Megaloblastic Anemia

Question 1

classification of macrocytic anemia (types)

Answer 1

megaloblastic

nonmegaloblastic

Question 2

megaloblastic anemia

Answer 2

abnormal DNA maturation
delayed nuclear maturation impairs cell division
nuclear cytoplasm asynchrony

Question 3

nonmegaloblastic anemia

Answer 3

normoblastic maturations

Question 4

major causes of megaloblastic anemia

Answer 4

B12 deficiency

folic acid deficiency

Question 5

B12 deficiency is due to

Answer 5

deficiency of intrinsic factor (pernicious anemia)

Question 6

folic acid deficiency is due to

Answer 6

inadequate dietary uptake

Question 7

B12 & folic acid deficiencies lead to

Answer 7

altered DNA synthesis that affects RBC & WBC maturation
ineffective erythropoiesis
disrupted DNA synthesis

Question 8

BM megaloblasts

Answer 8

giant

abnormal appearing erythroid precursors

Question 9

megaloblastic anemia characteristics

Answer 9

onset - insidious

Question 10

megaloblastic anemia symptoms

Answer 10

lethargy, weakness, yellow orwaxy pallor
dyspeptic symptoms
glossitis with beefy red or smooth pale tongue
loss of weight or appetite
pernicious anemia

Question 11

pernicious anemia

Answer 11

atrophy of gastric parietal cells

diarrhea

Question 12

neurological disturbances in B12 deficiency

Answer 12

tingling, numbness, weakness of the extremities

abnormal gait & mental disturbances - loss of memory, depression, irritability