Menopause Flashcards
Menopause is defined as
the cessation of menses due to loss of ovarian activity, average age 51 in the US
Postmenopausal =
12+ months after final menses
Perimenopausal/ transition =
4-6 years of cycle changes and other sx before total cessation of menses
Premature menopause =
ovarian failure before the age of 40
Early menopause age =
40-45
Surgical menopause =
cessation of menses due to BSO
Menopause is a part of the normal …
aging process, is NOT a disease process
Menopause can be early in
smokers and in setting of malnutrition
Perimenopause:
Onset age =
Average length =
When does this begin?
What leads to pt’s having sx?
47
4-8 years
begins when the menstrual cycles begin to be irregular
erratic fluctuations of hormones lead to sx
Perimenopausal sx =
Vasomotor - hot flashes, night sweats, insomnia
Psych - depression, irritability, mood swings
Cognitive - concentration/ memory issues
Sexual - vaginal dryness/ dysparenia
Menstrual changes - longer/shorter cycles, irregular bleeding
other - urinary incontinence, dry itchy skin, wt gain
Physiology of Perimenopausal =
decrease synthesis of estrogens and progesterone
GnRH released at max - increasing androgens
testosterone production may continue for several more years after menopause
Types of estrogen:
Estrone (E1) = made after menopause
Estradiol (E2) = most common type of estrogen, most potent/ abundant during reproductive years
Estriol (E3) = main type of estrogen in a pregnant person’s bloodstream, prepares for childbirth
Consequences of estrogen loss
sx (early) - hot flashes, insomnia, irritability
Physical changes (intermediate) - vaginal atrophy, skin atrophy
Diseases (later) - osteoporosis, Coronary heart disease
Menopausal Menstrual changes
Luteal insufficiency - follicles become less responsive to FSH
fewer oocytes available in early follicular phase - FSH levels increase further
Corpus Luteum doesn’t function as well and progesterone secretion is diminished - result heavier menses
Changes in menstrual cycle during menopause
shortened cycles - luteal phase stays the same at 14 days but the follicular phase shortens because there are higher rates of follicular maturity
anovulation - accelerated decline in responsive follicles, bleeding episodes eventually spread out and then stop
What causes the follicular phase to shorten during menopause
Higher FSH levels cause follicles to mature faster - ovulation occurs earlier (hence the overall cycle is shortened)