Medicine management Flashcards
HTN
Diabetic anyone: ACEi
- <55ACEi/ARB, >55/black CCB
- ACEi/ARB + CCB (Blacks prefer ARB)
- Thiazide
- more thiazide/spironolactone
HF
- ACEi/BB
- ARB/Furosemide/Spironolactone/Hydralazine + nitrate (black)
- Digoxin
Angina
- Lifestyle: smoking, weight/exercise
- Aspirin, Clopidogrel, Statin, ACEi, BB, CCB/ARB
- Symptoms: GTN spray - Surgery: PCI/CABG
Asthma
- SABA -> ICS appears to be 1st line now, SABA with exacerbations
- ICS
- LRTA antagonist (montelukast)
- LABA (instead of SABA)
- OCS (pred) (CI in paeds)
- Hospital MART (maintanance and reliever therapy)
COPD
SAMA/LAMAntagonists, ICS, theophylline + O2 if bad LAMA used 1st line maintenance SABA used 1st line rescue therapy Adjuncts: mucolytic Diet: high calories
UTI
- Nitrofurantoin/trimethoprim
2. Amoxicillin/cefalexin
Anti-HER2 breast cancer
Trastuzumab
Premeno breast cancer
Oophrectomy + tamoxifen
Postmeno breast cancer
Aromatase inhibitor Anastrozole
Diabetes
- Diet/exercise
- Metformin
- Sulfonylurea (gliclazide)
- Thiazolidinedione/Incretin/SGLT-2 inhibitor/GLP-1 agonist
- Insulin therapy -> can increase dose
Schizophrenia
- Atypical (aripiprazole)
- Add a/typical
- Clozapine
Generalised Anxiety
- SSRI
2. TCA/antipsychotic/benzo/pregabalin
Depression
- SSRI
- SNRI
- TCA/MAOI
C diff
- Vancomycin or metronidazole
- Both
- Faecal donor
RA
- DMARD + prednisolone + NSAID + PPI
Non-pregnant: methotrexate/leflunomide
Pregnant: sulfasalazine/hydroxychloroquine - Biologics
H. pylori
Omeprazole, Amoxicillin/metronidazole, clarithromycin
MS
Acute: methylprednisolone
Ongoing: complicated
GORD
- Lifestyle: weight, alcohol, smoking
- Antacids
- PPI/H2-antagonist
OA
- Lifestyle: weight, smoking, exercise/physio
- NSAIDS + steroids + PPI
- Arthroplasty
Herpes simplex/zoster
Acyclovir
Dementia
- AChEi: donepezil/galantamine/rivastigmine
2. Aspartate/NMDA inhibitor: memantine
Gonorrhoea
100mg IM Ceftriaxone
Chlamydia
Doxycycline BD 7d
Pregnant: Azithromycin
NGU
- Doxycycline 7d, Azithromycin 2d
3. Moxifloxacin 10d
HPV6/11/16/18
Gardasil
PID
- Ceftriaxone + Doxycycline + Metronidazole
Pubic lice
Lyclear permethrin cream + malathion
Delirium
- Underlying disease
- Haloperidol + olanzapine/risperidone
- Benzodiazepine (any withdrawal)
Ischaemic stroke
<4.5h: thrombolytic alteplase + thrombectomy + aspirin 300mg for 2W/clopidogrel + atorvastatin after 48h
>4.5h/thrombolysis contraindicated: Aspirin 300mg + atorvastatin after 48h
AF: warfarin
Secondary prevention:
1. Clopidogrel, atorvastatin, HTN treatment
AF: anticoagulant
Epileptic fit (including monitoring)
Monitoring: ECG + BP
<5mins: 1st aid
>5mins: Rectal diazepam, IV lorazepam, Buccal midazolam
Status epilepticus
20-40mins: Alert anaesthetist + Levetiracetam/s valproate/Phenytoin/fosphenytoin
40-60mins: propofol/midazolam/thiopental
Polymorphonuclear meningitis
including contact prophylaxis
1200mg penicillin/Ig cefotaxime + dexamethosone
Contact: rifampicin
AF (stable, unstable, prophylaxis)
Stable: - Rate 1. BB/CCB (verapamil) 2. Digoxin 3. Digoxin + BB + CCB (diltiazem) -Rhythm: defibrillation HC: amiodarone No HC: sotalol, flecainide, propafenone Unstable: 1. Defib + heparin 2. Defib + amiodarone Prophylaxis: warfarin + dab/riv/apix
Osteoporosis (including vits)
Vitamins (calcium + vit D
- Alendronate
- Denosumab
- Oestrogens/testosterone
- PTH injection?
