Membranous nephropathy

Question 1

what is the most common cause of nephrotic syndrome in adults

Answer 1

membranous nephropathy

Question 2

which malignancies secondary to does membranous nephropathy occur

Answer 2

lung cancer

haematological cancer

bowel cancer

Question 3

what will a biopsy show in patient with membranous thickening

Answer 3

thickened basement membrane

sub-epithelial spikes

Question 4

why would you perform a urine dipstick on a patient with suspected membranous nephropathy

Answer 4

look for proteinuria

Question 5

what is the 3 initial management of membranous nephropathy

Answer 5

ACE inhibitors/ARB

Question 6

why are ACE/ARB prescribed to patients with membranous nephropathy

Answer 6

shown to reduce proteinuria and improve prognosis

Question 7

apart from ACE/ARB what other medications would you consider in high risk patients with membranous nephropathy

Answer 7

anticoagulation

Question 8

list 2 drugs that can cause membranous nephropathy

Answer 8

NSAIDs
penicillamine
GOLD

Question 9

list 2 infections that can cause membranous nephropathy

Answer 9

hepatitis B

malaria

syphillis

Question 10

what antibody is responsible for the idiopathic cause of membranous nephropathy

Answer 10

anti-phospholipid A2 antibody

Question 11

list 2 autoimmune causes of membranous nephropathy

Answer 11

SLE
thyroiditis
RA