Mercier BUGs + DRUGs

Question 1

empty card

Answer 1

empty card

Question 2

What drugs DOES NOT cover S. Aureus MSSA

Answer 2

1. PNC G and V (natural)
2. Ampcillin and Amoxicillin ALONE (animopenicillin)
3. 3rd gen cephalosporin –> Ceftazidime
4. Monobactam –> Aztreonam
5. Vancomycin PO (this is only use to treat C.Diff)
6. Gentamicin (animoglycoside) . . . good in vitro but we cant use in practice due to rapid resistance selection !!!
7. Fluoroquinolone –> Ciprofloxacin
8. Nitroimidazole–> Metronidazole (Flagy)

Question 3

What drugs WILL COVER S. Aureus MRSA?

Answer 3

1. 5th Gen Cephalosporin –> Ceftaroline (most gram - coverage)
2. Vancomycin IV
3. All Lipoglycopeptides and lipopeptide (daptomycin)
4. Lincosamides –> Clindamycin
5. Oxazolidinones –> Linezolid/ Tedizolid
6. Tetracycline –> Doxycycline
7. Antifolates –> Trimethoprim/ Sulfa

Question 4

“Most” drugs will cover S. pneumoniae (gram +). . . but which drugs WON’T ???

Answer 4

1. 3rg Gen cephalosporin -> Ceftazidime (only for P. Aeruginosa)
2. Monobactam -> Aztreonam (only for P. Aeruginosa)
3. Vancomycin PO (only for C. Diff)
4. Macrolides are questionable !
5. Gentamicin (animoglycoside)
6. Fluoroquinolone –> only Cipro wont cover (only for atypicals and P. Aeruginosa)

Question 5

Anaerobes . . . Drugs that Cover C. diff? B. Fragilis?

Answer 5

C. Diff –> ONLY VANCOMYCIN ORAL

B. Fragilis –>

1. amp/sulb and amox/clav (animopnc combo!)
2. Pip + tazobactam
3. 2nd gen cephalosporins ( cefoxitin and cefotentan)
4. All Carbapenems
5. Lincosamides–> Clindamycin
6. Fluoroquinolone –> Moxifloxacin only

Question 6

Most Drugs will NOT cover Pseudo. Aeruginosa . . . WHAT DRUGS WILL COVER IT?

Answer 6

1. Pip+tazobactam
2. 3rd gen cephalosporins (ceftazidime only) and 4th gen cephalosporin (cefepime)
3. Monobactam (Azteronam)
4. Carbapenems ( BUT NOT IVANZ or ERTAPENEM)
5. Gentamicin (animoglycoside)
6. Fluoroquinolone ( only cipro and levo only)

Question 7

Most Drugs will NOT cover ATYPICALs . . . WHAT DRUGS WILL COVER IT?

Answer 7

1. Macrolides (clarithromycin and Azithromycin)
2. Tetracycline (Doxycycline)
3. All Fluoroquinolones (Cipro, Levo. Moxi)