Mental/Emotional Health + Trauma/Stress And Environment Flashcards

(177 cards)

1
Q

Prodromal phase of psychotic disorders/clinical high risk states

A
  1. Attenuated psychotic symptoms (deviate from normal but not frankly psychotic)
  2. Brief intermittent psychotic symptoms lasting less than a week
  3. Genetic risk and functional decline
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2
Q

Positive symptoms of psychotic disorders

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  1. Hallucinations (perceptions in absence of stimulus, hearing voices or seeing things)
  2. Delusions (disturbances in thought content with a false belief that a person holds true despite evidence to the contrary)
  3. Disorganized speech (loose associations, tangentiality, word salad)
  4. Disorganized behavior (silliness, aggression, catatonia)
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3
Q

Negative symptoms of psychotic disorders

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Blunting of affect
Alogia (decreased speech output)
Avolition: lack of self initiated purposeful activities
Anhedonia
Asociality

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4
Q

DDx: schizophrenia vs schizophreniform vs brief psychotic disorder

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Schizophrenia: at least 2 of 5 key symptoms (1 must be hallucinations, delusions, or disorganized speech. Also may include negative symptoms or disorganized behavior)

Schizophrenia 1 month of active symptoms and 6 months functional impairment

Schizopheniform functional impairment more than 1 month but less than 6 months

Brief psychotic disorder less than 1 month followed by complete remission, often linked to trauma

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5
Q

Differential diagnosis: psychotic disorders vs normal

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Common for children especially less than 13 to have psychotic like symptoms

Features of normal: absence of premorbid difficulties, auditory hallucinations that are non bizarre and related to stressors, absence of delusions, perceptual disturbances that have less impact on behavior, maintenance of social and academic functioning

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6
Q

Differential diagnosis psychotic disorders and ASD

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Lack of reciprocity, flat affect, language delay can be thought of as negative symptoms

Thought content may include preoccupation with fantastic or magical ideas

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7
Q

Management of high risk/prodromal state of psychotic disorder

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Antipsychotics no benefit. SSRI may have benefit

Psychosocial: CBT, cognitive remediation, family psychoeducation

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8
Q

Management of psychotic disorders

A

Meds: antipsychotics

Psychosocial: CBT, cognitive remediation, family psychoeducation

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9
Q

DDx somatic symptom disorder and medical condition

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Somatic symptom disorder feature is psychological distress. This distress is separate from a medical diagnosis, so a medical diagnosis does not negate possibility of somatic symptom disorder

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10
Q

Somatic symptom disorder

A

1 or more somatic symptoms that are distressing or result in significant disruption of daily life. (May be more than 1 symptom and may change over time)

Excessive thoughts/feelings/behavior related to symptom: disproportionate/persistent thoughts about seriousness, high level of anxiety about symptoms or health, excessive time/energy devoted to

Greater than 6 months

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11
Q

Illness anxiety disorder

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Preoccupation with having or acquiring a serious illness

No somatic symptoms or if present mild intensity. If medical condition present or risk of condition, preoccupation is out of proportion

High level of anxiety about health, excessive health behaviors (checking for signs of illness) or avoidance of doctors

Preoccupation for at least 6 months, though the health condition can change

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12
Q

DDx somatic symptom disorder and illness anxiety disorder

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Illness anxiety disorder does not have somatic symptoms present

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13
Q

Conversion disorder = functional neurological symptom disorder

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1 or more symptoms of altered voluntary motor or sensory function (weakness/paralysis, abnormal movements, swallowing/speech, seizures, sensory loss, special senses=hearing,vision)

Incompatibility between symptoms and recognized conditions

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14
Q

Psychogenic non epileptic seizure vs epilepsy

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Unusual to see less than 10 years

Associated with psychological trigger (stressor, trauma, conflict) and dissociative symptoms

Features of PNES: forward pelvic thrusting, side to side head and body movements, closed eyes resistant to opening, lack of postictal confusion

May co occur with epilepsy, can get an EEG

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15
Q

10 common signs of dissociation in children

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  1. Amnesia for significant or traumatic events
  2. Frequent dazed or tranced states (blank staring and lack of connection to surroundings)
  3. Forgetting previously mastered concepts
  4. Regression
  5. Difficulties with cause and effect consequences from life experience
  6. Lying or denying misbehavior despite obvious evidence
  7. Repeatedly referring to oneself in 3rd person
  8. Unexplained injuries or recurrent self injurious behavior
  9. Vivid imaginary companionship involving control of child’s behavior
  10. Auditory and visual hallucinations
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16
Q

Example of normal dissociative episode

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4 year old playing with imaginary friend or other fantasy behaviors that are short lived and can integrate normal streams of consciousness

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17
Q

Dissociative identity disorder

A

2 or more distinct personality states with marked discontinuity in sense of self and agency plus alterations in affect, behavior, consciousness, memory, perception and cognition

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18
Q

Dissociative amnesia

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Inability to recall important autobiographical information usually if a traumatic or stressful nature

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19
Q

Depersonalization/Derealization disorder

A

Depersonalization = experiences of unreality, detachment or being an outside observer with respect to thoughts, feelings, sensations, body or actions