Ankylosing spondylitis/psoriatic arthritis
- Morning exercise/physio
- NSAIDS + PPI
- Methotrexate
- TNF-alpha
GCA
Prednisolone
- Fugax: IV pred
ICP
- Mannitol
- Sedation (propofol + morphine)
- Cut skull
Cerebral oedema
dexamethosone
Migraines (including preventon)
Paracetamol/NSAIDS/triptans/High dose aspirin/Metocloperamide (antiemetic)
Prevention: topiramate, propranolol, amitryptiline, botox
Cluster
O2 + topiramate/triptan
Trigeminal neuralgia
Carbemazepine
TB chronic meningitis
Pred, rifampicin, isoniazid, pyrazinamide
SAH
nimodipine
Myasthenia gravis
Neostigmine, Pred+ azathioprine, ventilation
Motor neuron disease
Riluzole
Parkinson’s
Co-careldopa (carbidopa, levodopa)
HIV
2NRTIs + 1 other
PEPSE (including days)
Tenovir + Raltegravir 28d
Postural hypotension
Fludrocortisone
Midodrine
Bulaemia
Fluoxetine
Anorexia
Fluoxetine + atypical?
Delirium tremens
Chlordiazepoxide (long acting benzo) + B1 injection
Alcohol relapse prevention
Acamprosate
Disulfiram
Naltrexone
Nasal polyps
- Fluticasone/mometasone spray
2. Surgery
Benzo OD
Flumazenil
Essential tremor
Propranolol/little alcohol
Bipolar disorder 2
Carbamazepine + lamotrigine
Otitis externa
Vinegar + flumetasone/clioquinol/ + suction + NSAIDS/paracetamol
Otitis media (including AB treatment criteria)
paracetamol +NSAIDS +/- amoxicillin
- Amox if really bad or bilateral, or <2Y/O
Cholesteatoma (surgery, no drugs)
Mastoid sac debris removal
Tonsillitis (including course length)
Salt water + pred + 10d ABs
- Amoxicillin/methylpenicillin + pred
- Erythromycin + pred
Wet macular degeneration
Anti-VEGF
Gonococcal conjunctivitis
Penicillin
Non-gonococcal conjunctivitis
Chloramphenicol
Chlamydial conjunctivitis
erythromycin
Viral conjunctivitis
Corneal involvement: steroid eyedrops
Herpes simplex conjunctivitis
Acyclovir
Allergic conjunctivitis
Olopatadine
Darycocystitis
Cefalexin
Blepharitis
Chloramphenicol
Trachoma
Azithromycin
Open angle glaucoma
timolol, latanoprost, acetazolamide
Closed angle glaucoma
pilocarpine + acetazolamide
CRAO
aspirin + acetazolamide
Amaurosis fugax
Aspirin
CRVO
Glaucoma treatment
Hyperprolactinaemia
Dopamine agonist/surgery
Acromegaly
somatostatin/dopamine agonist/surgery
Pruritus eczema
Antihistamine
Eczema
Emolient: creams -> ointments
Corticosteroid: hydrocortisone -> eumovate -> betnovate -> dermovate
Anaemia
- Diet/underlying cause
- Ferrous sulphate
- Ferrous GLuconate
Pernicious anaemia: B12
Acne vulgaris
General: anticomedonal + antikeratolytic + antibiotic
Mild: Adapaline, Benzoyl peroxide, topical erythromycin
Moderate: COC (females) + oral doxycycline/lymecycline
Severe: Isotretinoin (anticomedonal)
Cellulitis (including patient position)
Flucloxacillin/benzylpenicillin + leg raise
Pen allergy: clarithromycin
Impetigo (including MRSA)
- Fusicid cream 3x 7d
- Oral flucloxicillin/erythromycin/clarithromycin
MRSA: mupirocin
Yeast infection
Miconazole
Non-yeast fungal infection (including infection location determining route)
Terbinafine
- Skin: topical
- Widespread/nails: oral
Asthma exacerbation
Status asthmaticus
O2 + salbutamol (SABA) + prednisolone (IV)
- ABs if infection signs
- MgSO4 life-threatening
“ and ipratroprium bromide (SAMA)
COPD exacerbation (including ABs regime + prophylaxis)
O2 + SAMA/SABA + pred + ABs + ventilation + LMWH
Theophylline: if SAMA fails
ABS:
1. Amoxicillin + doxycycline 5d -> doxycycline 4d more
2. Clarithromycin 5d
Doxapram: if no ventilator
Prophylaxis: pneumococcal vaccine + flu jab
Ulcerative colitis/Crohn’s
UC flare suppression: Crohn's Budesonide instead of mesalazine 1. Mesalazine 2. Corticosteroid 3. Azathioprine 4. Infliximab 5. Vedolizumab 6. Colectomy UC maintenance: mesalazine Crohn's maintenance: methotrexate/azathioprine
Hep B (serious)
Tenovir
DVT (including prophylaxis + cancer patients)
Acute:
1. LMWH/UFH (5d) + NOAC (rivaroxaban) (6M)
- Cancer: LMWH/UFH (3M)
Prophylaxis: LMWH/warfarin
PE
DVT + O2 + morphine DVT: Acute: 1. LMWH/UFH (5d) + NOAC (rivaroxaban) (6M) - Cancer: LMWH/UFH (3M) Prophylaxis: LMWH/warfarin - Pregnant prophylaxis: LMWH only Haemodynamic instability: thrombolytic alteplase