. insulin, C-peptide
c. insulin, C-peptide, proinsulin
d. insulin, C-peptide, proinsulin, preproinsulin
e. insulin, C-peptide, proinsulin, preproinsulin, glucose
c. insulin, C-peptide, proinsulin
The recommended diet of a patient with diabetes includes:
a. 45-60% carbohydrates
b. 45-60% protein
c. 45-60% fat
d. lots of fiber
a. 45-60% carbohydrates
d. lots of fiber
Lack of insulin in the body causes
a. lipolysis
b. central lipolysis, peripheral lipogenesis
c. increased gluconeogenesis
d. reduced gluconeogenesis
e. proteolysis
f. increased protein synthesis
a. lipolysis
c. increased gluconeogenesis
e. proteolysis
Hyperglycemia in pregnancy can cause
a. fetal diabetes
b. hypoplasia of pancreatic beta cells
c. fetal anomalies
d. dehydration of the fetus
e. lack of amniotic sac
c. fetal anomalies
Microalbuminuria:
a. It is a specific change in diabetic kidney disease
b. It means increased excretion of albumins in the urine
c. It means reduced excretion of albumins in the urine
d. It means the excretion of small albumins in the urine
e. It is a worse prognostic factor for the progression of renal disease in SB type 1
than in SB type 2
b. It means increased excretion of albumins in the urine
Identify the correct statements
a. Diabetes is an etiologically heterogeneous disease.
b. Diabetes is often asymptomatic.
c. The level of glucose tolerance may vary in patients with impaired glucose
tolerance
All of them
Diabetes occurs more often in the following disease:
a. albinism
b. Cushing’s syndrome
c. nephrotic syndrome
d. sarcoidosis
e. chronic inflammatory bowel disease
b. Cushing’s syndrome
Choose the correct statements:
a. genetic defects in insulin action are an important mechanism of diabetes
b. many people with type 2 diabetes have undiagnosed diabetes
c. In the incidence of type 1 diabetes, Slovenia is at the very top among European
countries
b. many people with type 2 diabetes have undiagnosed diabetes
C-peptide is characterized by:
a. It is secreted from the beta-cells of the pancreas
b. It is formed from a precursor molecule in the bloodstream
c. It is secreted in an equimolar amount as insulin
d. May act as an inhibitor of insulin action
e. The formation depends on the concentration of blood glucose
a. It is secreted from the beta-cells of the pancreas
c. It is secreted in an equimolar amount as insulin
e. The formation depends on the concentration of blood glucose
Secretion of insulin from beta-cells of the pancreas accelerates:
a. glucose
b. fatty acids
c. ketones
d. amino acids
All of them
Glucose stimulates the beta-cell of the pancreas to secrete insulin:
a. through diffusion
b. via active transport
c. via an osmotic gradient
d. via binding to a receptor on the beta cell membrane
e. via binding to the intracellular beta cell receptor
d. via binding to a receptor on the beta cell membrane
The main target tissue for insulin action is:
a. muscle, liver, fat
b. heart, liver
c. heart and brain
d. kidneys
e. erythrocytes
a. muscle, liver, fat
The strongest stimulus for the secretion of insulin from the beta cell of the pancreas is:
a. glucose
b. fatty acids
c. ketones
d. arginine
e. isoleucine
a. glucose
Choose the correct statements about insulin:
a. when it is lacking, catabolism prevails
b. in its absence, anabolism prevails
c. hepatic insulin extraction is greater after feeding
d. hepatic insulin extraction is greater during starvation
a. when it is lacking, catabolism prevails
c. hepatic insulin extraction is greater after feeding
Choose the correct statements about insulin:
a. It is excreted constantly
b. It is excreted after meals
c. The most important effect in the liver is the inhibition of lipolysis
d. The most important effect in the liver is the stimulation of lipolysis
a. It is excreted constantly
c. The most important effect in the liver is the inhibition of lipolysis
Metabolic syndrome includes:
a. impaired glucose tolerance
b. diabetes
c. impaired glucose tolerance, increased blood pressure
d. impaired glucose tolerance, increased blood pressure, waist circumference
e. impaired glucose tolerance, increased blood pressure, waist circumference, visual disturbances,
increased plasma triglycerides
d. impaired glucose tolerance, increased blood pressure, waist circumference
In the diet recommended for patients with diabetes, they represent the largest
share (energy)
a. liquid
b. fats
c. proteins
d. carbohydrates
d. carbohydrates
Are diabetes patients more susceptible to infections?
