Metab Integration MCQ

Question 1

When insulin binds to the insulin receptor, all of the following will be phosphorylated except: 
	A. Insulin receptor 
	B. Insulin receptor substrate 
	C. PI3 kinase 
	D. Akt

Answer 1

C. PI3 kinase

PI3 kinase is activated, but not via phosphorylation

Question 2

Binding of glucagon to its receptor in the liver will lead to activation of all of the following except: 
	A. G-protein 
	B. Adenylate cyclase 
	C. Protein kinase B 
	D. Glycogen phosphorylase

Answer 2

C. Protein kinase B

Question 3

Binding of epinephrine to the alpha-adrenergic receptor will lead to all of the following except
A. Increase cellular IP3
B. Increase formation of diacylglycerol
C. Activate phospholipase C
D. Cause release of Ca2+ from ER
E. Increase formation of PI3,4,5-triphosphate

Answer 3

E. Increase formation of PI3,4,5-triphosphate

Question 4

All of the following are examples of second messengers except 
	A. cAMP 
	B. AMP 
	C. Inositol triphosphate (IP3) 
D. diacylglycerol

Answer 4

B. AMP

Question 5

Which of the following is not activated by insulin in the liver during the well-fed state? 
	A. Glycolysis 
	B. Glycogenesis 
	C. Fatty acid synthesis 
	D. Protein synthesis 
E. Hexose monophosphate shunt

Answer 5

E. Hexose monophosphate shunt

Question 6

During starvation, the liver is able to synthesise and export 
	A. Acetyl coA and glucose 
	B. Alanine and glucose 
	C. Ketone bodies and glucose 
	D. Fatty acids and glucose

Answer 6

C. Ketone bodies and glucose

Question 7

All of the following are true of prolonged starvation except
A. Liver glycogen is depleted
B. The brain is able of use ketone bodies for ATP production
C. Urea production increases proportionally w the length of starvation
D. Liver carries out gluconeogenesis

Answer 7

C. Urea production increases proportionally w the length of starvation

Question 8

Which one of the following is NOT responsible for lowering blood glucose after a meal? 
	A. Liver 
	B. Brain 
	C. Skeletal muscles 
	D. Adipose tissues

Answer 8

B. Brain

Question 9

Obesity is considered as being continually in the well-fed state. In such a situation, which one of the following is likely to stop occurring in the liver? 
	A. Glycogen synthesis 
	B. Glycolysis 
	C. Fatty acid synthesis 
	D. TCA cycle

Answer 9

A. Glycogen synthesis
Glycolysis and TCA cycle will continue taking place cause the obese person still needs to generate energy. Glycogen synthesis wont be taking place, not using up glycogen stores.

Question 10

Which one of the following is the main purpose of the CORI cycle?
A. To help maintain blood glucose via gluconeogenesis
B. To metabolise lactate that is produced in non-hepatic tissues
C. To provide liver with a source of pyruvate

Answer 10

B. To metabolise lactate that is produced in non-hepatic tissues

Question 11

Which of the following occurs after an insulin injection?
A. Increased lipolysis of fat cells
B. Increased gluconeogenesis in the liver
C. Increased levels of insulin C-peptide
D. Increased GLUT4 transport of glucose

Answer 11

D. Increased GLUT4 transport of glucose

Synthetic insulin has disulfide bond but does not have C-peptide

Question 12

Which of the following biochemical changes is likely to occur in uncontrolled T1DM?
A. Decreased serum osmolality
B. Increased activity of lipoprotein lipase
C. Increased levels of beta-hydroxybutyrate
D. Increased blood pH levels

Answer 12

C. Increased levels of beta-hydroxybutyrate

Question 13

What is the major risk of giving insulin first before fluid replacement to a patient with hyperosmolar non-ketotic syndrome?
A. The patient will become hypoglycemic
B. The patient will become hyperkalemic
C. The patient’s BP may drop suddenly

Answer 13

C. The patient’s BP may drop suddenly

Question 14

Which signalling pathway in the hypothalamus is most likely disrupted from circulating fatty acids and cytokines in obese patients? 
	A. GLP-1
	B. CCK
	C. PYY
	D. Insulin

Answer 14

D. insulin

Question 15

Which of the following changes would most likely be observed following weight loss? 
	A. Decreased ghrelin 
	B. Increased insulin 
	C. Decreased leptin 
	D. Increased PYY

Answer 15

C. Decreased leptin