Mental Health Flashcards
Monoamine Oxidase Inhibitors
Tryanylcypromine, phenelzine, moclobemide (reversible), and rasagiline
Used for atypical depression
SE’s of MAO-I’s
HTN with tyramine containing foods eg. Cheese, marmite, pickled herring etc.
Anticholinergic
Lithium Monitoring
Check lithium levels 12 hour post dose
After starting, check weekly until stable (resume weekly if dose changes- measure after 1 week)
When stable, every 3 months
Thyroid and renal function checked the every 6 months
Check for pregnancy
NB- give patient an info book, alert card, and record book, check levels during acute illness (dehydration can increase level)
Clozapine use
Treatment resistant schizophrenia/ schizophrenia not managed on 2 or more antipsychotic drugs for at least 6-8 weeks
NB- If clozapine doses are missed for more than 48 hours the dose will need to be restarted again slowly
Clozapine SE’s
Agranulocytosis and neutropenia
Reduced seizure threshold
Constipation
Myocarditis
Hypersalivation
Weight gain and increased apetite
EPSE’s eg, Parkinsonism
Clozapine monitoring
Initial weekly FBC UE LFT for 18 weeks, then 2 weekly for a year, then monthly
Baseline ECG
lipids weight etc.
Antipsychotics monitoring
FBC UE LFT- start and annually
Lipids & weight- start, 3 months and annually
BM & prolactin- start, 6 months and annually (patients can present with polyuria and polydipsia, as antipsychotics can dysregulate glucose)
BP- start and during dose titration
ECG- baseline
CV risk- annually
NB- check not pregnant first
SSRI Interactions
NSAIDs- give PPI
Warfarin/ heparin- consider mirtazapine
Triptan and MAO-I: risk of serotonin syndrome
Tramadol- Serotonin syndrome
Citalopram and QT Interval
Citalopram and escitalopram are associated with dose-dependent QT interval prolongation
Shouldn’t be combined with drugs that do the same
NB- citalopram can also cause torsades de pointes
Drugs that lengthen the QT Interval
Amiodarone
Chlorpromazine
Citalopram/escitalopram
Clarithromycin/erythromycin
Flecanide
Haloperidol
Lithium
Methadone
Ondansetron
Risperidone
Venlafaxine
Atypical vs typical antipsychotics
Atypical are used now due to reduced incidence if EP SE’s eg. Parkinsonism, dyskinesia etc.
They still have SE’s though that the old typical drugs had eg. Galactorrhoea, weight gain, anti cholinergic etc.
Typical antipsychotics
Haloperidol
Chlopromazine
Atypical antipsychotics
Clozapine
Olanzapine
Aripiprazole
Risperidone
Quetiapine
Depression Investigations
FBC, UE, LFT, TFT, B12 and folate, HbA1c, cap glucose
NB- pregnancy test/ BMI/ lipids/ ECG (citalopram, escitalopram, amitriptyline) etc.
Depression Management
Refer to talking therapy (CBT), time off work, lifestyle changes
Moderate-severe: SSRI (if doesn’t work, add another one)
Psychiatry referral: SNRI (after 2 SSRI’s)
When to refer a depressed patient to secondary service (psychiatry)
Treatment has failed (non-response to two treatments)
Significant risk of suicide (harm to others/ severe self-neglect)
Psychotic symptoms
Bipolar affective disorder suspected
Child or adolescent presenting with major depression
Depression relapse prevention
First episode (without risk factors (see when to refer..): 6-9 months after remission (consider 1 year if risks)
High risk patients (>5 episodes or >2 in last few years): 2 years, consider life-long
Assess a patient’s cognition
AMT10
AMT10
Year
Time
Place
Age
DOB
20-1
WW1
Monarch
2 People
Address (1 min and 5 min)
Assess a delirious patient
4AT
4AT
Alertness- 4 if abnormal
AMT4 (Age, DOB, location, year)- 2 if 2 or more mistakes
Attention (Dec-Jan)- <7 (1), untestable (2)
Acute change/ fluctuating- 4
AMT 10 Outcome
> 6 normal
4-6 moderate impairment
<3 severe impairment
4AT Outcome
> 4 high chance of delirium
Delusions of grandeur
Special powers or importance
Ideas of reference
Normal events are of special importance to the patient (eg. News reporter)
Nihilistic delusions
They believe they are dead, decomposed, no organs, not human etc.