a. Yes
b. no
a. Yes
Do acute illnesses increase the need for insulin?
a. Yes
b. no
a. Yes
Which patient is more likely to require hospital treatment for a urinary tract
infection?
a. DM type 1
b. DM type 2, which is treated with a maximum dose of oral antihyperglycemic agents
b. DM type 2, which is treated with a maximum dose of oral antihyperglycemic agents
It applies to the diet of a patient with diabetes without chronic complications
a. may contain simple sugars that are added to the mixed meal, but the
maximum allowed amount is 5 g
b. it must not contain simple sugars
c. protein should dominate
d. it is desirable to consume as much fiber as possible
d. it is desirable to consume as much fiber as possible
The most suitable diet for diabetes is:
a. a diet with as few carbohydrates as possible and as much protein as possible
b. a diet with as few carbohydrates and fats as possible and as much protein as possible
c. a diet with predominant components of fruits and vegetables
d. fasting diet
e. a diet based on healthy eating recommendations
e. a diet based on healthy eating recommendations
Circle the correct statement about nutrition in diabetes.
a. Foods containing simple carbohydrates are absolutely forbidden.
b. Carbohydrate foods should be distributed at all daily meals.
c. We avoid foods with carbohydrates.
d. Vitamins and minerals are important energy foods in the diabetes diet.
e. Because of the impact on the complications caused by hyperglycemia, we advise each
patient to supplement with antioxidants and minerals.
b. Carbohydrate foods should be distributed at all daily meals.
Type 1 diabetes is caused by
a. genetically conditioned pathological insulin molecules
b. destruction of beta cells due to autoimmune inflammation
c. destruction of beta cells in acute pancreatitis
d. changes in mitochondrial DNA
e. reduced regenerative abilities of pancreatic beta-cells
b. destruction of beta cells due to autoimmune inflammation
Type 1 diabetes is characterized by
a. when the disease is detected, antibodies to antigens are present, which are components of
the membrane and cytoplasm of the beta cell
b. typically, the pathogenetic process lasts a maximum of several weeks before the appearance of clinical
signs
c. clinical manifestation of the disease with mild and uncharacteristic symptoms
d. when the disease is discovered, ketoacidosis may be present
a. when the disease is detected, antibodies to antigens are present, which are components of
the membrane and cytoplasm of the beta cell
d. when the disease is discovered, ketoacidosis may be present
Type 1 diabetes is characterized by:
a. decreased function of the beta cells of the islets of Langerhans
b. increased insulin resistance
c. is more common than type 2 diabetes
d. in order to make a diagnosis, we perform tests on the most common antigens and
antibodies involved
a. decreased function of the beta cells of the islets of Langerhans
Type 1 diabetes is characterized by:
a. great kinship tendency
b. autoimmune features
c. possible lifelong insulin dependence
d. complete concordance of monozygotic twins
b. autoimmune features
c. possible lifelong insulin dependence
Type 1 diabetes applies to:
a. we see a seasonal variation in occurrence
b. we see a steady rise in incidence
c. a screening for it would be useful, but at the moment the health fund does not have
enough money
d. the peak of occurrence is in early childhood, when respiratory infections are also very common
a. we see a seasonal variation in occurrence
b. we see a steady rise in incidence
Type 1 diabetes is characterized by:
a. is predominantly immune-induced
b. is predominantly idiopathic
c. when the disease manifested, almost 50% of the beta cells died
d. three-quarters of the beta cells have died at the onset of the disease
e. when the disease manifests, practically all beta cells are destroyed
a. is predominantly immune-induced
d. three-quarters of the beta cells have died at the onset of the disease
In type 1 diabetes:
a. in addition to the islets of Langerhans, the exocrine pancreatic function is
often affected
b. apart from the islets of Langerhans, there is no characteristic impairment of the exocrine
pancreatic function
