Meds Flashcards

1
Q

Protein targeted therapy

A

TKIs, mTOR inhibitor, proteasome inhibitor

Rash, hand/foot, sutent-hair depigmentation
Cardio toxicity
GI- n,v,d, dec appetite

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2
Q

Angiogenesis inhibitors

A

VEGF-Bevacizumab/avastin

Immuno-modulatory-inhibit pro-inflamm cytokines
lenalidomide/revlimid
Thalidomide

Htn, thrombo embolitic events, proteinuria, bleeding, hypothyroiD

GI perf-n,v,c,fever

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3
Q

Monoclonal antibodies

A

Rituximab/Rituxan
Trastuzumab/herceptin

Infusion rxn, cardiotoxicity, myelosupp, pulm fox, rash, hand/foot

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4
Q

TKIs

A

Erlotinib/tarceva
Imatinib/gleevec
Sorafenib/nexavar
Sunitinib/sutent (hair depigment)

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5
Q

mTOR inhibitors

A

Temsirolimus/torisel
Everolimus/affinitor

(Block VEGF, PDGF)

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6
Q

Proteasome inhibitor

A

Bortezomib/velcade

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7
Q

Bendamustine/treanda

A

N,v, fatigue
Myelosupp
Infusion rxn
Tumor lysis

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8
Q

Busulfan/myleran

A

N,v,d,mucositis
Myelosupp
Hepatic tox
Adrenal insufficiency

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9
Q

Carboplatin/paraplatin

A

N, v
Myelosupp
Renal toxicity
Mild periph neurop

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10
Q

Carmustine (BCNU)

A
N, v
Myelosupp 
Hepatic
Renal
Pulm toxicities
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11
Q

Chlorambucil/leukeran

A

N, v
Hyperuricemia
Pulm tox

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12
Q

Cisplat/platinol/CDDP

A
N, v (acute and delayed)
Myelosupp 
Renal tox
Hypomag 
SIADH
Ototoxicity

Infusion rxn
Peripheral neuropathy

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13
Q

Cyclophosphamide/cytoxan/CTX

A
N,v
Myelosupp 
Bladder
Cardiac
SIADH
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14
Q

Dacarbazine/DTIC

A
N,v
Myelosupp 
Flu like sx
CNS tox
Photosensiviry
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15
Q

Ifosfamide/ifex

A
N, v, anorexia
Myelosupp 
Bladder tox
SIADH 
Neuro tox

*mesna

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16
Q

Melphalan/alleran

A

N, v, d
Mucositis
Myelosupp
Infusion rxn

17
Q

Oxali/eloxatin

A
N, v, d
Myelosupp 
Neuro tox-cold sensitivity, swallow dysesthesia
Hep tox
Allergic rxn
18
Q

Temozolomide/temodar

A
N,v
Fatigue
Myelosupp 
Headache 
Hep tox
19
Q

Thiotepa/thioplex

A

N, v, mucositis
Myelosupp
Renal tox
Bronzing of skin

20
Q

Azacitidine/vidaza

A
Nvd
Fatigue 
Myelosupp 
Hypokalemia
Renal tox
21
Q

Capecitabine/xeloda

A
N,v, d
Fatigue 
Myelosupp 
Inc bilis 
Hand foot
22
Q

cytarabine/ ARA-C

A
N v, anorexia
Mucositis 
Myelosupp 
Lethargy, confusion 
Hep, pulm tox
Conjunctivitis
23
Q

Fludarabine/fludara

A

N v d
Myelosupp
Neuro tox
Rash

24
Q

Fluorouracil/5-fu

A
N v d
Mucositis 
myelosupp 
Hand/foot
Cardio tox
Photosensitive
25
Q

Gemcitabine/gemzar

A

N v
Myelosupp
Pulm
Rash/flu like sx

26
Q

Mercaptopurine/6-mp

A
N v d
Mucositis 
Myelosupp 
Hep toxicity 
Hyperuricemia
27
Q

Methotrexate/MTX

A
Nausea
Mucositis and GI ulcerations
Myelosupp 
Renal tox 
Hep tox
Photosensitivity
28
Q

Pemetrexed/Alimta

A

N, v, d
Fatigue
Myelosupp
Rash

29
Q

Thioguanine/6-TH

A
N, v, d
Mucositis 
Myelosupp 
Renal tox
Hep tox
Rash
30
Q

Bleomycin/blenoxane

A
Pulm tox
Renal tox
Hyper pigmentation 
Skin/nail changes
Infusion rxn
31
Q

Dactinomycin/actinomycetes D

A

N, v, d
Anorexia
Mucositis myelosupp

32
Q

Mitomycin/mutamycin

A

N,v, d
Anorexia, fatigue
Mucositis
Myelosupp

Pulm tox
Renal tox

33
Q

Daunorubicin/daunomycin

A
N, v,d
Anorexia 
Mucositis 
Myelosupp 
hyperuricemia 
Cardio tox
Hyper pigmentation 
Urine may turn red
34
Q

Doxorubicin/adriamycin

A
N, v, d
Mucositis 
Anorexia 
Myelosupp 
Cardio tox 
Hand/foot 
Hyper pigmentation 
Red orange urine
35
Q

Doxorubicin liposomal /doxil

A
N, v, d
Mucositis 
myelosupp 
Cardio tox 
Hand foot 
Hyper pigmentation 
Red orange urine
Infusion rxn
36
Q

Epirubicin /ellence

A
N,v,d
Mucositis 
Myelosupp 
Cardio tox 
Skin rash
Red orange urine
37
Q

Idarubicin/idamycin

A
N,v,d
Mucositis 
Myelosupp 
Cardio tox 
Skin rash
Red urine
Elevated LFTs