mesothelioma

Question 1

early stage disease

Answer 1

multi-modality therapy.

Question 2

advanced disease

Answer 2

cisplatin/pemetrexed is only thing to improve survival

Question 3

smoking association

Answer 3

NOT

Question 4

epi of mesothelioma

Answer 4

simian 40 virus, thorocast, RT, asbestos

Question 5

diagnosis of mesothelioma

Answer 5

PAS stain negative (positive for aden), IHC TTF=1-, CEA-, CD15-, calretinin+, WT1+, vimentin+

Question 6

sarcomatoid/mixed mesothelioma

Answer 6

worse prognosis

Question 7

workup of mesothelioma

Answer 7

TTE to look at heart, MRI to look at diaphragm, chest CT, PET

Question 8

treatment of mesothelioma

Answer 8

extrapleural pneumonectomy + 6 cycles cis/pem –> RT

Question 9

chemo for mesothelioma

Answer 9

pem, gem, dox, cisplatin

Question 10

standard chemo for mesothelioma

Answer 10

cis/pem

Question 11

thymoma presentation

Answer 11

incidental mass, cough, or MG

Question 12

thymoma treatment

Answer 12

surgery, RT if positive margin, check aACR level before surgery

Question 13

chemo for thymoma

Answer 13

anhtracycline based (cis/doxorubicin/cyclophos), alternative etop/ifos/cis

Question 14

thymic carcinoma chemo of choice

Answer 14

carbo/taxol