Menstrual cycle and it's disorders Flashcards
What is puberty?
The onset of sexual maturity, marked by the development of secondary sex characteristics
Which axis stimulates menstruation?
The hypothalamic-pituitary axis
Where does menstruation fit into puberty?
It is normally the last manifestation in puberty
What hormones stimulate first menarche?
GnRH pulses increase in amplitude and frequency, such that pituitary FSH and then LH release increases. These stimulate oestrogen release from the ovary
Which hormone is responsible for the secondary sexual characteristics?
Oestrogen
In what order does puberty take place?
Breast development -> pubic hair -> menarche
What is thelarche?
Beginning of breast development
What is adrenarche?
Growth of pubic hair
What takes place on days 1-4 of the menstruation cycle?
Menstruation
What takes place during menstruation?
The endometrium is shed as it’s hormonal support is withdrawn. Myometrial contraction, which can be painful, also occurs
What phase takes during days 5-13 of the menstrual cycle?
Proliferative phase
What hormones do the follicles produce during the follicular phase?
Oestradiol and inhibin
What do oestradiol and inhibin do to FSH?
It suppresses FSH secretion, via a negative feedback
Why is FSH secretion suppressed during the follicular phase?
So that only one follicle matures
What effect does oestrodiol have on LH?
It causes a positive feedback on the hypothalamus and pituitary causing LH to rise sharply, stimulating ovulation
What phase takes place during day 14-28 of the menstrual cycle?
The luteal/secretory phase
What is the corpus luteum?
The follicle from which the egg was released becomes the corpus luteum
Which hormones does the corpus luteum produce?
Oestrodiol, but relatively more progesterone
When does progesterone peak in the menstrual cycle?
Between day 21-28
What changes does progesterone have on the endometrium?
The stromal cells enlarge, the glands swell and the blood supply increases.
What happens to the corpus luteum if it is not fertilised?
It breaks down, as the hormone production stops, the endometrium breaks down
What age is normal menstruation?
Under 16 years
What age is normal menopause?
Over 45 years
How long is normal menstruation?
Less than 8 days
How much blood is normal to lose in menstruation?
Less than 80mL
What is a normal length of menstruation?
23-35 days
What is menorrhagia?
Heavy menstrual bleeding in an otherwise normal menstrual cycle
What is the clinical definition of menorrhagia?
Excessive menstrual blood loss that interferes with the woman’s physical, emotional, social and material quality of life, and which can occur alone or in combination with other symptoms
What is the objective definition of menorrhagia?
Blood loss of >80ml in an otherwise normal menstrual cycle.
What are the most common causes of menorrhagia?
- Uterine fibroids (30%)
- polyps (10%)
- dysfunctional uterine bleeding: menorrhagia in the absence of underlying pathology. This accounts for approximately half of patients
- anovulatory cycles: these are more common at the extremes of a women’s reproductive life
- uterine fibroids
- hypothyroidism
- intrauterine devices*
- pelvic inflammatory disease
- bleeding disorders, e.g. von Willebrand disease