Derealization: experience of detachment with respect to surroundings

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20
Q

Lifetime prevalence of depression in adolescents

A

11-15%
1/7

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21
Q

Gender, age, and depression risk

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Risk increases with age
In childhood gender balanced, after puberty more girls

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22
Q

One of the strongest predictors of depression

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Parent with depression: 1st degree relative with depression risk is 31-42%

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23
Q

Presentation of depression in young children

A

Somatic complaints
Irritable (rather than sad) mood

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24
Q

Depressive episodes and recurrence

A

Average episode 27 weeks
80% have recurrence
Longer the remission, lower the recurrence risk
Risk factors for recurrence: younger age, multiple episodes, more severe episodes

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25
Major depressive disorder criteria, time frame, and symptoms
Lasting at least 2 weeks Depressed mood AND/OR anhedonia PLUS At least 5 of: Change in sleep patterns Feelings of guilt/worthlessness Decreased energy/fatigue Decreased concentration, indecisiveness Changes in appetite Psychomotor retardation/agitation Suicidal ideation
26
Persistent depressive disorder criteria, time frame, and symptoms
At least 1 year Persistent dysphoric mood and at least 2 of: Loss of interest Change in appetite Change in sleep Low energy/fatigue Low self esteem Decreased concentration/indecisive Hopelessness
27
Disruptive mood dysregulation disorder criteria and time frame and ages to diagnose
Severe recurrent verbal and/or behavioral outbursts at least 3 times per week PLUS Persistent angry/irritable mood most of the day nearly daily in at least 2 settings for 1 year without break longer than 3 months Symptoms present by age 10, don’t diagnose before 6 or after 18
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3 evidence based psychotherapies for depression
CBT IPT DBT
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Cognitive behavioral therapy
Connect relationship between thoughts, feelings, and behaviors Targets behavioral activation and challenging cognitive distortions
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Interpersonal psychotherapy
For depression: Recommend for severe depression, comorbid anxiety, or high conflict with parents and peers Helps improve problem solving in relationships
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Dialectic behavior therapy
Targets treatment engagement, emotion regulation, distress tolerance For self harm and NSSI
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Keys that differentiate a bipolar disorder
1) decreased need for sleep over repeated days that is a significant change from baseline without explanation and feels well rested 2) grandiosity 3) hypersexuality 4) lack of judgment or insight
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Red flags for bipolar disorder in adolescents
Rage outbursts Verbal or physical aggression Little sleep Spontaneous mood changes Running away Spending money impulsively Hyper sexuality Grandiosity Agitation/mania with SSRI
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Manic episode criteria
At least 1 week Abnormally elevated or expansive or irritable mood and increased energy or goal directed behavior At least 3 associated symptoms: grandiosity/inflated self esteem, decreased need for sleep, racing thoughts/flight of ideas, distractibility, increased talkativeness, psychomotor agitation, impulsivity/reckless behavior, involvement in pleasurable activity with high risk of consequences
35
Hypomanic episode vs manic episode
Manic at least a week, hypomanic at least 4 days (hypomanic can be shorter) Less severe and does not impact functioning as extremely
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Bipolar I vs Bipolar II
Bipolar I at least 1 manic episode Bipolar II at least 1 major depressive and 1 hypomanic
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Major depressive episode criteria
At least 2 weeks Major depressive disorder symptoms (depressed mood and/anhedonia and at least 5) -change in appetite -change in sleep -psychomotor retardation/agitation -low energy/fatigue -decreased concentration, indecisiveness -guilt/wothlessness -suicidality
38
Cycylothymic disorder criteria
Hypomania and major depressive symptoms that don’t meet criteria for bipolar disorder over at least 1 year, no period of stable mood at least 2 months at a time
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First line treatment for bipolar disorder
2nd generation antipsychotics (aripiprazole) Lithium second line
40
Most powerful predictor of suicide
Prior suicidal behavior (includes suicide attempts and NSSI)
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Suicide screeners
ASQ questions Columbia
42
Elements of suicide safety plans for youth and caregivers
Youth: 1) elicit 3 strengths about self and family/environment 2) emotional thermometer to understand emotional reactions 3) engage in identifying behaviors, thoughts and interpersonal strategies that can be used instead of self harm 4) list of at least 3 support people 5) commitment from youth Caregiver 1) elicit 3 strengths about youth and family/environment 2) explain importance of lethal means restriction and immediate steps for safety 3) work to support youth and caregiver in using the safety plan
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Most common reasons for nonsuicidal self injury
Reduce negative emotions and stress Resolve interpersonal difficulty
44
Onset and risk factors for nonsuicidal self injury
Onset 12-16 Increased risk in sexual minority youth Social exclusion and bullying
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4 presentations of anxiety that could look like other things
1) refusal behaviors/oppositionality 2) poor concentration/inattention 3) somatic complaints 4) irritability
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Temperament associated with anxiety
Behavioral inhibition, slow to warm
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Anxiety and family factors (genetics and environment)
1st degree relative 4-6x more likely Heritability 30-50% Parental overprotection and parental modeling (anxious parent, anxious child in bidirectional relationship)
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Separation anxiety key features and duration
Normal developmental response 10mo to preschool Fear of separation from home/caregiver or something bad happening to caregiver Can present with behavioral outbursts or physical symptoms Duration at least 4 weeks
