Melanocytic and non-melanocytic lesions (pigmented lesions)

Question 1

meaning of ABCDEs

Answer 1

asymmetry
border
color
diameter
evolving

Question 2

melanocytes
neural crest cells that migrate and reside with basal epithelial cells

Answer 2

melanocytic

Question 3

what cells that migrate and reside with basal epithelial ceels

Answer 3

neural crest cells

Question 4

drugs/medication
hematoma

Answer 4

other pigments

Question 5

give 5 melanocytic lesions

Answer 5

SOCMM
- smoking-associated melanosis
- oral melanotic macule
- cafe-au-lait macules
- melanocytics nevus
- melanoma

Question 6

linked to cigarette smoking “smokers melanosis”

stimulation of melanocytes

Answer 6

smoking associated melanosis

Question 7

time and dose related

Answer 7

smoking associated melanosis

Question 8

localization for smoking associated melanosis

Answer 8

anterior labial gingiva
palate and buccal mucosa :associated with pipe

Question 9

palate and buccal mucosa associated with

Answer 9

pipe

Question 10

treatment and prognosis for smoking associated melanosis

Answer 10

smoking cessation
needs biopsy if overlappingwith other signs and questionable characteristics

Question 11

present as intraoral freckle

Answer 11

melanotic macule

Question 12

post inflammatory pigmentation
macules associated with systemic diseases

Answer 12

melanotic macule

Question 13

localization for melanotic macule

Answer 13

predominantly in any mucosal surface and vermillion of the lips

Question 14

what are systemic conditions associated with oral melanotic macules

Answer 14

peuts-jeghers syndrom
addision’s disease
laugier-hunziker syndrome
bandler syndrom

Question 15

normal numbers of melanocytes but increased melanin production

Answer 15

oral melanotic macule

Question 16

melanomas, blue nevi, amalgam tattoos
consider systemic condition

Answer 16

oral melanotic macule

Question 17

melanin-pigmented patches of SKIN that have irregular margings and a uniform brown coloration

Answer 17

cafe-au-lait macules

Question 18

neurofibromatosis for cave au lait macules

Answer 18

<0.5cm, >1.5cm, sixe or more

Question 19

albright’s syndrome
endocrene abnormalities

Answer 19

cafe au lait macules

Question 20

mole

Answer 20

melanocytic nevus

Question 21

congenital lesion composed of what cell in melanocytic nevus

Answer 21

melanocytic cells

Question 22

group of round-polygonal cells in nested pattern

Answer 22

melanocytic nevus

Question 23

round/polygonal cells in nested patter

Answer 23

melanocytic nevus

Question 24

localization of menalocytic nevus

Answer 24

palate

Question 25

no malignant potention
. must be differentieated from melanoma

Answer 25

melanocytic nevus

Question 26

subtypes of melanocytic nevus

Answer 26

junctional nevus
comound nevus
intrammucosal nervus
blues skyes

Question 27

treatment for melanocytic nevus

Answer 27

need to differentiate from melanoma
suspected nevi shoud be biopsied

Question 28

rare but < japanese population

Answer 28

melanoma

Question 29

2 biological subtypes of melanoma

Answer 29

invasive melanoma
in situ melanoma

Question 30

unusual number of melanocytes with abnormal morphology

Answer 30

melanoma histopathologic features

Question 31

stain for melanoma

Answer 31

HMB-45
S-100
MART-1

Question 32

prolonged preinvasive junctional phase

Answer 32

in situ melanoma

Question 33

poor prognosis due to delayed diagnosis and undertreatment

Answer 33

in situ melanoma

Question 34

connective tissue invation without junctional phase
poor prognosis

Answer 34

invasive melanoma

Question 35

genetic mutations

Answer 35

melanoma

Question 36

familial for melanoma

Answer 36

p16
p14
CDK4
MC1R

Question 37

sporadic for melanoma

Answer 37

BRAF
N-RAS

Question 38

chemotherapy, surgical excision

Answer 38

treatment for melanoma

Question 39

in melanoma, prognosis depends on

Answer 39

histological subtype
depth of invation
metastasis

Question 40

survival rate for melanoma

Answer 40

20% after 5 years