Melanocytes

Question 1

Where can we find melanocytes

Answer 1

oral mucosa, eye, cochlea and less con-sistently the meninges

Question 2

Vitiligo locations

Answer 2

SKin lips oral

Question 3

VKH locations

Answer 3

Skin, lips oral, eyes, meninges, auditory

Question 4

Hypothesis for vitiligo

Answer 4

Biochemical
Neural
Autoimmune (prevalent)

Question 5

Predisposed breeds for Vitiligo

Answer 5

Doperman, Rottiweiler, Collie, (reported: Belgian TErvuerens, Labrador, GS, English sheepdog, Beauceron Sheperd, iant schnauzer, miniature dachshund,Newfoundland, Bernese mountain dog)

Question 6

Reported cat breeds with vitiligo

Answer 6

Siamese, European mixed

Question 7

Reported equine with vitiligo

Answer 7

2 Gelderlands (38%), nineSpanish thoroughbreds (28%), four Arabians (13%) –common–> arabian fading syndrome, Belgians (13%) and one each (3%) of the following breeds:Oldenburg, Mecklenburg and quarter horse.

Question 8

Most common affected regions: vitiligo dog and cat and horse

Answer 8

Dog: Lips and gingiva
Cat: Nasal planum, perioccular, footpad
Horse: head, face, 1 had trunk neck and limbs without face head.
ALso “spotted leucotrichia” susp type of vitiligo in horses

Question 9

Drug induced vitiligo

Answer 9

toceranib phosphate (Palladia®) is an antineoplastic/anticancer medication used to treat mast cell tumors in dogs.)

Dexamethasone

Question 10

Treatments dog:

Answer 10

Ammoidin with solar exposure- complete response
Psoralens with UV light- almost complete response
L-phenylalanine (75% improved)
Steroids
ACTH but recured when stopped
Doxyc/niacinamide and thyroid supplemantion
spontaneous

SUM: Phototherapy/ topical steroids-> if not–> L-phenylalanine for 6months

Question 11

Treatment vitiligo horse

Answer 11

Minerals vitamines A, D, B12, E
Chelated copper (copper deficency not vitiligo

Question 12

Human genes for vitiligo

Answer 12

DR1, XBP1, NLRP1 andPTPN22