Medicine Qbank Flashcards
2 options for chest pain at rest and no ST-elevation on EKG
- Unstable angina 2. NSTEMI (see elevated biomarkers)
Acute pericarditis is diagnosed by
2 of the 3: 1. pleuritic chest pain 2. friction rub 3. diffuse concordant ST-segment elevation on EKG.
EKG findings of acute pericarditis?
(non-diagnostic in 50% of pts): diffuse ST-seg elevation
What is the preferred tx for STEMI?
Percutaneous angioplasty and stent (lower 30-day mortality compared to thrombolytic)
2 ways to get relief from angina pectoralis pain
- rest 2. nitroglycerin
Pt with R-side STEMI has low bp. What is the first step in management?
Fluid bolus to improve filling (diastolic problem). If fails, try inotropic support like dobutamine (not first since can extend infarct). Don’t give B blocker as bradycard worsesns HD instability. Don’t give nitroglycerin as venodilation impairs RV filling
What is empiric therapy for GERD?
PPI
MSSA peritoneal infx abx?
Clinda
What is appropriate therapeutic INR?
Normal range for pts not on any meds is 0.8 - 1.2
For pts w/ idiopathic VTE or afib, 2 - 3.
For pts w/ prosthetic heart valves, 2.5 - 3.5.
Abx for cat scratch disease?
PO azithromycin for Bartonella henselae
What is bone/joint related abnormality 2/2 steroid use?
Osteonecrosis of right femoral head = osteochondritis dessicans
First degree heart block types
AV block w/ normal QRS: oft due to delayed AV nodal conduction, no further eval needed
# w/ prolonged QRS: likely conduction delay bleow AV node –> need electrophys test as may unpredictably progress to advanced 2nd degree or complete heart block
What is pathogenesis of renal vein thrombosis as a complication of nephrotic syndrome?
Lose antithrombin (which is activated by heparin) III in urine –> incr risk of venous/arterial thrombosis. Sx: sudden onset abd pain, fever, hematuria. Most common w/ membranous glomerulonephritis
“Tea and toast”
Folic acid
What are signs/sx of eosinophilic pneumonia?
Gradual asthma-like sx, hear diffuse wheezes, fine inspiratory crackles (bronchial/interstiial involvement)
Dx of aspirin exacerbated respiratory disease (AERD) w/ (3)
- asthma 2. chronic rhinosinusitis w/ nasal polyposis 3. bronchospasm or nasal congestion after asa/NSAIDS
Shunt causes what sort of acid-base disorder?
Respiratory acidosis
V/Q mismatch causes what sort of acid-base disorder?
Due to decrease in PaCO2, compensatory tachypnea –> resp alk
What are 4 causes of V/Q mismatch?
Pulm emb, atelectasis, pleural effusion, pulm edema
First line tx for prolactinoma?
Dopaminergic agents - cabergoline
Cutoff for pituitary tumor microadenoma?
Treatment of hyperkalemia w/ EKG changes?
- administer IV Ca gluconate to stabilize cardiac membrane
- Lower serum K by driving intracellularly - insulin and glucose, Na bicarb, beta2 (albuterol) - “Get In Bye Bye”
- Eliminate excess K from body via kayexalate
What is the mech of nitroglycerine in pain relief of angina?
Dilation of veins
Which risk factor has strongest assoc w/ aortic dissection?
Htn
Where is the most common site of htn hemorrhage of brain?
Putamen. Internal capsule usu involved –> contralat dense hemiparesis
Rx for Nocardia?
TMP-SMX
How do you diagnose leprosy?
Skin biopsy –> acid-fast bacilli
Asian paitent, hypopigmented patch of skin –> suspect
Leprosy
What are the 3 etiologies of acute urinary retention in the elderly?
- Obstruction (BPH or carcinoma) 2. Neurogenic bladder 3. Detrusor muscle underactivity
What are 4 etiologies of overflow incontinence from acontractile bladder?
- Diabetic neuropathy, 2. MS, 3. anesthetic drugs, 4. drugs
What’s suspected w/ large amt of blood on UA but few RBCs?
Rhabdomyolysis (which –> acute renal failure)
What are classic sx of disk prolapse?
Unilateral radicular pain in dermatomal distribution
What are sx of cauda equina syndrome?
Saddle anesthesia, lose of sphincter tone, bladder atony w/ overflow incontinence, bilat sciatica
Sx detrusor instability?
Incontiencne preceded by sudden urinary urgency
Sx hypertonic bladder?