c. glucagon secretion is often affected in addition to the islets of Langerhans
d. glucagon secretion is not affected
e. the secretion of somatostatin is often affected due to the cytotoxic tissue
response
b. apart from the islets of Langerhans, there is no characteristic impairment of the exocrine
pancreatic function
d. glucagon secretion is not affected
Type 1 diabetes is characterized by an antibody:
a. ACE
b. MPO
c. NASTY
d. Ttg
e. EMA
c. NASTY
Newly diagnosed type 1 diabetes is clinically expressed by:
a. polyuria
b. oliguria
c. nocturia
d. weight reduction
e. weight gain
a. polyuria
c. nocturia
d. weight reduction
In type 2 diabetes we find:
a. albuminuria
b. hematuria
c. hypercalcemia
a. albuminuria
Type 2 diabetes is characterized by:
a. Insulin secretion is insufficient in every phase of the disease
b. Insulin secretion is sufficient in the initial stages, but then it decreases and becomes
insufficient
c. Insulin secretion is sufficient in all phases of the disease, hyperglycemia is the
result of insulin resistance
d. Insulin secretion is sufficient in all stages of the disease, hyperglycemia is the result of
uncontrolled hepatic gluconeogenesis
e. Insulin secretion is sufficient, but hyperglycemia is the result of both uncontrolled
hepatic gluconeogenesis and reduced responsiveness of fat and muscle to preexisting insulin
a. Insulin secretion is insufficient in every phase of the disease
What is specific about DM 2:
a. US small kidney
b. nephrotic syndrome
c. increased albuminuria
c. increased albuminuria
Untreated or newly diagnosed type 2 diabetes is clinically expressed by:
a. Polyuria
b. Oliguria
c. Nocturia
d. By reducing body weight
e. By increasing body weight
a. Polyuria
c. Nocturia
d. By reducing body weight
Patients with type 2 diabetes usually have the following characteristics:
a. under 40 years old
b. overweight
c. when the disease occurs, insulin secretion is insufficient
d. at the onset of the disease, insulin secretion is still present
e. family tendency
b. overweight
c. when the disease occurs, insulin secretion is insufficient
d. at the onset of the disease, insulin secretion is still present
e. family tendency
The basis of successful treatment of type 2 diabetes is
a. metformin
b. healthy balanced diet
c. insulin replacement
d. adequate hydration
e. combination therapy with metformin and a sulfonylurea
b. healthy balanced diet
Type 2 diabetes is characterized by:
a. tends to metabolic deterioration despite treatment
b. familial occurrence is not pronounced
c. when it appears, it manifests itself with a turbulent clinical picture
d. insulin secretion is not impaired
e. often occurs after frequent pancreatitis
a. tends to metabolic deterioration despite treatment
Type 2 diabetes applies to:
a. the incidence of occurrence is highest after the age of 65
b. the incidence is decreasing due to good prevention
c. pancreatic beta cell dysfunction has a characteristic tendency to worsen
d. an important risk factor for its occurrence is obesity
c. pancreatic beta cell dysfunction has a characteristic tendency to worsen
d. an important risk factor for its occurrence is obesity
Type 2 diabetes is characterized by:
a. the onset of the disease is sudden
b. etiopathogenesis is similar to impaired glucose tolerance
c. etiopathogenesis is similar to that of borderline basal glycemia
d. when diabetes develops, hyperinsulinemia may still be present
b. etiopathogenesis is similar to impaired glucose tolerance
d. when diabetes develops, hyperinsulinemia may still be present
Type 2 diabetes applies to:
a. it is a clinically homogeneous disease
b. it is a clinically heterogeneous disease
c. insulin responsiveness is impaired at both the postreceptor and prereceptor
levels
d. there is also always a defect in insulin secretion
b. it is a clinically heterogeneous disease
Type 2 diabetes applies to:
a. Slovenia has a lower disability than neighboring countries
b. Slovenia has a similar vulnerability to neighboring countries
c. It is more common in women
d. When discovered, it is mostly symptomatic
b. Slovenia has a similar vulnerability to neighboring countries
c. It is more common in women
MODY is:
a. form of type 1 diabetes
