Menopause Flashcards
What two hormones decrease during menopause?
Inhibin and AMH
Estradiol and estrone
Decreased total androgens
Which hormones increase during menopause?
FSH and LH increase during menopause
What hormone is the predominant estrogenic hormone during pregnancy?
Estrone - made mostly from peripheral conversion
What is the primary steroid secreted by the ovary during menopause?
Androstenedione
What’s the most effective treatment in menopause?
Hormone replacement therapy
What are the two FDA approved treatments for menopausal symptoms ?
HRT or paroxetine
What medication can you not give while a pt is on tamoxifen?
You can’t give SSRIs because they decrease the levels of active tamoxifen metabolite
What’s the vaginal pH in menopausal state?
> 4.5
True or false: vaginal estrogen reduces the likelihood of recurrent UTIs
True
What are the risks of estrogen only HRT?
Thromboembolic events but NOT cardiovascular or breast cancer
What are the risks of combination HRT?
Breast cancer, coronary heart disease, stroke, thromboembolic events but decreased risks of fractures and colon cancer
What are the 4 contraindications to hormone therapy?
- Known or suspected breast or endometrial cancer
- Undiagnosed abnormal genital bleeding
- Cardiovascular disease
- Active liver or gallbladder disease
What percentages do you treat someone with osteopenia?
Risk of major fracture in 10 years >20% or hip fracture >3%
What is the MOA of bisphosphonates?
Inhibits farnesyl diphosphonate synthase to reduce bone resorption of osteoclasts
What are the side effects of bisphosphonates?
GI issues and osteonecrosis of the jaw