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Social anxiety key features and duration
Fear of drawing attention to or embarrassing self in front of peers Duration at least 6 months
50
Most common anxiety disorder in adolescents
Social anxiety disorder
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Specific phobia duration and key features
Fear of specific object or situation that provokes immediate anxiety and is avoided or endured with fear/anxiety In children can present as crying, tantrums, freezing, clinging Duration at least 6 months
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Generalized anxiety disorder key feature and duration
Excessive anxiety and worry about a number of events/activities (avoidance of things typical peer would do), difficult to control worry Other features: restlessness/on edge, easily fatigued, difficulty concentrating, irritability, muscle tension, sleep disturbance At least 6 months
53
Selective mutism key features duration and diagnosis
Failure to speak as expected in social situations despite talking in other situations (at home with family) More common in younger children and more apparent on entry to school May use nonverbal skills, may have history of language delay (but not due to communication disorder) At least 1 month, not during first month of school Diagnosis made with behavioral ratings from parents, teachers, and other individuals
54
Panic disorder key features
Recurrent unexpected panic attacks or panic attack followed by at least a month of worry about more attacks or maladaptive behavior changes related to attacks (avoiding settings) Attacks: Abrupt surge in fear or discomfort that peaks within minutes. Physical symptoms (palpitations, heart racing, sweating, shaking, trembling, shortness of breath, chest pain, feeling of choking, nausea/abdominal distress, dizzy/lightheaded, chills or heat feeling, numbness/tingling) Depersonalization/derealization Fear of losing control or fear of dying
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Obsessive compulsive disorder
Obsessions AND/OR compulsions Must be time consuming (more than an hour a day)
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Obsessions
1) recurrent and persistent thoughts, urges, or images that are intrusive and inappropriate; cause marked distress or impairment 2) attempts to suppress or ignore these or neutralize with some other thought or action
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Compulsions
1) behaviors that individual feels compelled to perform in response to obsession or rules that individual thinks must adhere to 2) repetitive behaviors or mental actions done to prevent or reduce dreaded situation
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Differential ASD and OCD
In ASD repetitive behaviors not tied to attempt to reduce anxiety about specific situation
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Elements of CBT for anxiety
1) psychoeducation 2) skills training for somatic manifestations, relaxation 3) cognitive restructuring 4) exposure via desensitization, habituation 5) relapse prevention
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Exposure and response prevention
Graduated exposure to anxiety provoking stimuli and preventing compulsive behavior
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Behavior therapy for anxiety
Graduated/gradual exposure to fear stimulus focused on decreasing avoidance
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Treatment of anxiety disorders
First line is CBT CBT plus SSRI for moderate to severe
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Reasons for school refusal
Anxiety (any type of anxiety disorder) Depression Learning disability Social concerns (lack of friends, bullying, parental illness or separation)
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Management of school refusal
First figure out what is causing it address it (eg CBT for anxiety) Psychoed: why avoidance of school makes anxiety worse Good daily routine *Return to school plan: can be 1–2 classes per day, no reinforcement at home, safe location to go for few min if super anxious
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School refusal vs truancy
Truancy is related to conduct disorder School refusal related to anxiety
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Adjustment disorder timing
Arise within 3 months of stressor Resolve within 6 months. After 6 months: If symptoms persist beyond the stressor, change the diagnosis. If the stressor persists, then chronic adjustment disorder
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Differential diagnosis of adjustment disorder
Normal stress response or bereavement Another mood or behavior diagnosis (won’t have the clear stressor) Trauma or stressor disorder (stress response significant and characteristic of)
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Types of adjustment disorder
Anxiety Depressed mood Anxiety and depressed mood Disturbance of conduct Disturbance of emotions and conduct Unspecified (social withdrawal, decline in academics)
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Primary, secondary, and tertiary treatment and prevention for adjustment disorders
1. Build resiliency, language development, promoting relationship 2. At risk kids (nurse/counselor visits) 3. Relaxation/visualization, CBT, creative expression, family counseling. Think about the setting (school, home, peers). No pharmacotherapy
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SSRI mechanism of action
Selectively block serotonin reuptake. Increases amount of time serotonin can act on post synaptic sites. Also downstream effects (full effect weeks after initiation) with increase in brain naturetic peptide and modifications to serotonin receptor
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When and how to start SSRI and when does it start to work
Start if symptoms continue with 6 weeks of CBT alone or can start in combo with CBT for moderate to severe. Start and low dose and increase every 2-3 weeks monitoring for effectiveness and side effects Start to show positive effects within 4-8 weeks and some positive results as early as 1-2 weeks
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GI side effects from SSRIs
Nausea, vomiting, diarrhea, cramping due to gut serotonin receptors. Usually resolves in 2-4 weeks and a slow titration helps
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Behavioral activation from SSRI: features and management
Hyperactivity, restlessness, irritability, disinhibition, impulsivity after starting SSRI Most common in prepubescent Manage by decreasing dose, discontinuing or changing medication
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Black box warning for SSRI
Increased suicidal thoughts or actions For first 9 days after starting or increase in dose, 4% vs 2% with placebo. No completed suicides Not a reason not to prescribe, increased prescription actually decreases suicide rates
