Menopausal Hormone Therapy Flashcards

1
Q

Name some non-pharmacological treatment options for Vasomotor Sx

A
  • keep cool
  • avoid triggers
  • quite smoking
  • reduce weight
  • increase exercise
  • paced respiration
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2
Q

Name some triggers of vasomotor Sx

A

Can be spontaneous or triggered by…

  • embarrassment
  • change in room temp
  • stress
  • alcohol
  • caffeine
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3
Q

Vaginal dryness can be treated by…

A

Low dose vaginal estrogen

Available in creams or pessaries

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4
Q

Estrogen creams or pessaries need to be combined with progestogen. True or false?

A

False

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5
Q

Women who have had a total hysterectomy do not need which hormone?

A

Progesterone

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6
Q

What role does progesterone play?

A

Protects the uterus / provides endometrial protection

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7
Q

First line treatment for vasomotor Sx for peri/ post menopausal women?

A

Transdermal estradiol (+ progesterone for some)

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8
Q

Progestogens are added to estrogen because…

A

They reduce the risk of endometrial cancer associated with unopposed estrogen

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9
Q

Short term risks of MHT?

A

Breast tenderness, bloating, vaginal bleeding

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10
Q

Define HSDD

A

Hypoactive sexual desire disorder

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11
Q

Other can increasing libido, what other benefits does testosterone have?

A

Improves mood, energy, stamina, concentration, etc

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12
Q

Tibolone is the first choice for which patients?

A

Women with endometriosis

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13
Q

Explain tibolone

A

Progestogen with selective estrogenic activity.

Used to treat vasomotor Sx and mood and libido

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14
Q

Tibolone reduces proliferation of breast epithelial cells, true or false?

A

True. Means it does not increase mammography density

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15
Q

Which class of antidepressants can be used for vasomotor Sx in women who cannot have MHT?

A

SSRI or SNRI

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16
Q

Which 2 antidepressants are not recommended for use after breast cancer?

A

Paroxetine and fluoxetine

17
Q

Which non-hormonal drug can be used for vasomotor Sx after breast cancer?

A

Clonidine

18
Q

Name 2 gabapentinoids

A

Gabapentin

Pregablin

19
Q

Gabapentinoids are more effective for vasomotor Sx than SSRIs, but what are some of the side effects?

A

Drowsiness, dizziness, impaired balance