Constant urine dribbling 2/2 unremitting contraction of bladder
Imaging study of choice for suspicion of pancreatic ca?
If jaundice - start w/ u/s. If no jaundice but epigastric pain and weight loss - start with CT.
Varying amplitude of QRS complexes is called what?
Electrical alternans: pathognomonic for pericardial effusion
What is procainamide used for?
Class Ia, used to treat SV and V arrhythmias, particularly Wolff-Parkinson-White
How is SLE arthritis diff from RA?
Both affect MCP and PIP, but SLE arthritis is non-deformig
When is parathyroidectomy recommended for asymptomatic patients with primary hyperparathyroidism?
- Serum calcium level >= 1 mg/dL above upper limit of normal 2. Age
How do you distinguish btw primary hyperpara vs. familial hypocalciuric hypercalcemia?
With PH, 24 hr urinary ca >250 mg. With familial,
Varicoceles that don’t empty when pt is recurrent are due to
Tumor obstruction of gonadal vein, increased suspicion for mass obstruction to venous flow
New-onset thrombocytopenia, arterial thrombosis (cold extremity), and/or >50% drop in platelet count 2/2 to which drug for DVT?
Heparin –> HIT. Type 1: Due to nonimmune direct effect of heparin on platelet acctivation, happens w/in 2 days. Type 2: Immune-mediated
What is a factorial study design?
Involes 2 or more experimental interventions, ea w/ 2 or more variables studied independently
Can steroid use increase Hct?
Yes! So don’t think epo use if a pt has gynecomastia
Typical sx of digoxin tox?
N/v, decr appetite, confusion, weakness, arrythmias. Can be triggered by volume depletion, renal injury.
# Get blood drug level, EKG, and INR
What is a TACE procedure?
Limit blood supply to tumors
What is rifaximin used for?
Based on rifamycin, poor GI absorption. Used for traveler’s diarrhea, hepatic encephalopathy
What are the presenting signs/sx of DKA?
N/V, thirst, increased urination, abd pain. Labs show anion gap metabolic acidosis
Diagnosis of DK is made by
- Blood glucose >250, 2. pH
What is pseudodementia/reversible cognitive impairment?
Severe depression presenting w/ features similar to dementia. For most, return to baseline w/ rx of dementia
Why are patients w/ RA at increased risk for osteoporosis?
Incr proinflammatory cytokines, glucocorticoids, and lack of phys activity –> local/generalized loss of bone
What are the 2 dz associations of steitis fibrosa cystica?
aka von recklinhausen disease. Parathryoid carcinoma, hyperparathyroidism
Pts w/ GCA (giant cell arteritis) have what phys exam?
Scalp tenderness, decr temporal artery pulse
What is a complication of GCA that warrants monitoring?
Aortic aneurysms - need serial cxr’s
What are the criteria for drainage of a pseudocyst?
- Persists >6wk 2. > 5cm diameter 3. Secondary infx
What is within a pseudocyst?
Enzyme-rich fluid, tissue, debris
Arortic artery dissection can extend into
- Carotid arteries (stroke), 2. renal arteries (AKI), 3. aortic valve (aortic regurge), and/or 4. pericardium (tamponade)
Firm, hyperpigmented nodule that has central dimpling when area is pinched
Dermatofibroma
What is the mech of coagulation in antiphospholipid sydnrome?
Unknown
Which lab value is changed in antiphospholipid syndrome?
Prolonged PTT. 20-40% pts may have thrombocytopenia
What dz defined by inflammation of one eye after penetrating injury to the other?
Sympathetic ophthalmia = spared eye injury. Caused by recognition/uncovering of “hidden” antigens
Side effect of hydroxychloroquine?
GI disress, visual disturbance, in G6PD pts, hemolysis
Side effect of mtx?
Macrocytic anemia (everything is bigger in mTX) Nausea, stomatitis, rash, hepatotoxicity, interst lung dz, alopecia, fever.
What are the pulses associated with aortic regurge?
Bounding pulse
What are the pulses assoc with aortic steosis?
Pulsus parvus = decreased pulse amplitude and tardus = delayed pulse upstroke
If a test result is negative, the prob of having dz is
1 - negative predictive value
Labs of CML?
Leukocytosis w/ left shift (myelomonocytes, neutrophils, etc), basophilia, marked splenomegaly
What STD swcreening for all pts (even asymptomatic)?
HIV
Which org causes acute retinal necrosis syndrome in HIV+?
HSV & VZV - can cause pain, keratitis, uveitis, necrosis
Which org causes benign retinitis in HIV+?
