Meds

Question 1

Protein targeted therapy

Answer 1

TKIs, mTOR inhibitor, proteasome inhibitor

Rash, hand/foot, sutent-hair depigmentation
Cardio toxicity
GI- n,v,d, dec appetite

Question 2

Angiogenesis inhibitors

Answer 2

VEGF-Bevacizumab/avastin

Immuno-modulatory-inhibit pro-inflamm cytokines
lenalidomide/revlimid
Thalidomide

Htn, thrombo embolitic events, proteinuria, bleeding, hypothyroiD

GI perf-n,v,c,fever

Question 3

Monoclonal antibodies

Answer 3

Rituximab/Rituxan
Trastuzumab/herceptin

Infusion rxn, cardiotoxicity, myelosupp, pulm fox, rash, hand/foot

Question 4

TKIs

Answer 4

Erlotinib/tarceva
Imatinib/gleevec
Sorafenib/nexavar
Sunitinib/sutent (hair depigment)

Question 5

mTOR inhibitors

Answer 5

Temsirolimus/torisel
Everolimus/affinitor

(Block VEGF, PDGF)

Question 6

Proteasome inhibitor

Answer 6

Bortezomib/velcade

Question 7

Bendamustine/treanda

Answer 7

N,v, fatigue
Myelosupp
Infusion rxn
Tumor lysis

Question 8

Busulfan/myleran

Answer 8

N,v,d,mucositis
Myelosupp
Hepatic tox
Adrenal insufficiency

Question 9

Carboplatin/paraplatin

Answer 9

N, v
Myelosupp
Renal toxicity
Mild periph neurop

Question 10

Carmustine (BCNU)

Answer 10

N, v
Myelosupp 
Hepatic
Renal
Pulm toxicities

Question 11

Chlorambucil/leukeran

Answer 11

N, v
Hyperuricemia
Pulm tox

Question 12

Cisplat/platinol/CDDP

Answer 12

N, v (acute and delayed)
Myelosupp 
Renal tox
Hypomag 
SIADH
Ototoxicity

Infusion rxn
Peripheral neuropathy

Question 13

Cyclophosphamide/cytoxan/CTX

Answer 13

N,v
Myelosupp 
Bladder
Cardiac
SIADH

Question 14

Dacarbazine/DTIC

Answer 14

N,v
Myelosupp 
Flu like sx
CNS tox
Photosensiviry

Question 15

Ifosfamide/ifex

Answer 15

N, v, anorexia
Myelosupp 
Bladder tox
SIADH 
Neuro tox

*mesna

Question 16

Melphalan/alleran

Answer 16

N, v, d
Mucositis
Myelosupp
Infusion rxn

Question 17

Oxali/eloxatin

Answer 17

N, v, d
Myelosupp 
Neuro tox-cold sensitivity, swallow dysesthesia
Hep tox
Allergic rxn

Question 18

Temozolomide/temodar

Answer 18

N,v
Fatigue
Myelosupp 
Headache 
Hep tox

Question 19

Thiotepa/thioplex

Answer 19

N, v, mucositis
Myelosupp
Renal tox
Bronzing of skin

Question 20

Azacitidine/vidaza

Answer 20

Nvd
Fatigue 
Myelosupp 
Hypokalemia
Renal tox

Question 21

Capecitabine/xeloda

Answer 21

N,v, d
Fatigue 
Myelosupp 
Inc bilis 
Hand foot

Question 22

cytarabine/ ARA-C

Answer 22

N v, anorexia
Mucositis 
Myelosupp 
Lethargy, confusion 
Hep, pulm tox
Conjunctivitis

Question 23

Fludarabine/fludara

Answer 23

N v d
Myelosupp
Neuro tox
Rash

Question 24

Fluorouracil/5-fu

Answer 24

N v d
Mucositis 
myelosupp 
Hand/foot
Cardio tox
Photosensitive

Question 25

Gemcitabine/gemzar

Answer 25

N v Myelosupp Pulm Rash/flu like sx

Question 26

Mercaptopurine/6-mp

Answer 26

``` N v d Mucositis Myelosupp Hep toxicity Hyperuricemia ```

Question 27

Methotrexate/MTX

Answer 27

``` Nausea Mucositis and GI ulcerations Myelosupp Renal tox Hep tox Photosensitivity ```

Question 28

Pemetrexed/Alimta

Answer 28

N, v, d Fatigue Myelosupp Rash

Question 29

Thioguanine/6-TH

Answer 29

``` N, v, d Mucositis Myelosupp Renal tox Hep tox Rash ```

Question 30

Bleomycin/blenoxane

Answer 30

``` Pulm tox Renal tox Hyper pigmentation Skin/nail changes Infusion rxn ```

Question 31

Dactinomycin/actinomycetes D

Answer 31

N, v, d Anorexia Mucositis myelosupp

Question 32

Mitomycin/mutamycin

Answer 32

N,v, d Anorexia, fatigue Mucositis Myelosupp Pulm tox Renal tox

Question 33

Daunorubicin/daunomycin

Answer 33

``` N, v,d Anorexia Mucositis Myelosupp hyperuricemia Cardio tox Hyper pigmentation Urine may turn red ```

Question 34

Doxorubicin/adriamycin

Answer 34

``` N, v, d Mucositis Anorexia Myelosupp Cardio tox Hand/foot Hyper pigmentation Red orange urine ```

Question 35

Doxorubicin liposomal /doxil

Answer 35

``` N, v, d Mucositis myelosupp Cardio tox Hand foot Hyper pigmentation Red orange urine Infusion rxn ```

Question 36

Epirubicin /ellence

Answer 36

``` N,v,d Mucositis Myelosupp Cardio tox Skin rash Red orange urine ```

Question 37

Idarubicin/idamycin

Answer 37

``` N,v,d Mucositis Myelosupp Cardio tox Skin rash Red urine Elevated LFTs ```