Meds

Question 1

2 types of bisphosphanates

Answer 1

Nitrogen containing
Non-nitrogen containing

Question 2

Nitrogen containing bisphosphanates

Answer 2

Alendronate
Risedronate
Pamidronate
Zolendronate(zoledronic acid)

“PRAZ they have nitrogen”

Question 3

Contraindications to bisphosphanates

Answer 3

Severe renal disease
Following lumbar fusion

Question 4

Mech of action for nitrogen containing bisphosphanates

Answer 4

Inhibit farnesyl pyrophosphatase synthase enzyme which inhibits GTPase formation

Question 5

Mech of action for non-nitrogen containing bisphosphanates

Answer 5

Induce osteoclasts to undergo premature death and apoptosis by forming a toxic ATP analogue

Question 6

PCN mech of action

Answer 6

Bactericidal: block cross linking via competitive inhibition of transpeptidase enzyme

Question 7

Cephalosporin mech of action

Answer 7

Bactericidal: inhibit bacterial cell wall synthesis via competitive inhibition of transpeptidase enzyme

Question 8

Vancomycin mech of action

Answer 8

Bactericidal: disrupts peptioglycan cross linking disrupting cell wall

Question 9

Beta-lactamase mech of action

Answer 9

Bactericidal: block cross linking

Question 10

Abx which disrupt protein synthesis by binding 30s subunit

Answer 10

Aminoglycosides: bactericidal
Tetracyclines:bacteriostatic

Question 11

Abx which disrupt protein synthesis by binding 50s subunit

Answer 11

Macrolides
Chloramphenicol
Linezolid

Question 12

Abx which inhibit DNA synthesis by inhibiting DNA gyrase

Answer 12

Fluoroquinolones

Question 13

Rifampin mech of action

Answer 13

Inhibits rna transcription by inhibiting rna polymerase

Question 14

Isoniazid mech of action

Answer 14

Mycolic acid synthesis inhibitor

Question 15

Bactrim mechanism of action

Answer 15

Folic acid synthesis inhibitor

Question 16

Abatacept

Answer 16

MHC - fusion protein that inhibits T cells

Question 17

Anakinra

Answer 17

IL-1

Question 18

Denosumab

Answer 18

RANKL

Question 19

Infliximab/Etanercept/adalimumab

Answer 19

TNF-alpha

Question 20

Heparin/Enoxaparin

Answer 20

AT3 activation

Question 21

Warfarin

Answer 21

Blocks Vit K epoxide reductase —> inhibits factors 2,7,9,10
Reverse with Vit K

Question 22

Fondaparinux

Answer 22

Indirect Xa inhibitor

Question 23

Aspirin

Answer 23

Irreversibly inhibits thromboxane A2

Question 24

Rixaroxaban, apixiban

Answer 24

Direct Xa inhibitor

Question 25

Dabigatran, argatroban, -rudin

Answer 25

Direct thrombin 2a inhibitor

Question 26

TXA

Answer 26

Inhibits plasminogen

Question 27

Rituximab

Answer 27

Inhibits CD20(B cells)

Question 28

Teriparatide mech of action

Answer 28

Increases serum calcium through increased bone resorption Anabolic when used intermittently PTH analog

Question 29

Baclofen mech of action

Answer 29

Activates GABA receptors which inhibits action potentials

Question 30

Clopidogrel(Plavix) Mech of Action

Answer 30

Selectively and irreversibly inhibits the binding of ADP to its platelet P2Y12 receptor, thereby inhibiting platelet aggregation