b. form of type 2 diabetes
c. a more severe course of diabetes is typical
d. a milder course of diabetes is typical
b. form of type 2 diabetes
d. a milder course of diabetes is typical
Type 2 diabetes:
a. is caused by a reduced ability to secrete insulin
b. upon discovery, all patients have symptomatic hyperglycemia
c. upon discovery, signs of involvement of the large vessels can be identified
d. upon discovery, signs of microangiopathy can be identified
a. is caused by a reduced ability to secrete insulin
c. upon discovery, signs of involvement of the large vessels can be identified
d. upon discovery, signs of microangiopathy can be identified
Type 2 diabetes is characterized by:
a. insulin secretion in the basal state is somewhat weaker in obese people
b. insulin secretion in the basal state is stronger in obese people
c. with the increase in glucose concentration after exercise, the secretion of insulin from
the pancreas increases proportionally
d. as the concentration of glucose increases after exercise, the secretion of insulin from
the pancreas decreases proportionally
b. insulin secretion in the basal state is stronger in obese people
c. with the increase in glucose concentration after exercise, the secretion of insulin from
the pancreas increases proportionally
Type 2 diabetes
a. there is no beta cell damage, but the primary pathogenesis is increased tissue resistance
b. mostly in obese people
c. can’t get skinny people
a. there is no beta cell damage, but the primary pathogenesis is increased tissue resistance
b. mostly in obese people
The drug of choice for the initiation of treatment for type 2 diabetes is
a. metformin
b. insulin secretagogue
c. a drug that acts on the incretin system
d. insulin
a. metformin
For most patients with type 2 diabetes, the target HbA1c is
a. below 8.0%
b. below 6.5%
c. below 7.5%
d. below 7.0%
d. below 7.0%
Hyperglycemia in pregnancy can cause:
a. fetal diabetes
b. hypoplasia of pancreatic beta cells
c. fetal anomalies
d. dehydration of the fetus
e. lack of amniotic sac
c. fetal anomalies
Pregnancy DM is usually treated with:
a. diet and, if necessary, insulin
b. diet and, if necessary, with metformin
c. diet and, if necessary, herbal teas
d. only with a diet, because as a rule it is mild
e. diet and, if necessary, a sulfonylurea
a. diet and, if necessary, insulin
Choose the correct statements.
a. Pre-existing diabetic retinopathy and diabetic nephropathy can be
expected to worsen during pregnancy
b. Diabetes may reoccur during pregnancy, but glucose tolerance
normalizes after delivery.
c. Women who have had gestational diabetes have a high risk of developing type
1 diabetes.
a. Pre-existing diabetic retinopathy and diabetic nephropathy can be
expected to worsen during pregnancy
b. Diabetes may reoccur during pregnancy, but glucose tolerance
normalizes after delivery.
Circle the correct statements:
a. Diabetic retinopathy can worsen during pregnancy.
b. Diabetic nephropathy can worsen during pregnancy.
c. Hyperglycemia in pregnancy can cause diabetic fetopathy.
d. Hyperglycemia causes a higher number of late intrauterine deaths.
All of them
Circle the correct answers:
a. gestational diabetes is a risk factor for the later development of type 2
diabetes in the mother
b. diabetes in pregnancy is a risk factor for the later development of type 2
diabetes in the child
c. stricter control of the fetus in a mother with gestational diabetes is necessary
especially in the first trimester of pregnancy
d. untreated or poorly treated diabetes in pregnancy causes microsomia.
a. gestational diabetes is a risk factor for the later development of type 2
diabetes in the mother
b. diabetes in pregnancy is a risk factor for the later development of type 2
diabetes in the child
Circle the correct answers regarding diabetes in pregnancy.
a. Glucose passes into the placenta by active transport.
b. Maternal hyperglycemia causes pancreatic B cell hyperplasia in the child
and may cause hypoglycemia in the newborn.
c. Both hyperglycemia and hypoglycemia in early pregnancy are teratogenic.
b. Maternal hyperglycemia causes pancreatic B cell hyperplasia in the child
and may cause hypoglycemia in the newborn.