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Serotonin syndrome triad
1) Mental status changes 2) autonomic hyperactivity 3) neuromuscular abnormalities
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How and when to discontinue or switch an SSRI
Continue 6-12 months after remission of symptoms If no or partial response after 6-8 weeks switch To discontinue/switch taper over 1-2 months to avoid withdrawal symptoms.
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SSRI withdrawal symptoms
The longer the half life the less likely to experience withdrawal Dizziness/lightheadedness Fatigue/drowsiness
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SSRIs approved for depression and ages
Fluoxetine 8 and up Escitalopram 12 and up
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SSRIs approved for anxiety and ages
OCD: sertraline 6 and up, fluoxetine 7 and up, fluvoxamine 8 and up Generalized: escitalopram 7 and up (new as of 5/2023) Duloxetine (SNRI) approved for GAD 7 and up
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What SSRI should you prescribe if worried about missed doses?
Fluoxetine Long half life
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Which SSRI has more side effects and withdrawal symptoms
Paroxetine (Anticholinergic side effects)
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Key differences DMDD vs ODD vs IED
DMDD temper outbursts not necessarily related to being argumentative or defiant (poor frustration tolerance out of proportion). IED also can be provoked by a lot of things and can be verbal/physical w/o property destruction or with. IED is also more impulsive, not premeditated. ODD had losing temper/anger but also argumentative/defiant/vindictive/blaming others or annoying them. In DMDD outbursts occur at least 3 times per week for at least 12 months. In ODD if less then 5 yrs on most days but if 5 or older can be 1x/wk for 6 months. IED w/o damage 2xwk for 3 months, with damage 3x in 3 months Ages: DMDD and IED not before 6 DMDD has the mood component (angry/irritable mood persistent between outbursts). Not true with ODD and IED Overall DMDD is more severe and if criteria met for both its DMDD
83
Aggression in infants
Often developmentally appropriate exploration of environment. Also biting with teething and frustration. Calm correction, provide alternatives, provide practice of skills
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Aggression in toddlers
Often result of strong emotions without effective language or emotional self control Provide warnings for transitions, social stories, remain calm, identify child’s feeling and goals and for older kids point out consequences l. Manage expectations and praise small steps
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Aggression in older children and teens
Result of poor social problem skills and lack of behavioral self awareness Interventions parent behavior management training and CBT Impact of media exposure: violent media leads to aggressive behavior and desensitizes violence
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Thumb sucking -when to treat -management
Don’t treat if 4 or younger (only thing is positive behavior support) Tx: positive behavior support, habit reversal, orthodontic appliances, barrier (glove, splint), chemical nail polish. Behavioral has most evidence
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Hair pulling
< 6 years: usually self limited habit. Older children and adolescents: more chronic and associated with anxiety, depression Tx habit reversal, blocking, positive reinforcement. SSRI and NAC in adults
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Nail biting
Can be due to anxiety but also boredom and frustration Treatment is behavioral intervention and good nail hygiene
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Picking of skin and nose
Management by blocking access SSRI and NAC have shown improvements
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Head banging
5-19% of infants and toddlers. Often at bedtime or when frustrated Provide reassurance, ignore behavior Pad surfaces If more severe and persistent with developmental disability, helmet or meds
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Habit reversal therapy
Increase awareness of habit Teach competing response to habit Review associated problems
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Breath holding spells Types, differential, and management
Cyanotic: often preceded by anger frustration leading to intense crying. Pallid: more likely to be provoked by fear or pain. Less crying. Can be mixed DDx vs medical cause: provoking factor and color change Treatment reassurance
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Psychogenic illness: important first step
Acknowledge reality of patients experience/symptoms Avoid phrases like “there’s nothing wrong with you”
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Stress response in the brain (And difference between stress types)
Stress activates PFC and hippocampus PFC and hippocampus stimulate amygdala Amygdala activates HPA HPA releases cortisol Tolerable stress: cortisol rise is transient, levels return to baseline through negative feedback loop Toxic stress: amygdala can’t be inhibited, negative feedback loop is not effective, cortisol chronically high
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Exposure to violence: signs in young children/preschoolers
Difficulty with sleep Difficulty with separation Somatic complaints (in older preschoolers)
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Exposure to violence: signs in school age
Anxiety Aggression Poor sleep Poor school functioning
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Child abuse risk factor with greatest risk of death
Age (<3)
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Most common form of child maltreatment
Neglect (Children living in poverty 12x more likely to experience)
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Signs of emotional/psychological abuse
Internalizing (anxiety, depression, shame, perfectionism) Externalizing (aggression, hyperactivity, oppositional/defiant, inappropriate, irresponsible, provocative) Signs of disorganized attachment: clinginess, social disinhibition
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Signs during a visit that may be concerning for neglect and what to do:
Developmental delay, lack of parental knowledge about development, attachment issues What to do: screen for parental depression
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Steps to take after a disaster