CMV
What are ECG findings of afib with RVR?
Narrow-complex tachy, irregularly irregular, no organized P waves
What is lidocaine used for in cardiology?
Antiarrhythmic for ventricular arrythmia
What is paroxysmal supraventricular tachycardia?
Sudden-onset, regular, narrow-complex tachycardia. Use adnosine or carotid sinus massage
Cerebral lesions cause gaze deviation_
toward side of the lesion
Pontine and thalamic lesions cause gaze deviation_
Away from side of the lesion
Sx of ruptured berry aneurysm?
H/a, impaired arousal, seizure, meningismus
Describe lab values of SIADH
Euvolemic hyponatremia, decr serum osm, incr urine osm
Pleural effusion on R suggests
Hepatoic hydrothorax 2/2 cirrhosis
Moderately elevated AST, ALT, alk phos suggestive of
- infiltratitive (ie. cancer) 2. cholestatic dz
What are blood test signs of cirrhosis?
Thrombocytopenia, coagulopathy
What can cause refractory hypokalemia despite repletion?
Hypomag
What is the rx for mild hypovolemic hypernatremia?
5% dextrose in 0.45% NS
What is the rx for severe hypovolemic hypernatremia?
9% NS (will still be hypotonic in comparison)
What is the rx for hypervolemic hypernatremia?
5% dextrose in water
What is the goal rate of sodium correction?
no more than 1 mEq/L/h
Which 3 labs are elevated in rhabdo?
CK, myoglobin, K+
What are 2 risk factors for rhabdo?
- immobilization (direct msucle damage) 2. cocaine vasoconstricts –> ischemia, seizure, agitation, hyperpyrexia, myocyte toxicity –> muscle breakdown
Are cholesterol stones visible on xr?
No, they’re radiolucent.
What is pathophysiology of pernicious anemia?
Autoimmune disorder. Anti-intrinsic factor antibodies
True cirrhosis is characterized by the presence of
regenerative nodules
What are the 3 stages to alcoholic liver dz?
- Fatty liver 2. Alcoholic hepatitis (Mallory bodies, neutrophil infiltration, liver cell necrosis, perivenular distribution of inflammation). 3. Cirrhosis
What is vitamin def seen with serotonin syndrome?
Niacin (due to decr tryptophan used to make serotonin instead)
How can AKI cause metabolic acidosis?
Non-anion gap: 1. impaired H+ secretion 2. ammonia generation 3. bicarb reabsorption. # anion gap: retention of uremic toxins –> encephalopathy
How does GI bleed cause elevated BUN?
Metabolism of blood proteins –> urea. Pts have NORMAL anion gap compared to AKI –> uremic toxins
What are the 2 interventions tha decrease mortality in COPD?
Home O2, smoking cessation
Odds ratio from case-control studies is a good approximation of
Relative risk if the outcome is uncommon (rare disease assumption)
Young obese female with a headache
Suspect benign intracranial hypertention w/ nl MRI and CSF. Aka pseudotumor cerebri. Caused by impaired absorption of CSF
What are neuro signs for pseudotumor cerebri?
Papilledemia, visual field defects, sometimes CN VI palsy
What is the most significant complication of pseudotumor cerebri?
Blindness
Pts with new thrombocytopenia should get what lab test?
HIV, HCV
What are clinical findings in chronic HIV infx?
Oral candida, Peripheral neuropathy, FUO, LAD, etc
Sx of delayed sleep phase syndrome?
Pts describe selves as night owls, chronic problems sleeping at socially accepted time, normal when allowed to set own schedule
Pt w/ stone. Urinalysis shows hexagonal crystals. Urinary cyanide nitroprusside is +. Stones are hard and radioopaque. What is cause?
Cystinuria: abn amino acid transport in renal tubular and intestinal epithelium
Ddx for fever, night sweats, productive cough, weight loss
- chronic infx 2. malignancy 3. rheum
Fever, weight loss, lytic bone lesions, well-circumscribed, verrucous, crusted skin lesions
Blasto
Eyes: microaneurysms and hemorrhages, macular edema
DM retinopathy
Eyes: multiple sores in macular region or new blood vessels that leak/bleed/scar the retina
Macular degeneration
What is a lab abnormality caused by hypothyroidism?
Hyperlipidemia - met imbalance
# Hyponatremia - decreased free water clearance
# elevated CK and AST and ALT
Complicated pleural effusion defined as
pH
HHS typically presents with (3)
- hyperosm 2. vol depletion 3. severe hypoglycemia w/o ketone
How does dehydration cause HHS?
