Meds Flashcards
1
Q
What medications are inducers of the P450 system?
A
Rifampicin St John's Wort AntiE: Carbamezepine, Phenytoin Chronic OH- Griseofulvin Smoking Barbituates
2
Q
What medications are inhibitors of the P450 system?
A
Abx: Erythromycin, Ciprofloxacin Amiodarone Allopurinol Cimetidine, Omeprazole Na Valproate Imidazoles: Ketoconazole, Fluconazole Acute OH- intake SSRI: Fluoxetine, Sertraline
3
Q
What are the specific SE of the different antibiotics?
A
Amoxicillin= Rash w/EBV Co-Amox= Cholestasis Metronidazole= OH- reaction Ciprofloxacin= Tendonitis, lowers seizure threshold Flucloxacin= Cholestasis Doxycycline= Photosensitivity Trimethoprim= Rash, pruritus, photosensitivity, suppresses haematopoesis Erythromycin= GI, prolonged QT
4
Q
What are the SE of the anti-hypertensive groups?
A
ACEi= Cough, hyperK BB= BronchoS, fatigue, cold peripheries CCB= Headache, flushing, ankle oedema Verapamil= HF, Constipation, Brady, HypoT, Flushing Diltiazem= HypoT, Brady, Acute oedema Nif/Aml/Fle= Flushing, acute oedema Bendro= Gout, hypoN, hypoK, impaired glucose Doxazosin= Postural hypoT
5
Q
What are the SE of the diabetic med groups?
A
Met= GI, lactic acidosis Sulfonylureas= Liver dysfunction, SIADH, HypoG, ↑appetite & weight Glitazones= HypoG, Liver dysfunction, #, ↑weight, fluid retention
6
Q
How does LMWH work?
A
Activates antithrombin III
7
Q
How does unfractionated Heparin work?
A
Inhibits thrombin, factor IXa, Xa, XIa, XIIa
8
Q
What is a common SE of both LMWH & UF Heparin?
A
HyperK
Inhibit aldosterone secretion
9
Q
What is Heparin induced thrombocytopenia?
A
Day 5-10 of Tx
Immune mediated antibodies
Complexes induce platelet activation
Tx= alternative anticoagulant
10
Q
What drugs can cause pulmonary fibrosis?
A
Methotrexate
Chemo
Amiodarone
Abx: Nitrofurantoin