First is meet basic needs: food, shelter, safety, supervision. Mental health screening and support is also critical What to ask about? —> ask what they already know and have heard (look for misinformation, misunderstanding, misconceptions); ask about worries/questions/concerns; don’t minimize concerns, listen actively and emphatically; provide info in simple and direct terms; identify risk factors for adjustment problem; offer coping strategies; get back into routine Refer for behavior support Provide guidance on what may be seen (sleep problems, eating changes, depression, anxiety, difficulty concentrating, substance use, risk taking behavior, somatic symptoms, developmental or social regression) and that can worsen preexisting issues (financial problems, parental mental health)
102
Relational aggression
Bullying behavior causing harm within relationships at the individual or group level (spreading rumors, exclusion, threat to stop talking to) Victims are more likely to experience peer rejection, have poor peer relationships, fewer prosocial problem solving skills Aggressors more likely to be popular and use aggression to advance or protect their status. They also may have poor psychological and social adjustment, poor academic performance.
103
Ostracism
When person is ignored and made to feel non existent. Consist of withdrawing eye contact with, response to, and recognition of another person. Consequences may include sadness, hurt feelings, change in social perception (interpreting ambiguous situations as threatening)
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Risk factors for adjustment difficulties after a disaster
1) Previous psychopathology 2) Significant losses or other traumatic events 3) attachment disturbances 4) socioeconomic differences (level of post disaster resources and support) 5) nature of the disaster (injury of child or injury/death of those close to child, nature and extent of exposure (human made create more prevalent and long lasting reactions), extent of exposure (even indirect through media), child’s perception at the time of the event that life in jeopardy 6) subsequent factors (separation from caregivers, loss of property or belonging/need to relocate, parental difficulties coping/mental health/substance abuse), lack of supportive family communication style, lack of community resources/support)
105
Concepts related to death (and age of understanding)
Age 5-7 Irreversibility: death is permanent Finality: no life functions (can’t be cold, in pain, or hungry) Inevitability: natural phenomenon, no one is immortal Causality: realistic causes of death (not caused by child’s own thoughts or actions) Guilt is commonly expressed after death of someone close (what they did or failed to do to contribute)
106
Response to death: age 3-5
When’s my mom coming home? Preoperational thinking, difficulty understanding illness and permanence of death. Give scripts to explain
107
Response to death age 6-8
“I think I killed her” Late preoperational thinking with both magical and logical thinking. Better understanding of permanency of death. Simple explanations about causal relationship, discuss prognosis when death imminent Children may make logical errors when misunderstanding cause and effect
108
Response to death age 9-11
“Just give me the facts” Concrete operational thinking. Better able to use logical thinking and cause and effect, Benefit from detailed, concrete explanations of disease and treatment
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Response to death age 12-14
“I cry in my room alone” Inconsistent formal operational thinking. May be egocentric and callous
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Response to death age 15-17
“So much has changed, nothing will be the same again” Consistent formal operational thinking, grief similar to adults. More allocentric and empathic
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Reactive Attachment Disorder
Consistent pattern of emotional withdrawal toward others including minimal response to comfort from caregiver or lack of seeking comfort in time of stress Symptoms: limited social/emotional responsiveness toward others, limited expression of positive affect, periods of irritability/sadness/fear during nonthreatening adult interaction. History of insufficient care: neglect, multiple changes Symptoms appear before age 5 and developmental age at least 9 months With stable/supportive environment, can develop new patterns Intervention: therapy If untreated, higher rates of psychopathology DDx: ASD would have RRBs Trauma disorder would have specific event
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Traumatic event for PTSD
Exposure to actual or threatened death, serious injury, or sexual violence by: 1) direct exposure 2) witnessing 3) learning about events to close family member/friend
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Symptom clusters in PTSD
1) Intrusion: distressing memories, dreams, flashbacks, dissociation, prolonged psychological distress or physiological reactions to cues 2) avoidance: avoidance of distressing memories/thoughts/feelings or of external reminders 3) mood/cognition: inability to remember aspects, exaggerated negative self beliefs, distorted sense of blame, persistent negative emotional state, feels of detachment, decreased participation 4) arousal/reactivity: irritable behavior/anger outbursts, reckless or self destructive behavior, hyper vigilance, exaggerated startle, problems with concentration, sleep disturbance
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Diagnosis of PTSD in children 6 and under vs older
Diagnosis is 1 intrusion + 1 avoidance + 2 mood/cognition + 2 arousal/reactivity In children 6 and under: 1 intrusion + (1 avoidance OR 1 mood/cognition) + 2 arousal/reactivity
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Duration differences in acute stress vs PTSD
Acute stress: 3 days to 1 mo PTSD: greater than a month
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Risk factors for PTSD
Previous history of anxiety Women > men Type of event: violence/abuse > natural disasters Severity and chronicity of trauma Environment after traumatic event (lack of support, ongoing adversity) increases risk of chronic PTSD symptoms
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Treatment PTSD
***trauma focused CBT Child parent psychotherapy in under 6
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CMV neurodevelopmental outcomes
Leading nongenetic cause of SNHL, progressive over childhood even in infants without signs at birth Increased risk of CP, developmental delays, autism. Intracranial findings increases risks
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Name the congenital infection -Fever, rash, chorioretinitis, intracranial calcification, hydrocephalus -at risk for vision loss, hearing loss, seizures, cognitive and motor delays
Toxoplasmosis Most (80-90%) asymptomatic Caring for cats
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Name the congenital infection : -cataracts, congenital heart defects, SNHL, microcephaly
