Medicine - Haematology Flashcards
What tests should you order when querying IDA in a sick vs healthy patient?
No illness: Ferritin
Illness: TIBC, TF, iron
Why? Ferritin is an acute phase protein
What markers will be raised in iron deficiency anaemia?
LDH, haptoglobins, uBR
Differentiate the class of immunoglobulin associated with warm vs cold AIHA?
Warm: IgG
Cold: IgM
How is warm AIHA managed?
Steroids, splenectomy
Recall some causes of warm AIHA
Lymphoma
CLL
Drug allergy
SLE
Recall some causes of cold AIHA
Myclopasma pneumoniae
EBV
CMV
What abnormality would be seen on blood film in warm AIHA?
Spherocytes
What test is used to identify paroxysmal nocturnal haemoglobinuria?
Ham’s test
If warm AIHA and hereditory spherocytosis both have spherocytes, what test can be used to differentiate them?
Coomb’s/DAT test
Positive in AIHA
Neg in HS
Recall 3 possible causes of MAHA
HUS
TTP
Adenocarcinoma
Recall 3 electrolyte abnormalities seen in tumour lysis syndrome
Hyperkalaemia
Hyperphosphataemia
Hypocalcaemia
How should tumour lysis syndrome be managed?
Allopurinol
IV if high risk
PO if low risk
What Hb level indicates packed RBC transfusion?
No ACS: <70g/L
ACS: <80g/L
Recall 4 contraindications for platelet transfusion
Chronic BM failure
Heparin-induced thrombocytopaenia
ITP
TTP
Which inherited thrombophilia increases the relative risk of DVT the most?
Antithrombin III deficiency