Mental Health Flashcards
Monoamine Oxidase Inhibitors
Tryanylcypromine, phenelzine, moclobemide (reversible), and rasagiline
Used for atypical depression
SE’s of MAO-I’s
HTN with tyramine containing foods eg. Cheese, marmite, pickled herring etc.
Anticholinergic
Lithium Monitoring
Check lithium levels 12 hour post dose
After starting, check weekly until stable (resume weekly if dose changes- measure after 1 week)
When stable, every 3 months
Thyroid and renal function checked the every 6 months
Check for pregnancy
NB- give patient an info book, alert card, and record book, check levels during acute illness (dehydration can increase level)
Clozapine use
Treatment resistant schizophrenia/ schizophrenia not managed on 2 or more antipsychotic drugs for at least 6-8 weeks
NB- If clozapine doses are missed for more than 48 hours the dose will need to be restarted again slowly
Clozapine SE’s
Agranulocytosis and neutropenia
Reduced seizure threshold
Constipation
Myocarditis
Hypersalivation
Weight gain and increased apetite
EPSE’s eg, Parkinsonism
Clozapine monitoring
Initial weekly FBC UE LFT for 18 weeks, then 2 weekly for a year, then monthly
Baseline ECG
lipids weight etc.
Antipsychotics monitoring
FBC UE LFT- start and annually
Lipids & weight- start, 3 months and annually
BM & prolactin- start, 6 months and annually (patients can present with polyuria and polydipsia, as antipsychotics can dysregulate glucose)
BP- start and during dose titration
ECG- baseline
CV risk- annually
NB- check not pregnant first
SSRI Interactions
NSAIDs- give PPI
Warfarin/ heparin- consider mirtazapine
Triptan and MAO-I: risk of serotonin syndrome
Tramadol- Serotonin syndrome
Citalopram and QT Interval
Citalopram and escitalopram are associated with dose-dependent QT interval prolongation
Shouldn’t be combined with drugs that do the same
NB- citalopram can also cause torsades de pointes
Drugs that lengthen the QT Interval
Amiodarone
Chlorpromazine
Citalopram/escitalopram
Clarithromycin/erythromycin
Flecanide
Haloperidol
Lithium
Methadone
Ondansetron
Risperidone
Venlafaxine
Atypical vs typical antipsychotics
Atypical are used now due to reduced incidence if EP SE’s eg. Parkinsonism, dyskinesia etc.
They still have SE’s though that the old typical drugs had eg. Galactorrhoea, weight gain, anti cholinergic etc.
Typical antipsychotics
Haloperidol
Chlopromazine
Atypical antipsychotics
Clozapine
Olanzapine
Aripiprazole
Risperidone
Quetiapine
Depression Investigations
FBC, UE, LFT, TFT, B12 and folate, HbA1c, cap glucose
NB- pregnancy test/ BMI/ lipids/ ECG (citalopram, escitalopram, amitriptyline) etc.
Depression Management
Refer to talking therapy (CBT), time off work, lifestyle changes
Moderate-severe: SSRI (if doesn’t work, add another one)
Psychiatry referral: SNRI (after 2 SSRI’s)
When to refer a depressed patient to secondary service (psychiatry)
Treatment has failed (non-response to two treatments)
Significant risk of suicide (harm to others/ severe self-neglect)
Psychotic symptoms
Bipolar affective disorder suspected
Child or adolescent presenting with major depression
Depression relapse prevention
First episode (without risk factors (see when to refer..): 6-9 months after remission (consider 1 year if risks)
High risk patients (>5 episodes or >2 in last few years): 2 years, consider life-long
Assess a patient’s cognition
AMT10
AMT10
Year
Time
Place
Age
DOB
20-1
WW1
Monarch
2 People
Address (1 min and 5 min)
Assess a delirious patient
4AT
4AT
Alertness- 4 if abnormal
AMT4 (Age, DOB, location, year)- 2 if 2 or more mistakes
Attention (Dec-Jan)- <7 (1), untestable (2)
Acute change/ fluctuating- 4
AMT 10 Outcome
> 6 normal
4-6 moderate impairment
<3 severe impairment
4AT Outcome
> 4 high chance of delirium
Delusions of grandeur
Special powers or importance