Paranoid delusions
Exaggerated distrust of others and suspicious of motives
Delusions of Erotomania
Other individuals are in love with them
Persecutory delusions
Patient insists they are being cheated on, contoured against, or harassed
Somatic delusions
Experience bodily functions or sensations when none are present
Loose associations (Knights move/ derailment)
Incoherent thinking, expressed as illogical, sudden, frequent changes of topic
NB- Knight’s move thinking there are illogical leaps from one idea to another, flight of ideas there are discernible links between ideas
Word salad
Incoherent thinking expressed as a sequence of words without a logical connection
Tangential speech
Nonlinear thought expressed as a gradual deviation from a focused idea or question
Neologisms
Creation of new words
Echolalia
Repetition of others words or sentences
Flight of ideas
Quick succession of thoughts usually demonstrated in a continuous flow of rapid speech and abrupt changes in topic (although discernible links between ideas)
Clang association
Using rhyming words rather than words of meaning
Circumstantial speech
Non linear thought expressed as a long winded manner of explanation, with many deviations from central topic, before finally expressing the central idea
Thought blocking
Objective observation of an abrupt ending in a thought process, expressed as sudden interruption in speech
Pressured speech
Accelerated thoughts expressed as rapid, loud, voluminous speech (often in absence of social stimulation)
Schizophrenia
A severe psychiatric disorder characterised by chronic or recurrent psychosis
Psychosis
Distorted perception of reality characterised by delusions, hallucinations, and or disorganised thoughts
Non organic causes of psychosis
Schizophrenia
Mania
Depression
Medication induced
Substance induced
Poisoning eg. Heavy metals/ insecticides etc.
Medications that can induce psychosis
Opiates
Levodopa
Antiepileptics
Corticosteroids
Substances that can induce psychosis
Alcohol
Cannabis
Cocaine
LSD
Glue
Amphetamines
Investigations for first psychotic episode
Bedside- ECG, urine drug screen, urine pregnancy test
Bloods- FBC UE LFT TFT CRP B12 Folate lipids blood glucose (HIV syphilis
serology potentially)
Imaging- MRI head (exclude dementia/ brain injury or disease)
NB- if person is a known schizophrenia/ bipolar, may want to do plasma drug level monitoring (are they compliant with medication eg. lithium levels in a BP patient)
Initial Management of Schizophrenia/ Psychosis
Urgent input from CRT
Section under MHA
Admit to acute psychiatry ward
Oral typical antipsychotic (not clozapine or olanzapine- big SE profile so reserved for more resistant disease) eg. Quetiapine, aripriprazole or risperidone
If necessary IM, or may need IM benzo
Ongoing management of schizophrenia/ psychosis
CMHT, EIT, CRT (crisis) give them access to these services when they need it (tell to make family and friends aware), organise care co-ordinator
Family therapy
Treat co-morbid conditions
Regular health check up’s (lipids, BP, prolactin, etc.)
Advice on lifestyle factors (help with above risk factors)
NB- address co-morbidities (AP therapy is high risk of CV disease)
Psychosis in mood disorders
Mood congruent ie. they fit with the mood
Depression- nihilistic, guilty of a major crime etc.
Bipolar (manic episode)- they have special powers
Schizoaffective disorder
affective disorder (manic and depressive episodes), with psychosis
Antipsychotic use in the elderly
increased risk of VTE and stroke
Causes of neuroleptic malignant syndrome
Antipsychotics
Sudden stopping of PD drugs (either due to lack of absorption (illness/ vomiting/ obstruction (constipation)) or not giving them at the correct time
Management of acute bipolar
Anyone in community with mania- urgent referral to CMHT and CRT
Psychosocial intervention (family therapy)
Medications- lithium is mood stabiliser of choice (also anticonvulsants like valproate or AP like quetiapine). Stop antidepressant during acute mania
Give AP if presenting with acute mania/hypomania
Can also give an antidepressant once mood stabiliser commenced (SSRI eg. citalopram)
NB- address co-morbidities (AP therapy is high risk of CV disease)
Antidepressants and BAD
Antidepressants should not be used before initiating therapy with mood stabilizers because antidepressants can precipitate a manic episode
eg. Stop someone’s mirtazapine/citalopram first
NB- antidepressants can cause a manic shift in undiagnosed BAD patients (follow up in depression is essential- make sure they don’t develop mania)
Features of a manic episode (DIGFAST)
Distractibility
Irresponsibility (sex, money)
Grandiosity (psychotic symptoms)
Flight of ideas
Activity increase
Sleep deficit
Talkativeness
NB- lasts for at least a 7 days
Difference between mania and psychosis
Patients psychotic due to schizophrenia may not be as restless and hyper agitated as manic patients
Illness course is different- patient will be less sick less often in mania (BAD) and will have depressive episodes. Schizophrenic/psychotic patients are constantly I’ll until treated
In mania there is no thought interference, 3rd person auditory hallucinations, running commentary etc.)