Metabolic and Endocrine

Question 1

Metabolic & Endocrine: Hormone Replacement Agents

Answer 1

• Action
  
  • restore normal endocrine function when endogenous production of a particular hormone is deficient or absent
• indications
  
  • decrese in endogenous hormone secretion
• Side Effects
  
  • vary by exogenous or synthetic hormone therapy used for treatment
• PT
  
  • be aware of signs of hormones deficit and hormone therapy
• Examples
  
  • see specific categories

Question 2

Metabolic & Endocrine: Hyperfunction Agents

Answer 2

• Actions
  
  • manage hyperactive endocrine fxn to allow inhibition of hormone fxn via neg feedback loops or hormone antagonists
• Indications
  
  • hyperactive or excessive endocrine function
• Side Effects
  
  • vary by hormone
• PT
  
  • be aware of side effects and signs of hyperfunction
• Examples
  
  • see specific categories

Question 3

Metabolic & Endocrine: Bone Mineral Regulating Agents

Answer 3

• Actions
  
  • attempt to enhance and max bone mass along w/ preventing bone loss or rate of bone reabsorption
• Indications
  
  • Paget’s dx, osteoporosis, hyperparathyroidism, rickets, hypoparathyroidism, osteo malacia
• Side Effects
  
  • agent dependent, GI distress, dyspepsia, dysphagia, anorexia, bone pain, arrhythmia
• PT
  
  • pts w/ deficit are at risk for fracture and side effects from drug therapy. attempt WB activities to promote bone health
• Examples
  
  • Estrogens: Premarin
  • calcium and vit D: calc carbonate (tums), calderol (calcifediol),
  • biphosphonates: fosamax (alendronate sodium), Boniva (ibandronate)
  • calcitonin: cibacalcin (human calcitonin)