Mega Quiz 4 Flashcards
Elation and euphoria in bipolar can quickly change to…
…anger and hostility if behavior is impeded.
Mania is a distinct period of:
- abnormally elevated or irritable mood
- inflated self esteem/grandiosity
- decreased need for sleep
- pressured speech
- racing thoughts
- distractibility
- increased goal directed activity
- excessively risky but fun activity
A manic episode must last at least ______ days, unless psychiatrically hospitalized
7 days
Mania must NOT be:
- not mixed
- not substance induced
- not due to general medical condition
- causes marked significant impairment
Hypo mania (think “mania-lite”) involves distinct period of:
Elevated mood or irritability
Duration of hypo manic episode is atleast
4 days long
Difference between hypomania and mania
Not severe enough to cause MARKED impairment
Rates of bipolar increase after….
Puberty (when rates are as high as for adults)
Bipolar affects males and females…
Equally, but boys may show more manic mood and girls may show more depressed mood
Diseases that are comorbid with bipolar
ADHD, behavior disorders (ODD and CD), anxiety disorders, substance abuse
Medical problems that co-occur with bipolar
Cardiovascular and metabolic disorders, epilepsy, migraine headaches
What percentage of people have their first bipolar episode prior to age 19?
60%
What is the peak age of onset for bipolar?
15 and 19 years of age
Risk factors for bipolar
- Major depressive episode
- psychomotor retardation
- psychotic features
- family history of mood disorders
Early onset and course of bipolar
Chronic and resistant to treatment, with poor long term prognosis
How many youths were medicated for bipolar in 2001
93,000
Between 1994 and 2001, there was a ________ % increase in bipolar diagnoses
260%
In 2003, _______% of hospitalized youth under 12 diagnosed with bipolar
50%
Between 1994 to 2003, ______x increase in number of office visits for youth with BP
40x
Bipolar is the ______ leading disability in the world
6th
_____% of adults with bipolar end their own life
18
What percentage of people with bipolar are on 2+ meds?
85%
Lifetime medication exposure for bipolar
85% exposed to 4+ mesds
Causes of bipolar in children?
Few studies have looked at the causes of BP in kids and adolescents
Adult research regarding causes of bipolar disorder
Multiple genes (genetic predisposition does not necessarily mean a person will develop BP)
Brain imagining studies suggest mood fluctuations are related to abnormalities in areas of the brain related to emotion regulation
What happens if we don’t treat bipolar?
- mood episodes recur
- progressively more severe
- progressively more treatment resistant
Untreated bipolar disorder at increased risk for:
- substance abuse
- juvenile offending/incarceration
- suicide risk (25% show ideation)
Is bipolar curable?
No
Treatment goals for bipolar
Stabilize mood and allow for management and control of symptoms
Multimodal plan of bipolar treatment includes
:
- close monitoring of symptoms
- education of the patient and the family about the illness
- medication, usually lithium or risperdal
- psychotherapeutic interventions to address symptoms and related psychosocial impairments
Is pediatric bipolar disorder a USA phenomenon?
- clinical presentation appears fairly similar
- associated features similar
Variable rates in pediatric bipolar internationally potentially due to:
- differences in assessment and diagnostic criteria
- differences in treatment seeking
- differences in healthcare system
- different training
Asian rates of bipolar vs. USA
Lower Asian rates potentially due to:
- diet? (Fish, obesity)
- genetic risk
- differences in treatment seeking (stigma)
- different training
Treated prevalence of bipolar increased _____x in Taiwan from 1996 to 2003
8x
Bipolar rates in Singapore
- most adults with bipolar had adolescent on sent
- first episode depressed in 80%
Average rate of pediatric bipolar spectrum
2%
Is there a difference in the USA rate of bipolar disorder in kids than the world rates?
NOPE
Is USA driving the rate increase in pediatric bipolar
NO
Rank the bipolar spectrum in order of least common to most common
Severe bipolar Bipolar I Bipolar II Cyclothymia BP NOS
Bipolar NOS
Manic symptoms don’t fit into any of the previous diagnostic categories
Some ways to earn a residual diagnosis of bipolar
- manic or hypomania of insufficient duration (very rapid cycling)
- repeated hypomania with a depressive episode
- manic symptoms, but insufficient number co-occurring
What happens to bipolar NOS patients
About a 3rd recover, a 3rd remain NOS, and a third progress into more severe bipolar forms
BP NOS takes…… To remit?
LONGER
Which bipolar type has the most sick days per year?
BP NOS
BP NOS as difficult to treat
- less responsive to mood stabilizers
- no RCT for psychotherapy yet
- high rate of progression
- suicide ideation, attempts at same rate as bipolar I
Bipolar 1: 1 in ____ in Asian countries
1 in 200
BP: 2 in ___ in Europe
2 in 200
BP: 3 in ____ for New Zealand
200
BP: 3.4 in ____ for USA
200
Bipolar spectrum is ___x more likely
5x
Clear bipolar in one parent = ___x the risk
5x
Bipolar in one grandparent, aunt, uncle =
2.5x risk
“Fuzzy” bipolar or mood disorder in parents = ___ risk bipolar
2x
Using rating scales for bipolar assessment
CBCL most widely used, though similar performance on BASC, Conners, CASI
Parent report validity > teacher or youth
Can focus on externalizing score; no value added in looking at bipolar profile
Bipolar and externalizing scores
- low parent externalizing rules bipolar out
- powerful enough to reduce concerns due to family risk factors etc.
- moderate elevations (60-70) don’t change clinical impressions
- Because elevated externalizing could happen for a lot of reasons besides bipolar
GRAPES
Grandiosity Racing thoughts Activity (goal directed activity episodes) Pressured speech Elated, expansive, euphoric mood Sleep-decreased need
FIND criteria
Frequency: happening more than it should developmentally
Intensity: more severe than age appropriate
Number: excessive amount within episode
Duration: lasts much longer than developmentally appropriate
Looking for mood and energy changes in bipolar
Retro and prospective life charting
Mood and energy check ups
Process measures
Response to treatment
Outcome measures
Parent report is sensitive to treatment effects
What is the third most common illness among adolescent females
Eating disorders
Problematic eating habits and picky eating are common in…..
Early childhood (1/3 described as picky eaters)
At about age ___, girls are more anxious than boys about losing weight
9
What is the most important impact on fundamental biological processes?
Early parent child relationship
Second most significant impact on fundamental biological processes
Entering school; pressure to conform to perceptions of desirable body type
“Eating pathology”
A continuum that ranges from dieting to clinical syndromes across all ages