Rubella Heart defect: PDA High perinatal mortality rate and preterm birth Rare in US —> unvaccinated or outside US
121
Name the congenital infection: -rash desquamation involving palms and soles, jaundice, hepatosplenomegaly, rhinitis, skeletal abnormalities -vision/hearing loss, CP, seizures, cognitive delay, speech/language delay -late: bone pain, retinitis pigmentosa, peg shaped upper central incisors, interstitial keratitis, saddle nose
Syphilis Most infants are symptom free On the rise in US and persists in low income countries
122
Name the congenital infection -rashes, CNS findings (hydrocephalus, white matter lesions, seizures, encephalitis), ophthalmologic -vision loss, severe motor and neurologic impairment
HSV True congenital infection rate (neonatal/perinatal)
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Congenital infection that causes fetal anemia
Parvo B19
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Name the congenital infection: -skin lesions, neurologic and eye defects, limb hypoplasia -symptoms at birth associated with later developmental/behavioral outcomes
Varicella
125
Name the congenital infection -severe microcephaly, brain and ocular abnormalities, congenital contractures, seizures, spasticity
Zika Mosquito bite aedes species (central/South America, Southeast Asia, Africa) Cognitive outcomes associated with head circumference at birth
126
How to screen for iron deficiency
Ferritin and inflammatory marker, Hb checks anemia which is a late finding Can have cognitive/developmental impacts without anemia Early treatment of iron deficiency does not lead to complete brain recovery
127
Nutrient critical for thyroid hormone synthesis and risks if deficient
Iodine Severe deficiency in first trimester: cretinism. IQ 30 with deficits in hearing, speech, and gait Improvement with supplementation before 10 weeks
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Nutrient essential for myelination and neuronal development, common reasons for deficiency, and symptoms of deficiency
B12 Maternal: pernicious anemia, strict vegetarian diet, gastric bypass Symptoms at 4-10 months: failure to thrive, developmental regression, tremors, hypotonia, lethargy, irritability
129
Alcohol mechanism of harm (and when most harmful)
Interference with neuronal migration, impaired development and function of neurotransmitter receptors, neuronal necrosis, reduced brain volume Harmful at all stages. First trimester, most likely to be associated with facial anomalies and major structural abnormalities.
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Definition of documented alcohol exposure (5 things)
1. Six or more drinks per week for two or more weeks. 2. Three or more drinks per occasion on two or more occasions. 3. Documentation of alcohol use on a screening instrument during pregnancy. 4. Alcohol related, social or legal problems. 5. Positive test.
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Criteria for fetal alcohol syndrome (Including classic facial features)
*** can diagnose in absence of documented exposure A) at least two facial features (short palpebral fissures, thin vermillion border/upper lip, smooth philtrim) B) growth deficiency C) structural neurologic or functional central nervous system abnormalities D) Neuro behavioral impairment, characterized by cognitive impairment and or behavioral impairment and for younger children, developmental delay (emotional dysregulation, ADHD symptoms, learning and memory problems)
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Criteria for partial fetal alcohol syndrome (with and without documented exposure)
With documented exposure: A) two facial features, D) Neuro behavioral Without documented exposure : A) two facial features; B) growth deficiency OR C) structural neurologic or functional CNS abnormality; D) Neuro behavioral impairment
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Criteria for alcohol related neurodevelopmental disorder
Documented exposure + D) Neuro behavioral impairment Cannot diagnose less than three years
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Most common Neuro developmental disorders associated with fetal alcohol syndrome
ADHD (50%) Intellectual disability (23%) Learning disability (20%) Oppositional, defiant disorder (16.3%) Anxiety and depression (14.1%)
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Nicotine exposure -mechanism -DBP outcomes
Mechanism: interference with signaling among progenitor cells during brain development, epigenetic effects may play a part Outcomes : ADHD, conduct problems, depression, and anxiety, SNHL
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Valproic Acid effects
Neural tube defects Dysmorphic craniofacial features Microcephaly Congenital heart disease Limb abnormalities GU abnormalities Developmental delay is especially speech and language Decreased full scale, IQ, with verbal more affected then nonverbal Deficits of working memory Increased autism spectrum disorder Increased ADHD
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SSRI exposure Mechanism and outcomes
Mechanism: affect HPA axis, and induce epigenetic changes Increased pre-term birth, lower birth weight Neonatal behavioral syndrome due to effects of withdrawal or increased serotonergic tone (hypothermia, vomiting, frequent stools, feeding difficulties, poor sleep, excessive, crying, agitation, irritability, tremors, seizures, hypoglycemia, hypertonia, hyperreflexia) Lower psychomotor developmental scores, increased ASD though studies show variable outcomes Untreated maternal depression may itself negatively affect child’s development, consider risk versus benefit of continued treatment
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Lithium exposure effects
Perinatal toxicity (hypotonia, heart failure, nephrogenic DI) Ebstein’s anomaly (tricuspid valve disease)
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Cocaine exposure: mechanism and outcomes
Peripheral vasoconstriction leads to decreased blood flow to the placenta which affects intrauterine growth Increased dopamine activity in the fetal brain affects neural migration. Frontal lobes, particularly vulnerable. Poor cognitive and speech and language skills increased learning disabilities, externalizing behavior
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Opioids exposure: mechanism and outcomes
Altered levels of neurotransmitters, altered neurogenesis IUGR , small fetal heads circumference, neural tube defects, congenital heart defects Delays in cognitive motor and speech, language development, lower IQ and academic achievement, increased attention and behavior problems. However, difficult to determine if long-term effects solely due to opioid or multiple confounders. Neonatal opioid withdrawal syndrome : excessive, crying, poor sleep, hyperactive Moro, tremors, myoclonus, increased muscle tone, excretion, modeling, fever, nasal, stuffiness, sweating, difficulty breathing for feeding vomiting, diarrhea, failure to thrive, excessive irritability)
