Meds for Different Cases Flashcards
MOA of caffeine:
- non-selective inhibition of adenosine receptors and phosphodiesterase
- results in the accumulation of cAMP and Ca2+
- causes smooth muscle relaxation and/or muscle/cardiac/CNS excitation
- B1 & B2 adrenergic stimulation 2* to catecholamine release
Uses of caffeine:
- cath lab (induce cardiac electrophysiological issues)
- supplement
- post dural puncture headache
MOA of octreotide:
- potent inhibitor of growth hormone, glucagon, and insulin
- decreases splanchnic blood flow
- inhibits release of serotonin, gastrin, vasoactive intestinal peptide, secretin, motilin, and pancreatic peptide
Uses of octreotide:
- acromegaly (reduce levels of GH)
- carcinoid tumor symptoms
- vasoactive intestinal peptide tumors (treat diarrhea)
Dose of octreotide:
initial dose of 50-500mcg IV
- may need subsequent doses during times of stress
MOA of flolan:
- direct vasodilation of pulmonary artery and systemic arterial vascular beds
- inhibits platelet aggregation
Uses for flolan:
primary pulmonary HTN
Flolan considerations (3):
1) abrupt withdrawal can lead to death
2) dedicated line w/ 0.22 micron filter
3) contraindicated in CHF
MOA of methylene blue:
inhibits NO-cGMP pathway:
- inhibits guanylate cyclase in the endothelium
- reduces NO relaxation of the vessels
Uses for methylene blue:
- hypotension
- hypoxia
- methemoglobinemia
Uses for indocyanine green:
- used in Neuro IR to determine if aneurysm/AVM repair was successful
Dose for indocyanine green:
0.5 mg/kg with injection at most proximal port given over 6-10 seconds
What to expect after indocyanine green administration:
transient drop in pulse O2 sats d/t spectroscopic contamination
Use for onyx glue
used in Neuro IR for embolization of AVM/aneurysms
Side effects of onyx glue use:
- severe pain at site of embolization
- breath and skin odor x 2-7 days
Meds in the OB hemorrhage kit:
- oxytocin (IM)
- methergine (IM)
- carboprost (IM)
- misoprostol (rectally/sublingual/PO)
- TXA (IV)
Which drug can be used to treat airway bleeding after CT-guided lunch mass ablation?
inhaled TXA (500mg) via atomizer
3 immunosuppressants given for renal transplant:
1) thymoglobulin (0.22 micron filter, central access)
2) alemtuzumab (SQ injection)
3) Basiliximab (IV)
What is the neutralizing agent for cisplatin given during HIPEC?
sodium thiosulfate
What med is often given to peds getting ear tubes?
nasal fentanyl (2mcg/kg) via atomizer
Patients with mitochondrial disorders should not receive which med?
Propofol
What is the first line treatment for laryngospasm?
succinylcholine
