Mendelian Genetics Flashcards

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1
Q

Testcross

A

A way to determine if an organisms is heterozygous or homozygous for a dominant trait.

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2
Q

What is the forked-line method?

A

It is a method to do a trihybrid cross by using forked lines to “track” the inheritance.

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3
Q

Chromosomal theory of inheritance.

A

Genetic material is contained in chromosomes.

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4
Q

Locus

A

A location on a chromosome where a specific gene is located.

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5
Q

Allele

A

A variant of a given gene.

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6
Q

Product law

A

The probability of two independent events occurring simultaneously is equal to the product of the two individual probabilities.

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7
Q

How to classify two chromosomes as homologous chromosomes?

A

Same length and centromere position.
During meiosis, they pair up.
Contain identical order of gene loci.

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8
Q

Sum law

A

The probability of obtaining a single outcome, where the outcome can be achieved by two or more events, is equal to the sum of the probabilities of the individual events.

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9
Q

With probability, predictions of possible outcomes are based on what? Why?

A

Large sample sizes. A small sample size may give abnormal ratios and influence probability. These variations are due to chance.

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10
Q

What happens to chance deviation as sample size increases?

A

It diminishes.

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11
Q

Chance deviation

A

Deviations from expected results are due to chance.

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12
Q

What are Mendel’s hypothetical ratios based on?

A

Each allele is dominant or recessive.
Segregation is unimpeded.
Independent assortment takes place.
Fertilization is random.

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13
Q

What should you remember when predicting or analyzing genetic outcomes?

A

Independent assortment and random fertilization are susceptible to deviations due to chance.
Chance deviation diminishes as sample size increases.

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14
Q

MP: Unit factors in pairs.

A

Genetics characters are controlled by unit factors existing in pairs in individual organisms.

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15
Q

MP: Dominance/Recessiveness

A

When two different unit factors are present in an individual, one is dominant and one is recessive.

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16
Q

MP: Segregation

A

During the formation of gametes, paired unit factors separate randomly so that each gamete has an equal likelihood of receiving it.

17
Q

MP: Independent assortment

A

During gamete formation, segregating unit factors assort independently of each other, meaning the assortment of one does not influence another.

18
Q

Null hypothesis

A

There is no real difference between the real and measured values. Any difference is due to chance.

19
Q

What does it mean when you reject the null hypothesis?

A

The observed deviation is not due to chance alone.

20
Q

What does it mean when you fail to reject the null hypothesis?

A

The observed deviation is due to chance.

21
Q

Chi-square analysis

A

A method to determine the validity of the null hypothesis.

22
Q

What do the symbols mean in chi-square analysis?

A

o: observed values
e: expected values, from ratios
(o-e): d, deviation

23
Q

Degrees of freedom

A

It is the number of categories minus 1.

24
Q

How to determine degrees of freedom?

A

The number of categories are the number of different phenotypes possible. Minus this value by 1.

25
Q

Why is degrees of freedom important?

A

The more categories there are, the more deviation is expected due to chance.

26
Q

How to determine probability for a given chi-square and degrees of freedom?

A

Use external table. Find correct degrees of freedom row and find cell containing chi-square value.

27
Q

p<0.05

A

Observed deviation is due to chance less than 5% of the time. Reject null hypothesis.

28
Q

p>0.05

A

Observed deviation is due to chance more than 5% of the time. Fail to reject null hypothesis.

29
Q

Pedigree

A

A family tree indicating the inheritance of a specific trait.

30
Q

Consanguineous

A

Parents are closely related.

31
Q

Monozygotic twins

A

Identical twins. Same embryo.

32
Q

Dizygotic twins

A

Fraternal twins. Different embryos.

33
Q

Proband

A

The person in which the trait is first noticed.

34
Q

Characteristic of autosomal recessive traits

A

Skip generations.

35
Q

Characteristic of autosomal dominant traits

A

Present in every generation.

36
Q

Wild type

A

Trait which is most common or expected in a species.

37
Q

Transposable element

A

DNA sequence that can change its position within a genome.