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Cannabis exposure: outcomes
Limited literature on CBD effects Lower birth, weight, executive functioning deficits, poor, academic achievement, increased hyperactivity, impulsivity, and in attention, increased delinquency, depressive symptoms
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Amphetamines exposure: mechanism and outcomes
Methamphetamine neurotoxic effects on dopamine and epinephrine containing cells and affect areas of the brain associated with attention and behavior Imaging abnormalities in frontal right matter and smaller subcortical volumes in the putamen, globus pallidus, and hippocampus Increased externalizing and rule, breaking and aggressive behaviors
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Lead -reference value -most common source -outcomes
5mcg/dL Lead laden dust and paint chips Outcomes: long lasting sequela on intellectual and academic achievement later in childhood, even after low level exposures. Cognitive damage, hearing loss, visual effects, delayed speech, learning disabilities, decreased reading in math skills, poor attention, executive functioning deficits.
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Mercury -source -outcomes
Severe poisoning has become rare. However, a more insidious concern is of chronic exposure, resulting from contamination of the food chain, especially certain species of fish. Methylmercury is a potent neurotoxin and the adverse effects include dose related reduction and IQ, shortened detention span, irreversible, neurologic, and developmental effects More recent concern is on more subtle neurocognitive effects that may be attributed to chronic low level exposure Recommend no more than one serving per week of albacore, tuna, swordfish, shark, king, mackerel, and, Spanish mackerel
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Organophosphate -mechanism -outcomes
Inhibit activity of acetylcholinesterase Damage to cognitive abilities, changes in behavior and developmental delays, higher rates of autism and ADHD even low to moderate levels of exposure associated with persistent changes in brain structure and function
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Name the congenital infection -rash, jaundice, thrombocytopenia, hepatosplenomegaly, SGA, microcephaly, periventricular calcifications, hearing loss
CMV 90% asymptomatic at birth Hearing loss not always present at birth, onset delayed in up to 40%.
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CMV diagnosis
Screening for congenital CMV has become more common and is mandated in some states typically after failure of newborn hearing screen Definitive diagnosis requires proof of viral presence in the newborn period. Urine blood or salivary samples in the first 21 days confirmed by PCR.
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CMV management
If infant is symptomatic during the first month, antiviral treatment can be effective in reducing hearing loss and developmental and cognitive disabilities risk with antiviral treatment is neutropenia If diagnosed audiology and ophthalmology are warranted . Audiology every 3 to 6 months until age 3, and then annually until at least age 6.
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Isoretinoin exposure
Cranial facial abnormalities (cleft palate, ear abnormalities, micropthalmia, micrognathia, abnormally shaped skull, microcephaly) may affect cardiovascular system thymus parathyroid CNS
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Substance use risk factors
Genetics Age at first use (younger age) and having friends that use Family history Lack of parental investment in activities of their children Personality: low assertiveness, low self esteem, low self efficacy, low social confidence, external locus of control Social determinants of health
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CRAFFT screening
Part A: during last 12 months, how many days did you 1) drink more than a few sips of alcohol 2) use marijuana, 3) use anything else to get high Part B If all 0s in part A then ask C only C: have you ever ridden in a Car w someone (including yourself) who was high or using R: have you have used to Relax, feel better about yourself or fit in A: did you ever use Alone F: do you ever Forget things you did F: do your Family and Friends ever tell you to cut down T: have you ever gotten in Trouble
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Labs/Drug testing
Avoid drug test at request of parents or legal authorities Many use drugs sporadically making lab testing unreliable Serum half lives are brief so urine testing reflects 24-48 hrs with exception THC
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Treatment of SUD
Psychosocial: CBT, family therapy Family based interventions have most evidence Medical/psychaitric: detoxification, medications (methadone, nicotine replacement), acute or long term residential Long term=highly structured program 30-90 days, some up to a year
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Substance use disorder criteria
Problematic pattern of use leading to clinically significant distress or impairment manifested by at least 2 of the following in a 12 month period: 2-3=mild, 4-5=moderate, 6=severe 1. Substance taken in larger amount or over longer period than intended 2. Persistent desire or unsuccessful efforts to cut down or control 3. Great deal of time spent in activities to obtain, use, and recover from effects 4. Craving or strong desire to use 5. Recurrent use resulting in failure to fulfill major obligations at work, school, home 6. Continued use despite having persistent or recurrent social or interpersonal problems caused or exacerbated by effects of substance 7. Important social, occupational or recreational activities given or or reduced because of substance use 8. Recurrent use in situations in which it is physically hazardous 9. Continued substance use despite having recurrent physical or psychological problems that is liked to have been caused by or exacerbated by the substance 10. Tolerance: need for markedly more to achieve intoxication OR markedly diminished effect with continued use of the same amount 11. Withdrawal: a characteristic withdrawal syndrome OR substance taken to relieve or avoid withdrawal
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5 R talking points for brief counseling
1. Review: for each yes response to screener tell me more about that 2. Recommend: not to use “as your doctor my recommendation is not to use XX because they can YYY” 3. Riding: driving risk counseling 4. Response: for non user “if someone asked you why you don’t XYZ, what would you say” and for users “what would some of the benefits be of not using” 5. Reinforce: self efficacy “ I believe you have what it takes to keep use from getting in the way…”
