Messadi 2.23.15 - Ulcerative and other Immune Mediated Diseases Part II Flashcards
what are the 3 most common diseases of the mouth and in waht order
- caries
- periodontal disease
- RAS
aphthous ulcer is well understood
and is what specific agent cauases it?
false, poorly unerstoond
NO specific infectious agent
shallow
painful red lesion
with white base
aphthous ulcer
do you rarely or often biopsy alphthous ulcer
rarely biopsy
PBL of althous ulcer have an
decrese in :______
increase in: ______ _____ ____
decrease in CD4/CD8 ratio
increase in TNF - alpha, IL - 2 and IL - 6
genetic predisposition with RAS assoicated with 4 HLA [human leukocyte antigen] ?
B51
A2
B12
Dr5
___ and ___ exposure do NOT increase RAS risk
but may actually DECREASE the risk of aphthous ulcers
smoking
nicotine
_____ are associated with menstrual cycle,
with outbreaks most commonly occuring during _____ or
before _____
RAU
during ovulation
before menstruation
TF
diminished incidence of RAU during pregnancy has been reported
true
TF
RAS is more prone to women especially during the menstrual cycle
true
dietary risk factors for aphthous ulcer:
Fe
folic acid
Zn
vitamine B, 1, 6, 12
TF
food sensitivities can be a triggering factor for RAS, especially tomatoe
true
the foaming effect of _____ toothpaste can be a risk factor to develop RAS
SLS
Sodium lauryl sulfate
4 ssytemic diseases asscoaited with RAS
behcet’s disease
immune related coniditons
chronic GI Absorption diseases
dermatologic disorder
waht are the 3 immne related condiitons
cyclic neturopenia
agranulocytosis
immunodeficiency [HIV} disease
3 syndromes associated with RAS
PFAPA - periodic fever, adenitis, pharyngitis, and aphthous ucler
magic - mouth nd genital ulcers, with inflamed cartilage
sweet’s
aphthous ulcer occurs more on ____ mucosa and cold sore [herpes] happens more on ____ mucosa
nonkeratinized mucosa - aphthous ulcer
keratinized mucosa -> cold sore
TF
when we have multiple lesions have to rule out systemic disease
true
red with slight elevation
shallow ucler
round and oval shape
no more than 1/4 in diameter
center covered by lososely attached white or grayish mem
edges are normal [non-jagged]
aphthous ucler
which ulcer type looks most like herpes
herpetiform ulcer
which of the 3 ulcers is the most common
minor aphthous ulcer
TF
minor aphthous ucler will spont heal after 10 days without treatment
also does not have scarring
true
true
waht is another name ofr major aphthae
sutton disease
what are 3 differences bt minor and major aphtous ucler
major:
scarring
heals 10 - 30 days
GREATER than 10 mm in diameter
TF
there are no lab diagnostic test for aphthous ucler
true
so instead we diagnosis by exclusion OF 2ndary SYSTEMIC DISEASES
TF
therare 6 ulcer characteristics and based on their score dictates therapy
true
size
of ulcers per episode
duration [#of weeks]
ulcer free period
site [keratinizied or non-keratinizied]
pain
TF
histology doesnt give us much about aphthous ucler when we do NOT suspect systemic infection
true
just shows us as non-specific ulceratin
Preulcer/ prodrmal stage has ___ cells and __
later stage has _____ and ____
last stage? ___
t4 and lymphocytes
T8 and cytotoxin cells
neutrophils, macrophage,s plasma
with mild type A aphtous ulcer we use topical corticosteroids agents like ___ and ____
clobetasol
steroid compunded in Orabase
EM Major is also called
stevens - johnson syntrome
TEN
toxic epidermal necrolysis is always triggered by _____ ___
drug reaction
a subtype of erythema multiforme
diffuse sloughing of the skin and mucosa
[looks like 3rd degree burns]
TEN
Chronic ulcerative stomatitis is treated with Plaquinil
what other disease is treated with this
lupus
[most common autoimmune disease]
what are other names of geographic tonuge
erythema migrans
and
______
orofacial granulomatosis is due to an allergic reaction
true
for wegnerners granulomatosis you have to do a blood test to diagnose the disease
TF
true
what is a neumonic for wegneers granulomatosis
strawberry gingivitis
RAS is most likely caused by
- bac infection
- viral infection
- immune mediated response
- idiopathic
immune mediated response
bc T and B cells
smoking will enhance RAS formation
TF
false
will actually protect your mucosa from RAS
behcet disease is found in
colon
kidney
skin
liver
kidney
genitals
eye
steven johnson is a type of whic disease
erythema multiforme
behcet disease
RAS
wegner granulomatosis
erythema multiform
treatment of erythema multiforme include
corticosterioids
non treatmtmet they normally resolve on their own
systemic antiboides
surgery is needed to remove infection
corticoidsterioids
aphthous major is the most coomon form of apthous ucler
false
minor is the most common form
some known causes of apthous ulcersare
allergy to certain food
herpes virus
nutritional definicies vitamin B12 folic acid iron
A and C
all the above
A and C
the skin lesions in EM are described as
patch
nodule
bull’s eye
saucer
bull’s eye
delayed type hypersensitivitiy reaction is more common in oral mucosa then skin
TF
false
oral mucosa is less susceptible beucase the langerhan cells, saliva,