Decr GFR (decr glucose excretion) –> activate counter-reg hormones (incr glucose production, impair utilization) –> hyperglycemia (pts have enough insulin to prevent ketosis)
Dx of HHS
Serum glucose >600, plasma osm >320, absent ketons
What is Zollinger-Ellison?
Gastrin-secreting tumor of pancreas/duodenum. Acid hypersecretion –> ulcers in distal duodenum, jejunum
What is the most common cause of hc-associated endocard?
Staph
Bug of endocard after nosocomial UTI?
Enterococci
What is #1 cause of death in endocarditits?
CHF
What are the 2 preferred therapies for hep B?
(Check hep B viral load!) 1. Entecavir, 2. Tenofovir
Which patients are less likely to respond to hep B therapy?
Pts w/ normal ALT
When do you use interferon for hep B?
Younger pts w/ compensated liver dz, short-term
Rhizopus found where in DM pts?
Paranasal sinuses, extend to orbit and brain
Granulations in L ear canal, facial asymmetry, downward deviating side of mouth concerning for
Malignant otitis externa –> osteo of skull, CN damage
Unilateral acoustic neuroma after 40 y.o. assoc w/
NOTHING
Daily oral theophylline used as
Alt adjunctive for any form of asthma except mild intermittent
Which meds may cause NMS?
Typical and atypical antipsych
All pts complaining of wheezing and other complaints of asthma should be screened for
GERD, as 75% of asthma pts also have GERD
Think GERD-induced asthma if
Sx worse after meals, exercise, laying down
Antidote for CN poisoning?
Hydroxocobalamin or sodium thiosulfate
Which antibodies (2) for celiac?
Anti-endomysial and anti-tissue transglutaminase
Long-term NSAIDS can cause these 2 conditions
- CKD 2/2 tubulointerstitial nephritis 2. hematuria 2/2 papillary necrosis
Difference in murmurs of papillary muscle rupture vs. ventricular septal rupture
Both have pansystolic murmur. Papillary rupture - heard loudest at apex w/ radiation to axilla (mitral regurge). Ventricular septal rupture - best heard at L sternal border, oft accomp thrill
Ddx of peripheral edema
CHF
# Liver dz
# Renal dz
# Venous insufficiency
# Side effect of dihydropyridine CCB (amlodipine)
Bloody diarrhea in HIV pt?
CMV colitis - see ulcers
Cutoff size for lung nodule just to warrant obs
3cm or less
What are the most common causes of AL and AA amyloid?
AL => MM. AA => RA.
Lumbar spinal stenosis is painful with
walking and lumbar extension
Lumbar disk herniation is painful with
siting and lumbar flexion
Causes of digital clubbing
Malignancy, CF, R-to-L cardiac shunts
Change in Ca2+ 2/2 alkalosis?
Incr in Ca2+ bound to albumin
Cervical LN > 2.0 cm associated with
greater likelihood of malignancy or granulomatous dz
Otosclerosis - hearing loss due to bony overgrowth of stapes - charcteristic
Low-freq hearing loss, in middle-aged individuals
Murmur worsens in pts with hypertrophic cardiomyopathy w/ maneuvers that
decrease preload –> smaller LV volume –> more obstruction
What are first line agents for hypertrophic cardiomyopathy?
BB or CCB to slow the heart and prolong diastole
MOA of nitrates?
“lmNOP” - Nitrates lOse Preload - primary venodilator
MOA of digoxin?
Positive inotrope
Upper vs. lower throacic spinal cord?
Dermatomes: upper = nipples, lower = umbilicus
Does hyper or hypocalcium cause stones?
Both!! Decr dietary ca –> Incr oxalate absorption in gut –> incr excretion in urine that binds to urinary Ca
Subacromial bursitis is seen with and presents as
Result of repetitive overhead motion of arm, pain w/ internal rotation and forward flexion of shoulder
What are the criteria for Behcet’s syndrome?
Recurrent oral ulcers and 2 of the following: recurr genital ulcers, eye lesions (uveitis), retinal vascularization, skin lesions, +pathergy test
Pts w/ CKD have hypocalcemia
Because unable to form 1,25 vit D –> decr intestinal absorption of Ca
Anterior uveitis vs. keratitis vs. episcleritis
Anterior uveitis: conjuctival inflammation, but cornea usu spared
# Episcleritis: common cause of red eye that’s localized, patchy, mild pain and d/c. Doesn’t affect vision or cornea
Conjunctivitis = no cornea. Keratitis = yes cornea