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What to do if there is cyber bullying
Save examples (descriptions, screenshots, texts, dates and times). Don’t respond to or forward messages and should block the person Can report to internet service providers and social media sites Sending threats of violence, sexually explicit photos or messages, images from a place where privacy is expected along with stalking and hate crimes is criminal and should be reported to law enforcement
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Benefits of social media use and problems with restricted access
Benefits: identity development, aspirational development, peer engagement, support for those in marginalized communities Restricting social media can increase social withdrawal and isolation
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Family media plan
Helps families develop rules and guidelines about screen time. Suggestions for screen free times and zones, choosing what media will be used, balancing activities, safety and good digital citizenship
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Internet gaming disorder -criteria -duration
Disorder in which individuals participate in gaming in a persistent and recurrent manner which can lead to clinically significant distress/impairment 5 of 9 within 12 months: -preoccupation with games -withdrawal when game taken away (irritability, sadness, anxiety) -unsuccessful attempts to reduce or control game participation -loss of interest in real life relationships or activities -continued excessive use despite awareness of psychosocial problems -deceit about amount of gaming to others (family, therapist) -use of games to escape or relieve a negative mood -jeopardized or lost a relationship/job/educational opportunity due to participation
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Internet gaming disorder -risk factors
Internal: executive functioning and mood/reward system dysregulation, avoidant behaviors, low self esteem. ADHD, depression, social anxiety, ASD External: poor parent and peer relationships, poor parental control and negative role models, family violence, single parent
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Best way to prevent firearm injury
Complete absence of guns is best. Or limit access (store locked and unloaded) Limited evidence that gun education programs are effective No direct causal link between exposure to violent media and firearm usage or injury. However some children may be more susceptible to exposure to violent media and violent media may desensitize children to violence or normalize violent behavior
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Parent role (and 3 ways parents can scaffold media consumption)
1. Coviewing: watching show together 2. Instructive mediation: teaching or talking about what children are viewing 3. Restrictive mediation: setting limits and choosing what children view Parents must manage their own behavior
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Media and health outcomes
Insufficient sleep (recommend limiting screens before bed and limiting screens in bedroom) Obesity Language development: greater media associated with lower language skills; higher quality educational programming and coviewing associated with higher skillls Executive functioning: association between greater media use and challenges with EF, possibly in bi directional way
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Media recommendations by age: infants
Limit to video chatting and provide ample time for other enriching activities
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Media recommendations by age: toddlers/preschoolers
Choose high quality educational content and watch together when possible, limit to an hour or less per day
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Media recommendations by age: school age
Choose high quality educational content, watch together when possible, reflect with your child on digital media and promote digital citizenship, provide ample time for other developmentally enriching activities
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Media recommendations by age: adolescents
Limit distractions when completing schoolwork, supervision of social media accounts
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8 Red flags for factitious disorder by proxy
1) History inconsistent with direct observation 2) inconsistent histories from other medical visits 3) recurrent, unexplained, prolonged illness 4) multiple medical visits, tests, interventions 5) multiple symptoms reported by caregiver 6) symptoms only seen by caregiver 7) improvement in symptoms only when away from caregiver 8) siblings of children who have been victims of abuse or factitious disorder
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If factitious disorder suspected, next step is:
Working with interdisciplinary child protection team (child abuse pediatrician, referral to CPS) Do not confront the parent in the room without gathering past records or consult with child abuse specialist Discontinuing any medical tests or treatments that are not indicated is crucial (don’t do more tests)
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If a child in a question has a lot of ACEs (parent incarceration, domestic violence, substance abuse, mental illness) and child has behavior issues and parent appears disengaged in a visit, the answer is:
Screen the parent for depression Resilience promoted by safe stable relationships with immediate family
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Diagnosis of conduct disorder and children, younger than 10
A diagnose of conduct disorder is made when recurring behaviors occur at least one of the following categories for at least 6 months: aggression toward people and destruction of property, lying, and theft, other violations of rules
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Management of conduct disorder
Prioritize as assessment for and treatment of co-occurring conditions, ADHD anxiety, depression, ODD Behavioral therapy Partner with school and community organizations
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Understand lying and stealing, age
Age 6
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Reasons why kids lie
Younger children because they are testing a new behavior I want to boost their self-esteem or gain approval Older children because they don’t want to disappoint their parents
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Reason why kids steal
Because they want something they do not have or an anger or retaliation
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Brain changes with toxic stress
Decrease in corpus callosum volume
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Vegan diet concerns
Often deficient in vitamin B 12, protein, and fatty acids