Why is diabetes in pregnancy a threat to the child?
a. due to the presence of glycemia
b. due to a higher concentration of insulin in the mother
c. due to a lower concentration of growth hormone in the mother
a. due to the presence of glycemia
Which pregnant women have a higher risk of developing malformations in the child?
a. those with frequent hypoglycemia
b. those with high HbA1c
c. those with a high daily dose of insulin
b. those with high HbA1c
When do malformations occur during embryonic development?
a. in the first 8 weeks
b. between the 20th and 30th week
c. between 10 and 15 weeks
a. in the first 8 weeks
Does pregnancy increase the risk of hypoglycemia in the first few weeks of pregnancy?
a. Yes
b. no
a. Yes
Does pregnancy increase the risk of progression of microvascular chronic complications of
DM?
a. Yes
b. no
a. Yes
Why is it necessary to add folic acid before and during pregnancy?
a. to prevent hypertension in pregnancy
b. to prevent fetal growth retardation
c. to prevent spina bifida
c. to prevent spina bifida
The way we look for pregnant women with pathological glycemia:
a. screening
a. screening
Hyperglycemia in the mother can cause hypoglycemia/hyperglicemia in a newborn.
hypoglicemia
The most characteristic malformation in mothers with DM type 1:
a. caudal regression.
a. caudal regression.
Method of delivery, which is more common in patients with hyperglycemia in pregnancy:
a. Caesarean section.
a. Caesarean section.
Part of the body of the fetus, the extent of which most reflects the harmful consequences of hyperglycemia:
a.belly.
a.belly.
The most common cause of death of a pregnant woman with long-lasting diabetes is
-acute
myocardial infarction.
-acute
myocardial infarction.
Which medicinesthey are not insulin secretagogues?
a. sulfonylurea
b. meglitinides
c. metformin
d. DPP-4 inhibitors
e. SGLT-2 inhibitors
f. acarbose
g. thiazolidinedione
c. metformin
d. DPP-4 inhibitors
e. SGLT-2 inhibitors
f. acarbose
g. thiazolidinedione
When is metformin contraindicated?
a. after an acute heart attack
b. low oGF values
c. high oGF values
d. in obese people
e. in skinny people people
a. after an acute heart attack
b. low oGF values
Correct statement about metformin:
a. first choice for type 2 diabetes
b. has severe side effects, therefore very rarely indicated
c. it is used with benefit in patients with type 1 diabetes
d. GIT side effects manifest as ulcer disease
a. first choice for type 2 diabetes
How do we regulate glycemia in a person who does not eat or drink per os:
a. rapid-acting insulin sc
b. short-acting insulin is administered via an insulin pump
c. IV insulin boluses are administered.
b. short-acting insulin is administered via an insulin pump
Which of the following should we consider when choosing antidiabetic therapy?
a. The effectiveness of the drug
b. Risk of hypoglycemia
c. Body weight
d. Side effects of the drug
e. The price of the drug
All of them
Medicines from the group of sulfonylureas can be combined with:
a. Insuline
b. DPP-4 inhibitors
c. Metformin
d. To all of the above
e. None of the above
d. To all of the above
When introducing insulin therapy, we calculate the approximate initial daily dose based
on:
a. BMI
b. Fasting and postprandial plasma glucose concentrations
c. Body weight
d. Carbohydrate content in food
e. Prior oral therapies
c. Body weight
Which of the listed insulin preparations doesn’t belongs to insulin analogues?
a. Lispro
b. Apidra
c. NPH
d. Aspart
e. Glargine
c. NPH
The most common side effect of insulin treatment is
a. local lipodystrophy
b. hypersensitivity reaction
c. hypoglycemia
d. insulin edema
e. hirsutism
c. hypoglycemia
Stimulators of insulin secretion are the following drugs:
a. metformin
b. sulfonylurea
c. acarbose
d. methylprednisolone
b. sulfonylurea