Mercedes 80s Flashcards
If the rib cage is totally immobile, how is inspiration possible?
by diaphragmatic breathing (diaphragm does not lift the rib cage)
Muscles of inspiration when contracted increase or decrease thoracic cage volume? Muscles of expiration?
inspiration = increase expiration = decreases
What are the muscles associated with inspiration?
- external intercostals
- levator costarum
- sternocleidomastoid
- serratus ant.
- scaleni
- serratus post. sup.
What are the muscles associated with expiration?
- rectus abdominus
- external and internal obliques
- transverse abdomens (role in low back pain)
- internal intercostals
- serratus post. inf.
- transversus thoracis
- pyramidal
This describes what stage of breathing?
alveolar P > atmospheric P > pleural P
during expiration
This describes what stage of breathing?
alveolar P = atmospheric P > pleural P
end of expiration/inspiration
This describes what stage of breathing?
atmospheric P > alveolar P > pleural P
during inspiration
The measurement of the recoil tendency of the lung is best associated with what specific type of pressure?
Transpulmonary pressure
The following describes what specific type of pressure?
• difference between alveolar P & pleural P
• measure of the recoil tendency of the lung
• peaks at the end of inspiration
Transpulmonary pressure
The following describes what specific type of pressure?
• negative pressure between parietal and visceral pleura that keeps lung inflated against chest wall
• varies between -5 and -7.5 cmH2O (inspiration to expiration
Pleural pressure
The following describes what specific type of pressure?
• subatmospheric during inspiration
• supra-atmospheric during expiration
Alveolar pressure
If the visceral pleural erodes and allows a region of the alveolar
space to communicate with the pleural space, what would happen to the functional residual capacity?
FRC would decrease
What else would cause a decrease in the FRC?
puncture of parietal pleura
At the end of normal expiration or with flaccid paralysis what does the volume of the lungs equal?
Functional Residual Capacity
At the onset of inspiration the pleural pressure changes at faster rate than lung volume is referred as what?
”hysteresis”
What is easier to inflate and why…air-filled lung or saline-filled lung?
Saline-filled lung because surface tension forces have been eliminate
What are the 3 major functions of surfactant
- helps stabilize alveolar size
- reduces surface tension*
- offsets collapse pressure as radius decrease
What type of cells is surfactant produced by?
Produced by type II alveolar epithelial cells
When histamine binds to H1 receptors how does it affect smooth muscle of the airway?
constriction
When histamine binds to H2 receptors how does it affect smooth muscle of the airway?
dilation
When histamine binds to prostaglandins E series how does it affect smooth muscle of the airway?
dilation
When histamine binds to prostaglandins F series how does it affect smooth muscle of the airway?
constriction
What equation to determine FRC?
FRC= ([He]i/[He]f-1) Vi
What equation is used to determine Total Lung Capacity (TLC)?
TLC = TV+IRV+FRC
Which volumes or capacities CANNOT be determined with basic spirometry?
RV, FRC, TLC
What 3 values are decreased with restrictive lung conditions?
- VC (vital capacity)
- IRV (inspiration reserve volume)
- IC (inspiration capacity)
Most of the recoil tendency of the lung is due to what?
2/3 - surface tension forces
1/3 - elastic connective tissue
Alveolar volume = ?
FRC - dead space
What are the 6 pathophysiologic consequences of hyperventilation?
- SV and CO decreased
- Coronary blood flow decreased
- Repolarization of heart impaired
- Oxyhemoglobin affinity increased
- Cerebral blood flow decreased
- Skeletal muscle spasm and tetany
- Serum potassium decreased
What is the major effect of sympathetic stimulation on airway smooth muscle?
dilate, most of the effect is indirect via blood borne
What is the parasympathetic effect on the airway?
constriction using muscarinic receptors
Why is the left ventricular output slightly higher than the right ventricular output?
some bronchial artery blood drains into the pulmonary veins
Which of the following has the greatest effect on constriction of the pre-capillary resistance vessels in the lung?
low alveolar oxygen (want to bypass regions with low alveolar O2)